ChemicalBook > CAS DataBase List > IKK 16

IKK 16

Product Name: IKK 16
CAS No.: 873225-46-8
Chemical Name: IKK 16
Synonyms: CS-1847;IKK Inhibitor;IKK 16 USP/EP/BP;IKK-16(free base);IKK Inhibitor VII;IKK 16, 10 mM in DMSO;IKK16;IKK-16;IKK INHIBITOR VII;Abmole M2768-1mg IKK-16 873225-46-8;1-[4-[(4-Benzo[b]thien-2-yl-2-pyrimidinyl)amino]benzoyl]-4-(1-pyrrolidinyl)piperidine;Leucine-rich repeat kinase 2,Inhibitor,IKK 16,LRRK2,inhibit,IKK,I kappa B kinase,IκB kinase
CBNumber: CB92666638
Molecular Formula: C28H29N5OS
Formula Weight: 483.63
MOL File: 873225-46-8.mol

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IKK 16 Property

storage temp.: Store at -20°C
solubility: ≥23.05 mg/mL in DMSO; ≥11.3 mg/mL in EtOH with ultrasonic; insoluble in H2O
form: solid
color: White to yellow
InChIKey: BWZJBXAPRCVCKQ-UHFFFAOYSA-N
SMILES: C(C1=CC=C(NC2=NC=CC(C3SC4=CC=CC=C4C=3)=N2)C=C1)(N1CCC(N2CCCC2)CC1)=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1138
Product name: IKK-16 dihydrochloride
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $153
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1138
Product name: IKK-16 dihydrochloride
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $611
Updated: 2025/07/31

TRC

Product number: B207020
Product name: [4-[(4-Benzo[b]thien-2-yl-2-pyrimidinyl)amino]phenyl][4-(1-pyrrolidinyl)-1-piperidinyl]-methanone
Packaging: 10mg
Price: $185
Updated: 2021/12/16

ChemScene

Product number: CS-1282
Product name: IKK16
Purity: 99.09%
Packaging: 10mg
Price: $174
Updated: 2021/12/16

ApexBio Technology

Product number: B1586
Product name: IKK-16(IKKInhibitorVII)
Packaging: 10mg
Price: $126
Updated: 2021/12/16

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IKK 16 Chemical Properties,Usage,Production

Uses

IKK-16 is a potential novel IκB kinase 2 (IKK2) inhibitor used in the treatment of various immune/inflammatory disorders.

Definition

ChEBI: [4-[[4-(1-benzothiophen-2-yl)-2-pyrimidinyl]amino]phenyl]-[4-(1-pyrrolidinyl)-1-piperidinyl]methanone is a N-acylpiperidine and a member of benzamides.

Biological Activity

ikk-16 (ikk inhibitor vii) is a novel inhibitor of iκb kinase (ikk) with the ic50 values of 0.04μm, 0.2μm and 0.07μm for ikk2, ikk1 and ikk complex, respectively [1].ikk-16 (ikk inhibitor vii) is a 2-benzamido-pyrimidines and selective inhibitor of iκb kinase (ikk). ikk-16 has been reported to effectively inhibit tnfα release into plasma upon lps-challenge in the rat. in addition, ikk-16 has been found to be active at thioglycollate-induced peritonitis model in the mouse. furthermore, ikk-16 has revealed to be an orally bio-available in rats and mice, and have significant in vivo activity in an acute model of cytokine release [1].

in vivo

IKK 16 also demonstrates significant in vivo activity in an acute model of cytokine release. Both routes of administration of IKK 16 (30 mg/kg, sc) or orally (30 mg/kg, p.o) at the indicated dose results in a significant inhibition of 86% (sc) and 75% (p.o.). IKK 16(10 mg/kg, sc) is also active in the thioglycollate-induced peritonitis model in the mouse. The maximal inhibition of neutrophil extravasation in this model is about 50%^[1]. Treatment of septic mice with IKK 16 (1 mg/kg body weight i.v.) results in a significantly increased degree of phosphorylation (P<0.05) of serine residues on Akt and eNOS in the liver^[3].

target

IKK-2

IC 50

IKK2: 40 nM (IC₅₀); IKK1: 200 nM (IC₅₀); IKK: 70 nM (IC₅₀); LRRK2: 50 nM (IC₅₀)

References

[1] waelchli r1, bollbuck b, bruns c, buhl t, eder j, feifel r, hersperger r, janser p, revesz l, zerwes hg, schlapbach a.design and preparation of 2-benzamido-pyrimidines as inhibitors of ikk. bioorg med chem lett. 2006 jan 1;16(1):108-12. epub 2005 oct 19.

IKK 16 Preparation Products And Raw materials

Raw materials

Preparation Products

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873225-46-8, IKK 16Related Search:

NA INK 128 (MLN0128) QNZ (EVP4593) MK-2206 2HCl TPCA-1 Trametinib IKK Inhibitor III, BMS-345541

IKK Inhibitor

[4-[(4-Benzo[b]thien-2-yl-2-pyriMidinyl)aMino]phenyl][4-(1-pyrrolidinyl)-1-piperidinyl]-Methanone

IKK Inhibitor VII

Methanone, [4-[(4-benzo[b]thien-2-yl-2-pyrimidinyl)amino]phenyl][4-(1-pyrrolidinyl)-1-piperidinyl]-

1-[4-[(4-Benzo[b]thien-2-yl-2-pyrimidinyl)amino]benzoyl]-4-(1-pyrrolidinyl)piperidine IKK-16 (IKK Inhibitor VII)

1-[4-[(4-Benzo[b]thien-2-yl-2-pyrimidinyl)amino]benzoyl]-4-(1-pyrrolidinyl)piperidine

IKK16;IKK-16;IKK INHIBITOR VII

CS-1847

IKK-16(free base)

[4-[[4-(1-benzothiophen-2-yl)pyrimidin-2-yl]amino]phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone

IKK 16 USP/EP/BP

Leucine-rich repeat kinase 2,Inhibitor,IKK 16,LRRK2,inhibit,IKK,I kappa B kinase,IκB kinase

(4-((4-(Benzo[b]thiophen-2-yl)pyrimidin-2-yl)amino)phenyl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone

IKK 16, 10 mM in DMSO

Abmole M2768-1mg IKK-16 873225-46-8

873225-46-8

NF-kB

IκB/IKK

Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds

Inhibitors