Identification Description Regulatory Status Usage Natural occurrence Aroma
ChemicalBook > CAS DataBase List > 3-Acetylpyridine

3-Acetylpyridine

Identification Description Regulatory Status Usage Natural occurrence Aroma
Product Name
3-Acetylpyridine
CAS No.
350-03-8
Chemical Name
3-Acetylpyridine
Synonyms
3-Acetylpiridine;methylpyridylketone;1-(3-PYRIDINYL)ETHANONE;Ethanone,1-(3-pyridinyl)-;NSC 761;FEMA 3424;Imatinib-int A;3-ActylPyridine;3-ACETOPYRIDINE;3-ACETYLPYRIDNE
CBNumber
CB9286704
Molecular Formula
C7H7NO
Formula Weight
121.14
MOL File
350-03-8.mol
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3-Acetylpyridine Property

Melting point:
11-13 °C (lit.)
Boiling point:
220 °C (lit.)
Density 
1.102 g/mL at 25 °C (lit.)
vapor pressure 
0.3Pa at 20℃
FEMA 
3424 | 3-ACETYLPYRIDINE
refractive index 
n20/D 1.534(lit.)
Flash point:
302 °F
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Liquid
pka
pK1: 3.256(+1) (25°C)
Specific Gravity
1.102
color 
Clear colorless to yellow
PH
6.5-7.5 (H2O, 20℃)
Odor
at 1.00 % in dipropylene glycol. sweet nutty dry hawthorn phenolic woody popcorn
Odor Type
nutty
biological source
synthetic
Water Solubility 
SOLUBLE IN HOT WATER
Merck 
14,6116
JECFA Number
1316
BRN 
107751
InChIKey
WEGYGNROSJDEIW-UHFFFAOYSA-N
LogP
0.34 at 13℃
CAS DataBase Reference
350-03-8(CAS DataBase Reference)
NIST Chemistry Reference
Ethanone, 1-(3-pyridinyl)-(350-03-8)
EPA Substance Registry System
Ethanone, 1-(3-pyridinyl)- (350-03-8)
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Safety

Hazard Codes 
T,Xi,Xn
Risk Statements 
25-36/38-36/37/38-20/21/22
Safety Statements 
45-37/39-28A-26-36
RIDADR 
UN 2810 6.1/PG 3
WGK Germany 
3
RTECS 
OB5425000
F 
8-10
Hazard Note 
Irritant
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
II
HS Code 
29333999
Toxicity
LD50 orl-rat: 46 mg/kg JACTDZ 1,681,92
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
W342408
Product name
3-Acetylpyridine
Purity
≥98%, FG
Packaging
100g
Price
$116
Updated
2024/03/01
Sigma-Aldrich
Product number
W342408
Product name
3-Acetylpyridine
Purity
≥98%, FG
Packaging
1kg
Price
$472
Updated
2024/03/01
Sigma-Aldrich
Product number
W342408
Product name
3-Acetylpyridine
Purity
≥98%, FG
Packaging
5kg
Price
$1610
Updated
2024/03/01
Sigma-Aldrich
Product number
W342408
Product name
3-Acetylpyridine
Purity
≥98%, FG
Packaging
10Kg
Price
$3020
Updated
2024/03/01
Sigma-Aldrich
Product number
A21207
Product name
3-Acetylpyridine
Purity
98%
Packaging
100g
Price
$24.96
Updated
2024/03/01
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3-Acetylpyridine Chemical Properties,Usage,Production

Identification

CAS.No.: 
350-03-8 
FL.No.: 
14.039
FEMA.No.: 
3424
NAS.No.: 
3424
CoE.No.: 
2316
EINECS.No.: 
206-496-7 
JECFA.No.: 
1316
　
　

Description

A colorless liquid with sweet, nutty, popcorn-like aroma.

Regulatory Status

CoE: Used provisionally. Bev.: 2 ppm; Food: 3 ppm
FDA: n/a
FDA (other): n/a
JECFA: ADI: Acceptable. No safety concern at current levels of intake when used as a flavoring agent (2004).

Usage

Reported uses (ppm): (FEMA, 1994)

Food Category 
Usual 
Max. 
Baked goods 
2
3
Frozen dairy 
1
2
Gelatins,puddings 
1
2
Nonalcoholic beverages 
1
2
Soft candy 
2
3

Natural occurrence

Reported found in roasted filberts, beer, brandy, coffee, malt and wheaten bread.

Aroma

Powerful, almost choking, Cigar-tobaccotype odor, which becomes pleasant only at extreme dilution, then also more typical tobacco-like. In certain types of flower bases, substitutes for flower absolutes, etc. this chemical can produce interesting and desirable effects, Lily, Jasmin, Tuberose, etc. are types of floral fragrances that may benefit from this effect.

Chemical Properties

A colorless liquid with sweet, nutty, popcorn-like aroma

Chemical Properties

clear colorless to yellow liquid

Occurrence

Reported found in roasted filberts, beer, brandy, coffee, malt and wheaten bread.

Uses

3-Acetylpyridine used as an intermediate for the synthesis of risedronate sodium, inhibitor of bone resorption. It is also used in perfumery.

Uses

Used in the fragrance industry and as an intermediate in the synthesis of a number of clinical drugs, including Imatinib, Mesylate, Metyrapone, Telithromycin, and Ridogrel. An analog of nicotinamide that competes for incorporation into NAD. It has been used to chemically lesion the inferior olive nucleus, thereby eliminating climbing fibers within the cerebellar cortex.

Production Methods

Produced from Ethyl nicotinate and Ethyl acetoacetate, in principle by hydrolysis of Aceto acetylpyridine.

Definition

It is a nicotinic acidantagonist.

Preparation

Dry distillation of calcium nicotinate with calcium acetate.

Safety Profile

Poison by ingestion. Moderately toxic by intraperitoneal routeMutation data reported. A flammable liquid. When heated to decomposition emits toxic fumes of NOx,. See also KETONES

Purification Methods

It is purified by dissolving in HCl, extracting with Et2O to remove the possible impurity of nicotinic acid, basified with NaOH and extracted with Et2O. The dried extract is filtered, evaporated and the residual oil is distilled. If the NMR spectrum indicates further impurities, then convert it to the phenylhydrazone (m 137o, yellow needles from EtOH). This is hydrolysed with HCl [Engler & Kiby Chem Ber 22 597 1889], the phenylhydrazine HCl is removed by filtration, NaNO2 is added, the solution is basified with aqueous NaOH and extracted with Et2O as before and distilled at atmospheric pressure to give 3-acetylpyridine as a colourless oil. Purification can also be achieved by shaking with 50% aqueous KOH, extracting with Et2O, drying the extract and distilling it at atmospheric pressure or in vacuo. [Kloetzel & Chubb J Am Chem Soc 79 4226 1957.] The hydrochloride has m 180-181o (from MeOH/EtOH), the picrate has m 133.8-134.8o (from H2O), and the phenylhydrazone has m 137o (129-130o)(needles, from EtOH) [Webb & Webb J Am Chem Soc 71 2285 1949]. The ketoxime has m 112o (from EtOH or *C6H6). [Strong & McElvain J Am Chem Soc 55 816 1933, Kolloff & Hunter J Am Chem Soc 63 490 1941, Beilstein 21/7 V 394.]

3-Acetylpyridine Preparation Products And Raw materials

Raw materials

Nicotinic acid Calcium acetate

Preparation Products

5-(Pyridin-3-yl)-1H-pyrazole-3-carboxamide ,97% 3-ACETYL-2-CHLOROPYRIDINE 5-PYRIDIN-3-YL-1H-PYRAZOLE-3-CARBOXYLIC ACID 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one ETHYL 3-PYRIDYLACETATE 3-(2-Bromoacetyl)pyridine hydrobromide 5-(PYRIDIN-3-YL)-1H-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER 4-(Pyridin-3-yl)pyrimidin-2-amine 5-(Pyridin-3-yl)-1H-pyrazole-3-carbohydrazide ,97% 2-Amino-3-acetylpyridine
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View Lastest Price from 3-Acetylpyridine manufacturers

hebei hongtan Biotechnology Co., Ltd
Product
3-Acetylpyridine 350-03-8
Price
US $30.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000kg
Release date
2024-05-13
Hebei Weibang Biotechnology Co., Ltd
Product
3-Acetylpyridine 350-03-8
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100 mt
Release date
2024-11-07
Hebei Chuanghai Biotechnology Co,.LTD
Product
3-Acetylpyridine 350-03-8
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2024-08-22

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