Elamipretide
- Product Name
- Elamipretide
- CAS No.
- 736992-21-5
- Chemical Name
- Elamipretide
- Synonyms
- MTP-131;Centanafadine;SS-31, Elamipretide;Elamipretide acetate;RX-31;SS-31);Bendavia);Elamipretide;ELAMIPRETIDE, >99%;Elamipretide (SS-31
- CBNumber
- CB92708860
- Molecular Formula
- C32H49N9O5
- Formula Weight
- 639.79
- MOL File
- 736992-21-5.mol
Elamipretide Property
- Density
- 1.34±0.1 g/cm3(Predicted)
- solubility
- Methanol (Slightly), Water (Slightly)
- pka
- 10.10±0.25(Predicted)
- form
- Solid
- color
- White to Off-White
- Sequence
- H-d-Arg-dimethylTyr-Lys-Phe-NH2
- Stability:
- Hygroscopic
- InChIKey
- SFVLTCAESLKEHH-WKAQUBQDSA-N
- SMILES
- C(N)(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC1=C(C)C=C(O)C=C1C)NC(=O)[C@@H](CCCNC(N)=N)N
N-Bromosuccinimide Price
- Product number
- DC21695
- Product name
- Elamipretide(TFAsalt)
- Purity
- >98%
- Packaging
- 100mg
- Price
- $950
- Updated
- 2021/12/16
- Product number
- DC21695
- Product name
- Elamipretide(TFAsalt)
- Purity
- >98%
- Packaging
- 1g
- Price
- $3800
- Updated
- 2021/12/16
Elamipretide Chemical Properties,Usage,Production
Description
Elamipretide, also known as MTP 131, is a mitochondria-targeted peptide antioxidant. Elamipretide decreases inflammation and protect against a variety of neurological illnesses. Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice. Elamipretide Promotes Mitophagosome Formation and Prevents Its Reduction Induced by Nutrient Excess in INS1 β-cells.
Uses
D-Arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide-d5 Trifluoroacetic Acid Salt is labelled D-Arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide (A769700) which is a mitochondrial-targeted compound that re-energizes ischemic mitochondria by interacting with cardiolipin. It is a cell-permeable antioxidant peptide.
Mechanism of action
Elamipretide can inhibit the production of pathogenic ROS (reactive oxygen species) and restore mitochondrial ATP synthesis. Currently, the most accepted mechanism for these two actions is the direct interaction between Elamipretide and cardiolipin.
Clinical Use
Barth syndrome is an ultra-rare genetic condition characterized by cardiac abnormalities leading to exercise intolerance, muscle weakness, debilitating fatigue, heart failure, recurrent infections, and delayed growth. There are currently no FDA- or EMA-approved therapies for patients with Barth syndrome. Elamipretide has an Orphan Drug, Fast Track and Rare Pediatric Designation from the FDA and Orphan Drug Designation from the EMA for treating Barth syndrome.
Side effects
Side effects of elamipretide include:
Mild redness or itching at the injection site
Headache
Dizziness
Elamipretide Preparation Products And Raw materials
Raw materials
Preparation Products
Elamipretide Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from Elamipretide manufacturers
- Product
- Elamipretide 736992-21-5
- Price
- US $3900.00-3500.00/g
- Min. Order
- 0.0010000000474974513g
- Purity
- 99%
- Supply Ability
- 5000
- Release date
- 2024-08-09
- Product
- SS-31 736992-21-5
- Price
- US $0.00-0.00/box
- Min. Order
- 1box
- Purity
- 99.99%
- Supply Ability
- 10000
- Release date
- 2024-10-29
- Product
- Elamipretide 736992-21-5
- Price
- US $0.00-0.00/G
- Min. Order
- 1G
- Purity
- 99%
- Supply Ability
- 1 ton/year
- Release date
- 2025-02-04