ChemicalBook > CAS DataBase List > SH-4-54

SH-4-54

Product Name
SH-4-54
CAS No.
1456632-40-8
Chemical Name
SH-4-54
Synonyms
SH-4-54;CS-1773;SH-4-54 USP/EP/BP;SH 4 54,Inhibitor,SH454,inhibit,STAT;4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-benzoic acid;Benzoic acid, 4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-;4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-Benzoic Acid SH-4-54
CBNumber
CB92729656
Molecular Formula
C29H27F5N2O5S
Formula Weight
610.59
MOL File
1456632-40-8.mol
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SH-4-54 Property

Boiling point:
717.2±70.0 °C(Predicted)
Density 
1.431±0.06 g/cm3(Predicted)
storage temp. 
Desiccate at -20°C
solubility 
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 20 mg/ml
form 
A crystalline solid
pka
4.29±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
25982
Product name
SH-4-54
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
25982
Product name
SH-4-54
Purity
≥98%
Packaging
5mg
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
25982
Product name
SH-4-54
Purity
≥98%
Packaging
10mg
Price
$199
Updated
2024/03/01
Cayman Chemical
Product number
25982
Product name
SH-4-54
Purity
≥98%
Packaging
25mg
Price
$381
Updated
2024/03/01
TRC
Product number
C984505
Product name
4-[[(4-Cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]benzoicAcid
Packaging
25mg
Price
$510
Updated
2021/12/16
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SH-4-54 Chemical Properties,Usage,Production

Description

SH-4-54 is an inhibitor of signal transducer and activator of transcription 3 (STAT3; IC50 = 4.7 μM for STAT3 homodimer DNA binding activity). It selectively inhibits STAT3 homodimer over STAT1 and STAT5 homodimer and STAT3:STAT1 heterodimer DNA binding in EGF-stimulated NIH3T3/hEGFR nuclear extracts containing activated STAT1, STAT3, and STAT5 and decreases STAT3 iNOS, Survivin, and Bcl-2 promoter occupancy in MDA-MB-231 cells. SH-4-54 inhibits growth of glioma, breast, and prostate cancer cell lines that express constitutively active STAT3 (IC50s = 1-7.4, 3.8-4.5, and 5.3-5.8 μM, respectively). In vivo, SH-4-54 (3 mg/kg per day) inhibits tumor growth in the U251MG glioma and MDA-MB-231 breast cancer mouse xenograft models.

Uses

4-[[(4-Cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]benzoic Acid acts as a STAT 3 and STAT5 inhibitor. STAT 3 is unusually active in glioblastoma and plays a crucial role in tumor growth

SH-4-54 Preparation Products And Raw materials

Raw materials

Preparation Products

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SH-4-54 Suppliers

China 77 India 1 United States 10 Global 88
Shanghai Boyle Chemical Co., Ltd.
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View Lastest Price from SH-4-54 manufacturers

Hebei Mingeng Biotechnology Co., Ltd
Product
SH-4-54 1456632-40-8
Price
US $200.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg/Months
Release date
2022-11-20

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  • 4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-Benzoic Acid SH-4-54
  • SH-4-54
  • 4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-benzoic acid
  • Benzoic acid, 4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-
  • CS-1773
  • SH-4-54 USP/EP/BP
  • SH 4 54,Inhibitor,SH454,inhibit,STAT
  • 1456632-40-8
  • C29H27F5N2O5S
  • Inhibitors
  • API