ChemicalBook > CAS DataBase List > Terazosin hydrochloride

Terazosin hydrochloride

Product Name
Terazosin hydrochloride
CAS No.
63074-08-8
Chemical Name
Terazosin hydrochloride
Synonyms
Itrin;HYTRIN;Hitrin;Vicard;Blavin;Dysalfa;Flotrin;Heitrin;Hytrine;Olyster
CBNumber
CB9285510
Molecular Formula
C19H26ClN5O4
Formula Weight
423.9
MOL File
63074-08-8.mol
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Terazosin hydrochloride Property

Melting point:
261-263°C
storage temp. 
Inert atmosphere,2-8°C
solubility 
H2O: 25 mg/mL
form 
powder
color 
white to off-white
Water Solubility 
Soluble in water at 20mg/ml. Also soluble in methanol or ethanol.
Stability:
Stable for 2 years as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
CAS DataBase Reference
63074-08-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
TK8044925
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T4680
Product name
Terazosin hydrochloride
Purity
≥98% (TLC), powder
Packaging
50mg
Price
$211
Updated
2024/03/01
Sigma-Aldrich
Product number
T4680
Product name
Terazosin hydrochloride
Purity
≥98% (TLC), powder
Packaging
250mg
Price
$368
Updated
2024/03/01
Alfa Aesar
Product number
J62055
Product name
Terazosin hydrochloride
Purity
99+%
Packaging
50mg
Price
$131
Updated
2023/06/20
Cayman Chemical
Product number
20216
Product name
Terazosin (hydrochloride)
Purity
≥98%
Packaging
100mg
Price
$110
Updated
2024/03/01
Cayman Chemical
Product number
20216
Product name
Terazosin (hydrochloride)
Purity
≥98%
Packaging
250mg
Price
$218
Updated
2024/03/01
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Terazosin hydrochloride Chemical Properties,Usage,Production

Description

Terazosin hydrochloride is a highly water-soluble antihypertensive agent with a structure and profile closely related to that of prazosin.

Originator

Abbott (USA)

Uses

An α-1-adrenergicblocker related to prazosin.

Uses

Terazosin hydrochloride has been used for orthogonality and similarity analysis using reversed-phase chromatographic studies5. Furthermore, terazosin has also been used for the evaluation of chemometric techniques to determine orthogonality and similarity in chromatographic methods6.

Uses

Hytrin (Abbott).

brand name

Terazosin is INN and BAN;HEITRIN.

General Description

Terazosin hydrochloride, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine monohydrochloride (Hytrin), is a structuralcongener of prazosin hydrochloride. It possessessimilar selective properties of specifically inhibiting 1-adrenergic receptors. The drug is slightly less potent thanprazosin hydrochloride. Terazosin hydrochloride has a halflifeof approximately 12 hours, which is much longer thanthat of prazosin. This lends itself to a once-daily dose tocontrol hypertension in many patients.

Biological Activity

α 1 - and α 2B -adrenoceptor antagonist (K i values are 3.3, 0.7, 1.1, 7.7, 1510 and 78.2 nM for α 1A , α 1B , α 1D , α 2B , α 2A and α 2C receptors respectively). Antihypertensive following oral or intravenous administration in vivo .

Biochem/physiol Actions

α1-adrenoceptor antagonist.

storage

Store at RT

References

References/Citations 1) Hancock et al. (1995), Actions of terazosin and its enantiomers at subtypes of alpha-1 and alpha-2 adrenoceptors in vitro; Recept. Signal Transduct. Res., 15 863 2) Kyncl et al. (1986), Pharmacology of terazosin; Am. J. Med., 80 12 3) Shionoiri et al. (1994), Long-term therapy with terazosin may improve glucose and lipid metabolism in hypertensives: a multicenter prospective study; Am. J. Med. Sci., 307 Suppl 1 S91 4) Pan et al. (2003), Identification of apoptotic and antiangiogenic activities of terazosin in human prostate cancer and endothelial cells; J. Urol., 169 724 5) Chen et al. (2015), Terazosin activates Pgk1 and HSP90 to promote stress resistance; Nat. Chem. Biol., 11 19

Terazosin hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Terazosin
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Terazosin hydrochloride Suppliers

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View Lastest Price from Terazosin hydrochloride manufacturers

Baoji Guokang Bio-Technology Co., Ltd.
Product
Terazosin hydrochloride 63074-08-8
Price
US $121.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200T
Release date
2021-06-04
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
Terazosin hydrochloride 63074-08-8
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2020-11-17
Zhuozhou Wenxi import and Export Co., Ltd
Product
Terazosin hydrochloride 63074-08-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

63074-08-8, Terazosin hydrochlorideRelated Search:

TERAZOSIN HYDROCHLORIDE DIHYDRATE Cetirizine dihydrochloride Telmisartan 4-Amino-6,7-dimethoxyquinazoline Terazosin Quinazoline Terazosin hydrochloride TERAZOSIN HYDROCHLORIDE DIHYDRATEIMP. O (EP): 1,4-BIS[(TETRAHYDROFURAN-2-YL)CARBONYL]PIPERAZINE TERAZOSIN HYDROCHLORIDE DIHYDRATEIMP. N (EP): 1-[[(2RS)-TETRAHYDROFURAN-2-YL]CARBONYL]PIPERAZINE TERAZOSIN HYDROCHLORIDE DIHYDRATEIMP. K (EP) AS HYDROCHLORIDE:PRAZOSIN HYDROCHLORIDE TERAZOSIN HYDROCHLORIDE MONOHYDRATE TERAZOSIN HYDROCHLORIDE DIHYDRATEIMP. M (EP): 1,4-BIS(FURAN-2-YLCARBONYL)PIPERAZINE (R)-(+)-TERAZOSIN HYDROCHLORIDE DIHYDRATE Terazosin hydrochloride, anhydrous TERAZOSIN HYDROCHLORIDE DIHYDRATEIMP. L (EP): 1-(FURAN-2-YLCARBONYL)-PIPERAZINE TERAZOSIN HYDROCHLORIDE DIHYDRATEIMP. C (EP): 6,7-DIMETHOXY-2-(PIPERAZIN-1-YL)QUINAZOLIN-4-AMINE TERAZOSIN HYDROCHLORIDE DIHYDRATEIMP. A (EP): 2-CHLORO-6,7-DIMETHOXYQUINAZOLIN-4-AMINE

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