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Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)-

Product Name
Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)-
CAS No.
176957-55-4
Chemical Name
Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)-
Synonyms
CS-1839;CCTOO7093;CCT007093;CCT007093[C9369];CCT007093 ，S7485;CCT007093, 10 mM in DMSO;CCT-007093; CCT 007093; CCT007093;2,5-Bis(2-thienylmethylene)-cyclopentanone;(2E,5E)-2,5-Bis(2-thienylmethylene)cyclopentanone;2,5-bis(2-thienylMethylene)-, (E,E)-Cyclopentanone
CBNumber
CB92682247
Molecular Formula
C15H12OS2
Formula Weight
272.39
MOL File
176957-55-4.mol
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Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)- Property

Melting point:
222-223℃
storage temp. 
2-8°C
solubility 
DMSO: >3mg/mL
form 
powder, yellow
color 
Light yellow to green yellow
Sensitive 
Light Sensitive
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C9369
Product name
CCT007093
Purity
≥98% (HPLC), powder, yellow
Packaging
5mg
Price
$85.9
Updated
2025/07/31
Sigma-Aldrich
Product number
C9369
Product name
CCT007093
Purity
≥98% (HPLC), powder, yellow
Packaging
25mg
Price
$326
Updated
2025/07/31
Cayman Chemical
Product number
19992
Product name
CCT007093
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
19992
Product name
CCT007093
Purity
≥98%
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
19992
Product name
CCT007093
Purity
≥98%
Packaging
10mg
Price
$122
Updated
2024/03/01
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Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)- Chemical Properties,Usage,Production

Uses

Acts as a PPM1D inhibitor

Biological Activity

cct007093 is a small-molecule chemical inhibitor of ppm1d with ic50 value of 8.4μm [1].cct007093 is a thienylidene cyclopentanone and shows a potent inhibition of ppm1d in the in vitro assay when using the recombinant phospho-p38 as a substrate. in cellular assay, cct007093 shows specificity for mcf-7 cells over hela cells. it reduces 40% viability of the cells after 2 days. it is found that the cell death induced by cct007093 is dependent on p38 kinase activity. cct007093 mimics the effect of ppm1d rnai in activating p38 kinase. it induces p38 phosphorylation at 4 h post-exposure in mcf-7 cells and the loss of viability can be rescued by sb203580, the specific p38 inhibitor [1].

in vivo

CCT007093 (6.4 mg/kg) enhances liver regeneration and increases the survival rate of mice following major hepatectomy[1].

Animal Model:Wild-type mice[1].
Dosage:3.2 and 6.4 mg/kg.
Administration:Injected intraperitoneally 4 times (mice were sacrificed at 36 h post-PH).
Result:Significantly improved survival in mice following major hepatectomy (80% hepatectomy).
The level of PCNA was also significantly increased in the liver of CCT007093-treated mice at 36h, 48h and 72h post-PH.

target

WIP1

References

[1] rayter s, elliott r, travers j, rowlands mg, richardson tb, boxall k, jones k, linardopoulos s, workman p, aherne w, lord cj, ashworth a. a chemical inhibitor of ppm1d that selectively kills cells overexpressing ppm1d. oncogene. 2008 feb 14;27(8):1036-44.

Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)- Preparation Products And Raw materials

Raw materials

Preparation Products

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Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)- Suppliers

China 101 India 2 The Netherlands 1 United Kingdom 1 United States 17 Global 122
Axon Medchem BV
Tel
--
Fax
--
Email
info@axonmedchem.com
Country
The Netherlands
ProdList
477
Advantage
30
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View Lastest Price from Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)- manufacturers

Career Henan Chemical Co
Product
Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)- 176957-55-4
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-13

176957-55-4, Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)-Related Search:

8-Hydroxyquinoline CGP 57380 Necrostatin-1 UNC2881

  • (2E,5E)-2,5-Bis(2-thienylmethylene)cyclopentanone CCT007093
  • Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)-
  • CCT007093
  • (2E,5E)-2,5-Bis(2-thienylmethylene)cyclopentanone
  • (2E,5E)-2,5-Bis(thiophen-2-ylmethylene)cyclopentanone
  • CCTOO7093
  • 2,5-bis(2-thienylMethylene)-, (E,E)-Cyclopentanone
  • 2,5-Bis(2-thienylmethylene)-cyclopentanone
  • (2Z,5E)-2,5-bis(thiophen-2-ylmethylidene)cyclopentan-1-one
  • CCT-007093; CCT 007093; CCT007093
  • CS-1839
  • Cyclopentanone, 2,5-bis(2-thienylmethylene)-, (2E,5E)-
  • (2E,5E)-2,5-bis(thiophen-2-ylmethylidene)cyclopentan-1-one
  • CCT-007093,inhibit,CCT007093,Phosphatase,CCT 007093,Apoptosis,Inhibitor,Autophagy
  • (2E,5E)-2,5-Bis(thiophen-2-ylmethylene)cyclopentan-1-one
  • CCT007093, 10 mM in DMSO
  • CCT007093[C9369]
  • CCT007093 ，S7485
  • 176957-55-4
  • Inhibitors