ChemicalBook > CAS DataBase List > Elamipretide

Elamipretide

Description

Product Name: Elamipretide
CAS No.: 736992-21-5
Chemical Name: Elamipretide
Synonyms: MTP-131;Centanafadine;SS-31, Elamipretide;Elamipretide acetate;RX-31;SS-31);Bendavia);Elamipretide;SS-31 10mg/20mg;ELAMIPRETIDE, >99%
CBNumber: CB92708860
Molecular Formula: C32H49N9O5
Formula Weight: 639.79
MOL File: 736992-21-5.mol

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Elamipretide Property

Density: 1.34±0.1 g/cm3(Predicted)
solubility: Methanol (Slightly), Water (Slightly)
pka: 10.10±0.25(Predicted)
form: Solid
color: White to Off-White
Sequence: H-d-Arg-dimethylTyr-Lys-Phe-NH2
Stability:: Hygroscopic
InChIKey: SFVLTCAESLKEHH-WKAQUBQDSA-N
SMILES: C(N)(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC1=C(C)C=C(O)C=C1C)NC(=O)[C@@H](CCCNC(N)=N)N

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

DC Chemicals

Product number: DC21695
Product name: Elamipretide(TFAsalt)
Purity: >98%
Packaging: 100mg
Price: $950
Updated: 2021/12/16

DC Chemicals

Product number: DC21695
Product name: Elamipretide(TFAsalt)
Purity: >98%
Packaging: 1g
Price: $3800
Updated: 2021/12/16

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Elamipretide Chemical Properties,Usage,Production

Description

Elamipretide, also known as MTP 131, is a mitochondria-targeted peptide antioxidant. Elamipretide decreases inflammation and protect against a variety of neurological illnesses. Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice. Elamipretide Promotes Mitophagosome Formation and Prevents Its Reduction Induced by Nutrient Excess in INS1 β-cells.

Uses

D-Arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide-d5 Trifluoroacetic Acid Salt is labelled D-Arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide (A769700) which is a mitochondrial-targeted compound that re-energizes ischemic mitochondria by interacting with cardiolipin. It is a cell-permeable antioxidant peptide.

Mechanism of action

Elamipretide can inhibit the production of pathogenic ROS (reactive oxygen species) and restore mitochondrial ATP synthesis. Currently, the most accepted mechanism for these two actions is the direct interaction between Elamipretide and cardiolipin.

Clinical Use

Barth syndrome is an ultra-rare genetic condition characterized by cardiac abnormalities leading to exercise intolerance, muscle weakness, debilitating fatigue, heart failure, recurrent infections, and delayed growth. There are currently no FDA- or EMA-approved therapies for patients with Barth syndrome. Elamipretide has an Orphan Drug, Fast Track and Rare Pediatric Designation from the FDA and Orphan Drug Designation from the EMA for treating Barth syndrome.

Side effects

Side effects of elamipretide include:
Mild redness or itching at the injection site
Headache
Dizziness

Description

Elamipretide Synthetic is a single, non-glycosylated polypeptide chain containing 4 amino acids, having a molecular mass of 640 Dalton and a Molecular formula of C₃₂H₄₉N₉O_{5 .}

Elamipretide Preparation Products And Raw materials

Raw materials

Preparation Products

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Elamipretide Suppliers

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View Lastest Price from Elamipretide manufacturers

Jinan Million Pharmaceutical Co., Ltd

Product: Elamipretide 736992-21-5
Price: US $1.00/kg
Min. Order: 0.00000016kg
Purity: 99%
Supply Ability: 200kg
Release date: 2025-11-07

Jinan Million Pharmaceutical Co., Ltd

Product: Elamipretide 736992-21-5
Price: US $1.00/kg
Min. Order: 0.10000000kg
Purity: 99%
Supply Ability: 200kg
Release date: 2025-11-07

Jinan Million Pharmaceutical Co., Ltd

Product: Elamipretide 736992-21-5
Price: US $1.00/kg
Min. Order: 0.10000000kg
Purity: 99%
Supply Ability: 200kg
Release date: 2025-11-07

736992-21-5, ElamipretideRelated Search:

Hexapeptide-11 L-Cysteine, L-cysteinylglycyl-L-glutaminyl-L-arginyl-L-α-glutamyl-L-threonyl-L-prolyl-L-α-glutamylglycyl-L-alanyl-L-α-glutamyl-L-alanyl-L-lysyl-L-prolyl-L-tryptophyl-L-tyrosyl-, cyclic (1→17)-disulfide DERMASEPTIN PHYLLOMEDUSA SAUVAGII Vantas Eptifibatide Acetate DSIP Ipamorelin 2'-Deoxyadenosine Bithionol Octamethylcyclotetrasiloxane

D-Arginyl-2,6-diMethyl-L-tyrosyl-L-lysyl-L-phenylalaninaMide

Elamipretide

Centanafadine

L-Phenylalaninamide, D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-

Elamipretide (TFA salt)

SS-31;MTP-131;BENDAVIA

Bendavia)

Elamipretide (SS-31

MTP-131

ELAMIPRETIDE, >99%

Elamipretide,MTP-131,RX-31,SS-31, >99%

Elamipretide (MTP-131

ELAMIPRETIDE (MTP-131;RX-31;SS-31)

RX-31

SS-31)

SS-31, Elamipretide

Elamipretide acetate

Elamipretide (SS-31) acetate

(S)-6-Amino-N-((S)-1-amino-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-((R)-2-amino-5-guanidinopentanamido)-3-(4-hydroxy-2,6-dimethylphenyl)propanamido)hexanamide

Elamipretide（HY-P0125

Elamipretide、SS-31、H2N-D-Arg-Dmt-Lys-Phe-NH2

SS-31 10mg/20mg

Elamipretide (MTP-131, SS-31)

Elamipretide (MTP-131) ，S9803

736992-21-5