5-Indolylboronic acid

5-Indolylboronic acid Property

Melting point:

170-175 °C

Boiling point:

433.2±37.0 °C(Predicted)

Density 

1.33±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

pka

8.91±0.30(Predicted)

form 

Crystalline Powder

color 

White

Sensitive 

Air Sensitive

CAS DataBase Reference

144104-59-6(CAS DataBase Reference)

Safety

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-21/22

Safety Statements 

26-36/37/39

WGK Germany 

3

Hazard Note 

Irritant/Keep Cold

HazardClass 

IRRITANT, KEEP COLD

HS Code 

29339900

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

5-Indolylboronic acid Chemical Properties,Usage,Production

Chemical Properties

White to light yellow crystal powde

Uses

Indole-5-boronic acid is a useful reagent for palladium and copper catalyzed oxidative cross-coupling of mercaptoacetylenes and arylboronic acids. A reagent used in the synthesis of other biologically active molecules.

Uses

Reactant involved in the synthesis of biologically active molecules including:

• Indole inhibitors of MMP-13 for arthritic disease treatment
• Substituted pyrimidines acting as tubulin polymerization inhibitors

• Aryl- hetarylfurocoumarins
• Aryl-substituted oxabenzindoles and methanobenzindoles

• Oxidative cross-coupling with mercaptoacetylenes
• Trifluoromethylation

General Description

May contain varying amounts of anhydride

Synthesis

General procedure for the synthesis of 5-bromoindole and triisopropyl borate as raw materials for the synthesis of 5-bromoindoleboronic acid: In a dry and nitrogen-protected three-necked flask, anhydrous THF (80 mL) solution of NaH (1.02 g, 42.5 mmol) was added, equipped with a magnetic stirrer and a septum. The reaction system was cooled to 0 °C under N2 atmosphere and 5-bromoindole (5.0 g, 25.5 mmol) was added slowly dropwise, and stirring was continued for 15 min after completion of the dropwise addition. Subsequently, n-BuLi (2.5 M hexane solution, 15 mL, 37.5 mmol) was added slowly and stirred for 10 min. Then, triisopropyl borate (22 mL, 51 mmol) was added dropwise. After completion of the dropwise addition, the reaction mixture was gradually warmed to room temperature and stirred overnight, and stirring was continued for 2 hours. After completion of the reaction, the reaction was quenched with saturated NH4Cl solution and stirred for 30 minutes. The organic layer was separated and the aqueous layer was extracted with EtOAc. The organic layers were combined, washed sequentially with water and brine and dried over Na2SO4. After complete removal of the solvent, the residue was treated with EtOAc/petroleum ether and filtered to afford the target product 1H-indol-5-ylboronic acid (b1) as a colorless solid (1.02 g, 25% yield). The structure of the product was determined by 1H-NMR (DMSO-d6) δ 11.1 (s, 1H), 8.30 (s, 1H), 7.81 (d, 1H, J = 8.1 Hz), 7.47 (d, 1H, J = 8.1 Hz), 7.34 (s, 1H) and 13C-NMR (100 MHz, DMSO-d6) δ 138.0, 128.0, 127.5, 127.4, 127.3, 125.4, 111.0, 102.0 confirmed.

References

[1] Tetrahedron Letters, 2017, vol. 58, # 1, p. 35 - 42