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Terazosin hydrochloride

Product Name
Terazosin hydrochloride
CAS No.
63074-08-8
Chemical Name
Terazosin hydrochloride
Synonyms
Itrin;HYTRIN;Hitrin;Vicard;Blavin;Dysalfa;Flotrin;Heitrin;Hytrine;Olyster
CBNumber
CB9285510
Molecular Formula
C19H26ClN5O4
Formula Weight
423.9
MOL File
63074-08-8.mol
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Terazosin hydrochloride Property

Melting point:
261-263°C
storage temp. 
Inert atmosphere,2-8°C
solubility 
H2O: 25 mg/mL
form 
powder
color 
white to off-white
Water Solubility 
Soluble in water at 20mg/ml. Also soluble in methanol or ethanol.
Stability:
Stable for 2 years as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
InChI
InChI=1S/C19H25N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22);1H
InChIKey
IWSWDOUXSCRCKW-UHFFFAOYSA-N
SMILES
NC1=NC(N2CCN(C(C3OCCC3)=O)CC2)=NC2=CC(OC)=C(OC)C=C12.Cl
CAS DataBase Reference
63074-08-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
TK8044925
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T4680
Product name
Terazosin hydrochloride
Purity
≥98% (TLC), powder
Packaging
50mg
Price
$217
Updated
2025/07/31
Sigma-Aldrich
Product number
T4680
Product name
Terazosin hydrochloride
Purity
≥98% (TLC), powder
Packaging
250mg
Price
$946
Updated
2025/07/31
Cayman Chemical
Product number
20216
Product name
Terazosin (hydrochloride)
Purity
≥98%
Packaging
100mg
Price
$110
Updated
2024/03/01
Cayman Chemical
Product number
20216
Product name
Terazosin (hydrochloride)
Purity
≥98%
Packaging
250mg
Price
$218
Updated
2024/03/01
Cayman Chemical
Product number
20216
Product name
Terazosin (hydrochloride)
Purity
≥98%
Packaging
500mg
Price
$352
Updated
2024/03/01
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Terazosin hydrochloride Chemical Properties,Usage,Production

Description

Terazosin hydrochloride is a highly water-soluble antihypertensive agent with a structure and profile closely related to that of prazosin.

Originator

Abbott (USA)

Uses

An α-1-adrenergicblocker related to prazosin.

Uses

Terazosin hydrochloride has been used for orthogonality and similarity analysis using reversed-phase chromatographic studies5. Furthermore, terazosin has also been used for the evaluation of chemometric techniques to determine orthogonality and similarity in chromatographic methods6.

Uses

Hytrin (Abbott).

brand name

Terazosin is INN and BAN;HEITRIN.

General Description

Terazosin hydrochloride, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine monohydrochloride (Hytrin), is a structuralcongener of prazosin hydrochloride. It possessessimilar selective properties of specifically inhibiting 1-adrenergic receptors. The drug is slightly less potent thanprazosin hydrochloride. Terazosin hydrochloride has a halflifeof approximately 12 hours, which is much longer thanthat of prazosin. This lends itself to a once-daily dose tocontrol hypertension in many patients.

Biological Activity

α 1 - and α 2B -adrenoceptor antagonist (K i values are 3.3, 0.7, 1.1, 7.7, 1510 and 78.2 nM for α 1A , α 1B , α 1D , α 2B , α 2A and α 2C receptors respectively). Antihypertensive following oral or intravenous administration in vivo .

Biochem/physiol Actions

α1-adrenoceptor antagonist.

storage

Store at RT

References

[1] A A HANCOCK. Actions of terazosin and its enantiomers at subtypes of alpha 1- and alpha 2-adrenoceptors in vitro.[J]. Journal of Receptors and Signal Transduction, 1995, 15 7-8: 863-885. DOI:10.3109/10799899509049862
[2] PH.D. J J K. Pharmacology of terazosin[J]. American Journal of Medicine, 1986, 80 5: Pages 12-19. DOI:10.1016/0002-9343(86)90846-6
[3] H SHIONOIRI. Long-term therapy with terazosin may improve glucose and lipid metabolism in hypertensives: a multicenter prospective study.[J]. American Journal of the Medical Sciences, 1994, 307 Suppl 1: S91-5.
[4] SHIOW-LIN PAN. Identification of Apoptotic and Antiangiogenic Activities of Terazosin in Human Prostate Cancer and Endothelial Cells[J]. Journal of Urology, 2003, 169 2: Pages 724-729. DOI:10.1016/s0022-5347(05)64002-5
[5] XINPING CHEN. Terazosin activates Pgk1 and Hsp90 to promote stress resistance[J]. Nature chemical biology, 2014, 11 1: 19-25. DOI:10.1038/nchembio.1657

Terazosin hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Terazosin
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Terazosin hydrochloride Suppliers

Canada 1 China 217 Europe 2 Germany 4 India 16 Israel 1 Slovakia 1 Switzerland 1 United Kingdom 9 United States 34 Global 286
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
BIOTREND Chemicals AG
Tel
--
Fax
--
Email
info@biotrend.ch
Country
Germany
ProdList
1250
Advantage
62
CU Chemie Uetikon GmbH
Tel
--
Fax
--
Email
info@uetikon.com
Country
Germany
ProdList
192
Advantage
69
Archimica
Tel
--
Fax
--
Email
juergen.brockmann@clariant.com
Country
Germany
ProdList
526
Advantage
68
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View Lastest Price from Terazosin hydrochloride manufacturers

Baoji Guokang Healthchem Co., Ltd.
Product
Terazosin hydrochloride 63074-08-8
Price
US $121.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200T
Release date
2021-06-04
Shandong Xuhuang New material CoLTD
Product
Terazosin Hydrochloride 63074-08-8
Price
US $80.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10T
Release date
2025-02-25
Zhuozhou Wenxi import and Export Co., Ltd
Product
Terazosin hydrochloride 63074-08-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

63074-08-8, Terazosin hydrochlorideRelated Search:

TERAZOSIN HYDROCHLORIDE DIHYDRATE Cetirizine dihydrochloride Telmisartan 4-Amino-6,7-dimethoxyquinazoline Terazosin Quinazoline Terazosin hydrochloride TERAZOSIN HYDROCHLORIDE DIHYDRATEIMP. O (EP): 1,4-BIS[(TETRAHYDROFURAN-2-YL)CARBONYL]PIPERAZINE TERAZOSIN HYDROCHLORIDE DIHYDRATEIMP. N (EP): 1-[[(2RS)-TETRAHYDROFURAN-2-YL]CARBONYL]PIPERAZINE TERAZOSIN HYDROCHLORIDE DIHYDRATEIMP. K (EP) AS HYDROCHLORIDE:PRAZOSIN HYDROCHLORIDE TERAZOSIN HYDROCHLORIDE MONOHYDRATE TERAZOSIN HYDROCHLORIDE DIHYDRATEIMP. M (EP): 1,4-BIS(FURAN-2-YLCARBONYL)PIPERAZINE (R)-(+)-TERAZOSIN HYDROCHLORIDE DIHYDRATE Terazosin hydrochloride, anhydrous TERAZOSIN HYDROCHLORIDE DIHYDRATEIMP. L (EP): 1-(FURAN-2-YLCARBONYL)-PIPERAZINE TERAZOSIN HYDROCHLORIDE DIHYDRATEIMP. C (EP): 6,7-DIMETHOXY-2-(PIPERAZIN-1-YL)QUINAZOLIN-4-AMINE TERAZOSIN HYDROCHLORIDE DIHYDRATEIMP. A (EP): 2-CHLORO-6,7-DIMETHOXYQUINAZOLIN-4-AMINE

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