SH-4-54

ChemicalBook > CAS DataBase List > SH-4-54

Product Name: SH-4-54
CAS No.: 1456632-40-8
Chemical Name: SH-4-54
Synonyms: SH-4-54;CS-1773;SH-4-54 USP/EP/BP;SH 4 54,Inhibitor,SH454,inhibit,STAT;4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-benzoic acid;Benzoic acid, 4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-;4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-Benzoic Acid SH-4-54
CBNumber: CB92729656
Molecular Formula: C29H27F5N2O5S
Formula Weight: 610.59
MOL File: 1456632-40-8.mol

Less

SH-4-54 Property

Boiling point:: 717.2±70.0 °C(Predicted)
Density: 1.431±0.06 g/cm3(Predicted)
storage temp.: Desiccate at -20°C
solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 20 mg/ml
form: A crystalline solid
pka: 4.29±0.10(Predicted)
color: White to off-white

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 25982
Product name: SH-4-54
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 25982
Product name: SH-4-54
Purity: ≥98%
Packaging: 5mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 25982
Product name: SH-4-54
Purity: ≥98%
Packaging: 10mg
Price: $199
Updated: 2024/03/01

Cayman Chemical

Product number: 25982
Product name: SH-4-54
Purity: ≥98%
Packaging: 25mg
Price: $381
Updated: 2024/03/01

TRC

Product number: C984505
Product name: 4-[[(4-Cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]benzoicAcid
Packaging: 2.5mg
Price: $130
Updated: 2021/12/16

Less

SH-4-54 Chemical Properties,Usage,Production

Description

SH-4-54 is an inhibitor of signal transducer and activator of transcription 3 (STAT3; IC₅₀ = 4.7 μM for STAT3 homodimer DNA binding activity). It selectively inhibits STAT3 homodimer over STAT1 and STAT5 homodimer and STAT3:STAT1 heterodimer DNA binding in EGF-stimulated NIH3T3/hEGFR nuclear extracts containing activated STAT1, STAT3, and STAT5 and decreases STAT3 iNOS, Survivin, and Bcl-2 promoter occupancy in MDA-MB-231 cells. SH-4-54 inhibits growth of glioma, breast, and prostate cancer cell lines that express constitutively active STAT3 (IC₅₀s = 1-7.4, 3.8-4.5, and 5.3-5.8 μM, respectively). In vivo, SH-4-54 (3 mg/kg per day) inhibits tumor growth in the U251MG glioma and MDA-MB-231 breast cancer mouse xenograft models.

Uses

4-[[(4-Cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]benzoic Acid acts as a STAT 3 and STAT5 inhibitor. STAT 3 is unusually active in glioblastoma and plays a crucial role in tumor growth

SH-4-54 Preparation Products And Raw materials

Raw materials

Preparation Products

Less

SH-4-54 Suppliers

China 79 India 1 United States 11 Global 91

Chengdu Celes Technology Co., Ltd

Tel: 17323066073
Email: 2538834896@qq.com
Country: China
ProdList: 79
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: meilunui@163.com
Country: China
ProdList: 4727
Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

HangZhou YuHao Chemical Technology Co., Ltd.

Tel: 0571-82693216
Fax: 0571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 2028
Advantage: 58

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2990
Advantage: 60

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4512
Advantage: 55

Shanghaizehan biopharma technology co., Ltd.

Tel: 021-61350663 13052117465
Fax: 021-61350662
Email: sales@zehanbiopharma.com
Country: China
ProdList: 1009
Advantage: 55

Struchem Co., Ltd.

Tel: 0512-0512-63009836 15365350169
Fax: 0512-63006936
Email: helen@struchem.com
Country: China
ProdList: 3984
Advantage: 60

Guangzhou Zhiya Chemdrugs Co.,Ltd

Tel: 18122150900
Fax: QQ:2869377561
Email: sculk28@163.com
Country: China
ProdList: 646
Advantage: 55

Wuhan ChemFaces Biochemical Co., Ltd.

Tel: 18607101326 15172504745
Fax: +86-27-84254680
Email: aileen@chemfaces.com
Country: China
ProdList: 7059
Advantage: 55

Chengdu DingDang Pharmaceutical Co., Ltd.

Tel: 028-86040038 13980902949;
Fax: 028-85149890
Email: market@dingdangchem.com
Country: China
ProdList: 1843
Advantage: 55

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3866
Advantage: 58

Shanghai Rechem science Co., Ltd.

Tel: 21-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2992
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 7267
Advantage: 58

Shanghai SuperLan Chemcial Technique Centre

Tel: 021-2022843681 15618226720
Fax: +86-21-51601218
Email: lucy@atkchemical.com
Country: China
ProdList: 9204
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 29785
Advantage: 68

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Medi-tech Bioscientific Co., Ltd.

Tel: 0519-83246372 13585352506
Fax: 0519-83246372
Country: China
ProdList: 1844
Advantage: 58

Chuzhou KeMail Chemical Technology Co., Ltd

Tel: 0550-5196001 15000891977
Fax: 0550-5196001
Email: wj520wjxby@126.com
Country: China
ProdList: 1847
Advantage: 55

Shanghai Biopharmaleader Co., Ltd.

Tel: +86 18721201413
Fax: +86 (21) 5775-8967
Email: sales@biopharmaleader.com
Country: China
ProdList: 1720
Advantage: 58

Shanghai BetterBioChem Co., Ltd.

Tel: +86-18017644823
Fax: - QQ：1910610264
Email: sales@betterbiochem.com
Country: China
ProdList: 325
Advantage: 58

Chengdu Henghui Pharmaceutical Co., Ltd.

Tel: 86-028-89481236 13540674322 15828370308
Fax: 86-028-89481236
Country: China
ProdList: 96
Advantage: 58

Angel Pharmatech, Ltd.

Tel: 17317130613
Fax: QQ3358272972
Email: 3358272972@qq.com
Country: China
ProdList: 3251
Advantage: 58

Nanjing Digger Medical Technology Co. Ltd.

Tel: 025-025-51191215 18013836722
Fax: 025-51191215
Email: 2399235533@qq.com
Country: China
ProdList: 4933
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

Guangzhou Tomums Life Science Co., Ltd.

Tel: 020-31155029 18902330969
Fax: 020-31155029
Email: sales@tomums.cn
Country: China
ProdList: 4696
Advantage: 58

Taizhou Crene Biotechnology Co. Ltd.

Tel: +86-0576-88813233 +86-13396860566
Email: sales@pharm-intermediates.com
Country: China
ProdList: 1990
Advantage: 58

Zhejiang J&C Biological Technology Co.,Limited

Tel: +1-2135480471 +1-2135480471
Email: sales@sarms4muscle.com
Country: China
ProdList: 10473
Advantage: 58

Dideu Industries Group Limited

Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Country: China
ProdList: 22883
Advantage: 58

HANGZHOU CLAP TECHNOLOGY CO.,LTD

Tel: 86-571-88216897,88216896 13588875226
Fax: 86-571-88216895
Email: sales@hzclap.com
Country: CHINA
ProdList: 6312
Advantage: 58

DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
ProdList: 9409
Advantage: 58

Changzhou Chenhong Biotechnology Co., Ltd.

Tel: 0519-85788828 13775037613
Email: sales@chemrenpharm.com
Country: China
ProdList: 3600
Advantage: 58

Shanghai Zeye Biotechnology Co., Ltd.

Tel: 021-61998551 13122364865
Email: sale1@shzysw.net
Country: China
ProdList: 9772
Advantage: 58

Absin Bioscience Inc.

Tel: 021-38015121 15000105423
Email: wulan@absin.cn
Country: China
ProdList: 24731
Advantage: 58

Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
ProdList: 5132
Advantage: 58

Shanghai Luofa Biochemical Technology Co., Ltd.

Tel: 021-51111890 15317326293
Email: sales@molnova.com
Country: China
ProdList: 4195
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44808
Advantage: 58

Wuhan Yanzhe Technology Co., Ltd

Tel: 15527250409
Fax: QQ：2692360204
Email: wenhaotian12@163.com
Country: China
ProdList: 4495
Advantage: 58

cjbscvictory

Tel: 13348960310 13348960310
Email: 3003867561@qq.com
Country: China
ProdList: 10002
Advantage: 58

Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Tel: 021-51816796-820 13611835272
Fax: 021-5161 3951
Email: sales2@sunwaypharm.com
Country: China
ProdList: 44458
Advantage: 58

Abmole Bioscience Inc.

Tel: 021-50967598 02150967598
Email: sales@abmole.cn
Country: China
ProdList: 4494
Advantage: 58

Shanghai tingchong biology science and technology co., ltd

Tel: 18964309092 18964309092
Email: 2769493375@qq.com
Country: China
ProdList: 2634
Advantage: 58

Nantong Feiyu Biological Technology CO.,LTD

Tel: 0513-68819626; 15152877458
Fax: 0513-68669626
Email: feiyubio@163.com
Country: China
ProdList: 4819
Advantage: 58

Hubei Kele Fine Chemical Co., Ltd

Tel: 027-59101668 19945030958
Fax: 027-59101668
Email: 2881924765@qq.com
Country: China
ProdList: 8140
Advantage: 58

ChemeGen 中国

Tel: 18818260767
Fax: QQ 3610331285
Email: 2625930290@qq.com
Country: China
ProdList: 6973
Advantage: 58

Wuhan Augda Biotechnology Co., Ltd

Tel: 15071299552
Fax: QQ:262933239
Email: 262933239@qq.com
Country: China
ProdList: 6883
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 62163
Advantage: 58

InvivoChem

Tel: 13549236410
Email: sales@invivochem.cn
Country: China
ProdList: 6753
Advantage: 58

Shanghai Moqi Biological Technology Co., LTD

Tel: 021-38218169 13341702378
Email: 190129269@qq.com
Country: China
ProdList: 9126
Advantage: 58

Less

View Lastest Price from SH-4-54 manufacturers

Hebei Mingeng Biotechnology Co., Ltd

Product: SH-4-54 1456632-40-8
Price: US $200.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg/Months
Release date: 2022-11-20

1456632-40-8, SH-4-54Related Search:

SH5-07 SHA 68 GDC-0084 Osimertinib mesylate Tazemetostat (EPZ-6438) Niraparib Mertansine (S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate Enasidenib Ivosidenib ABBV-075 Ponatinib Selonsertib AZD 1480 Fludarabine EW-7197 HO-3867 Fedratinib

4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-Benzoic Acid SH-4-54

SH-4-54

4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-benzoic acid

Benzoic acid, 4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-

CS-1773

SH-4-54 USP/EP/BP

SH 4 54,Inhibitor,SH454,inhibit,STAT

1456632-40-8

C29H27F5N2O5S

Inhibitors

API