2,5-Dimethylindole Property

Melting point:

112-113 °C (lit.)

Boiling point:

254.33°C (rough estimate)

Density 

1.0353 (rough estimate)

refractive index 

1.5000 (estimate)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

soluble in Methanol

form 

Solid

pka

17.75±0.30(Predicted)

color 

Off-white to pale pink or light brown

CAS DataBase Reference

1196-79-8(CAS DataBase Reference)

NIST Chemistry Reference

1H-indole, 2,5-dimethyl-(1196-79-8)

Safety

Hazard Codes 

Xi

Risk Statements 

37/38-41

Safety Statements 

26-39

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

29339900

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

2,5-Dimethylindole Chemical Properties,Usage,Production

Description

2, 5-Dimethylindole is a kind of carbazole-system derived indole compound, which is valuable in the manufacturing of perfume. It is also a useful chemical intermediate. It is usually used as reactant in the following reaction: stereoselective synthesis of indolines via palladium-catalyzed asymmetric hydrogenation of unprotected indoles; stereoselective preparation of substituted indoles via rhodium-catalyzed enantioselective coupling reaction of indoles with diazo compounds; enantioselective synthesis of fluorene derivatives via Friedel-Crafts reactions; preparation of bis-indolyldihydroxybenzoquinones by addition indoles to dichlorobenzoquinone promoted by Bronsted acid; Reaction with hydroxypyrazolines.

Sources

https://www.sigmaaldrich.com/catalog/product/aldrich/d166006?lang=en&region=US
https://books.google.com/books?isbn=0470188073

Chemical Properties

Off-white to pale pink or light brown solid

Uses

• Reactant in stereoselective preparation of substituted indoles via rhodium-catalyzed enantioselective coupling reaction of indoles with diazo compounds
• Reactant in stereoselective synthesis of indolines via palladium-catalyzed asymmetric hydrogenation of unprotected indoles
• Reactant in enantioselective synthesis of fluorene derivatives via Friedel-Crafts reactions
• Reactant in preparation of bis-indolyldihydroxybenzoquinones by addition indoles to dichlorobenzoquinone promoted by Bronsted acid
• Reactant in reaction with hydroxypyrazolines