6-Chloro-3-methyluracil

Product Name: 6-Chloro-3-methyluracil
CAS No.: 4318-56-3
Chemical Name: 6-Chloro-3-methyluracil
Synonyms: 6-chloro-3-methylpyrimidine-2,4(1H,3H)-dione;3-METHYL-6-CHLOROURACIL;6-chloro-2-hydroxy-3-MethylpyriMidin-4(3H)-one;Chloro-3-Methylura;6-Chloro-3-Methyuracil;3-METHYL-6-CHLOROURACI;Alogliptin Impurity 86;6-Chloro-3-methyluraci;6-CHLORO-3-METHYLURACIL;6-Chloro-3-dimethyl uracil
CBNumber: CB9283127
Molecular Formula: C5H5ClN2O2
Formula Weight: 160.56
MOL File: 4318-56-3.mol

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6-Chloro-3-methyluracil Property

Melting point:: 278-280°C (dec.)
Density: 0,896 gr/cm
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: powder to crystal
pka: 7.16±0.40(Predicted)
color: White to Almost white
BRN: 511456
InChI: InChI=1S/C5H5ClN2O2/c1-8-4(9)2-3(6)7-5(8)10/h2H,1H3,(H,7,10)
InChIKey: SGLXGFAZAARYJY-UHFFFAOYSA-N
SMILES: C1(=O)NC(Cl)=CC(=O)N1C
CAS DataBase Reference: 4318-56-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
RIDADR: UN 1992
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 713465
Product name: 6-Chloro-3-methyluracil
Purity: ≥98%
Packaging: 100g
Price: $300
Updated: 2025/07/31

TCI Chemical

Product number: C2300
Product name: 6-Chloro-3-methyluracil
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $36
Updated: 2025/07/31

TCI Chemical

Product number: C2300
Product name: 6-Chloro-3-methyluracil
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $111
Updated: 2025/07/31

TRC

Product number: C369665
Product name: 6-Chloro-3-methyluracil
Packaging: 10g
Price: $120
Updated: 2021/12/16

Usbiological

Product number: 162126
Product name: 6-Chloro-3-methyluracil
Packaging: 10g
Price: $403
Updated: 2021/12/16

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6-Chloro-3-methyluracil Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

6-Chloro-3-methyluracil have been used in the synthesis of antibacterial agents as inhibitors of Helicobacter pylori glutamate racemase.

Definition

ChEBI: 6-Chloro-3-methyluracil is a member of pyrimidines and an organohalogen compound.

Synthesis

2565-47-1

4318-56-3

General procedure for the synthesis of 3-methyl-6-chlorouracil from 1-methylpyrimidine-2,4,6(1H,3H,5H)-trione: Water (2.7 mL) was added slowly and dropwise at 0 °C to a 1-methylpyrimidine-2,4,6(1H,3H,5H)-trione (14.2 g, 100 mmol) formed with phosphorus oxychloride (POCl3, 95 mL) in a in a suspension. Subsequently, the reaction mixture was warmed to 80 °C and maintained for 5 hours. Upon completion of the reaction, the resulting brown solution was cooled and the POCl3 was evaporated under reduced pressure.The residue was treated with methanol (MeOH) and the resulting solid was purified by recrystallization from ethanol to give 11.5 g of 3-methyl-6-chlorouracil (yield: 71.6%). The melting point of the product was 279-282 °C (decomposition), which is consistent with literature values (280-282 °C).1H NMR (400 MHz, DMSO-d6) δ 3.10 (s, 3H), 5.90 (s, 1H), 12.4 (br s, 1H).

References

[1] Journal of Heterocyclic Chemistry, 2014, vol. 51, # 3, p. 594 - 597
[2] Tetrahedron Asymmetry, 1997, vol. 8, # 14, p. 2319 - 2323
[3] Patent: WO2009/73210, 2009, A1. Location in patent: Page/Page column 76
[4] Patent: WO2006/133261, 2006, A2. Location in patent: Page/Page column 30
[5] Patent: WO2007/143705, 2007, A2. Location in patent: Page/Page column 23

6-Chloro-3-methyluracil Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Chloro-3-methyluracil Suppliers

Americas 1 Canada 2 China 557 Europe 4 France 2 Germany 5 India 52 Japan 3 Slovakia 2 Switzerland 2 The Netherlands 1 United Kingdom 25 United States 48 Global 704

Interchim SA

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Email: him@interchim.com
Country: France
ProdList: 2725
Advantage: 58

Interchim S.A.

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Email: interchim@interchim.com
Country: France
ProdList: 6302
Advantage: 76

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View Lastest Price from 6-Chloro-3-methyluracil manufacturers

Handan City Zechi trading Co., LTD

Product: 6-Chloro-3-methyluracil 4318-56-3
Price: US $1.00/g
Min. Order: 100g
Purity: 99
Supply Ability: 1000
Release date: 2025-08-11

Hebei Chuanghai Biotechnology Co., Ltd

Product: 6-Chloro-3-methyluracil 4318-56-3
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2025-06-27

Dideu Industries Group Limited

Product: 6-Chloro-3-methyluracil 4318-56-3
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2025-04-09

4318-56-3, 6-Chloro-3-methyluracilRelated Search:

tert-Butyldimethylsilyl chloride METSULFURON METHYL Methyl acetate 4-(Chloromethyl)benzoic acid 2-Chloro-5-chloromethylpyridine CHLOROMETHYLPHENYLSILANE Methyl acrylate Uracil Bensulfuron methyl DIMETHYLTHEXYLSILYL CHLORIDE Chloromethyltrimethylsilane Methylparaben Kresoxim-methyl 2-Pyridinamine, 6-chloro-5-methyl Thiophanate-methyl Methyl Parathion-methyl Methyl bromide

6-chloro-3-methyl-2,4(1H,3H)-pyrimidinedione

6-chloro-3-methylpyrimidine-2,4(1H,3H)-dione

6-Chloro-3-dimethyl uracil

3-METHYL-6-CHLOROURACI

6-Chloro-3-Methyuracil

3-Methyl-6-chlorouracil, GC 97%

3-METHYL-6-CHLOROURACIL

6-CHLORO-3-METHYLURACIL

6-CHLORO-3-METHYLURACIL, 98+%

6-Chloro-3-methyluracil ,99%

2,4(1H,3H)-pyrimidinedione, 6-chloro-3-methyl-

6-chloro-3-Methyl-1,2,3,4-tetrahydropyriMidine-2,4- dione

6-chloro-3-trideuterioMethyluracil

6-chloro-2-hydroxy-3-MethylpyriMidin-4(3H)-one

6-Chloro-3-methylpyrimidine-2,4(1H,3H)-dione, 4-Chloro-2,6-dioxo-1-methyl-1,2,3,6-tetrahydropyrimidine

Alogliptin Benzoate interMediate D

Chloro-3-Methylura

6-chloro-3-methyl-1H-pyrimidine-2,4-dione

Uracil, 6-chloro-3-methyl-

6-chloro-3-methyl-1H-pyrimidine-2,4(1H,3H)-dione

2-(propan-2-ylthio)ethanol

6-Chloro-3-methyluracil &gt

Alogliptin Impurity 86

Trelagliptin & Alogliptin intermediates，6-Chloro-3-methyluracil

Alogliptin Intermediate 4 OR Trelagliptin Intermediate

6-Chloro-3-Methyluracil / Trelagliptin Intermediate / Alogiptin Intermeidate

2-[2-oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1-yl)ethyl]isoindole-1,9-dione

Alogliptin intermediate 3-Methyl-6-Chlorouracil

6-Chloro 3-Methyl Uracil Impurity

6-Chloro-3-methyluracil , 95%

6-Chloro-3-methyluraci

4318-56-3

4138-56-3

C5H5N2O2Cl

C5H5ClN3O2

C5H5ClN2O2

Intermediates

Pyrimidine

Biochemistry

Nucleobases and their analogs

Nucleosides, Nucleotides & Related Reagents

API

4318-56-3