2-Methylcinnamic acid
- Product Name
- 2-Methylcinnamic acid
- CAS No.
- 2373-76-4
- Chemical Name
- 2-Methylcinnamic acid
- Synonyms
- 5-Bromovaniline;2-Methylciamic acid;RARECHEM BK HC T303;TIMTEC-BB SBB003946;2-Methylcinnamicaci;2-METHYLCINNAMIC ACID;o-Methylcinnamic acid;SPECS AI-942/25034752;METHYLCINNAMIC ACID,2-;3-O-TOLYL-ACRYLIC ACID
- CBNumber
- CB9297335
- Molecular Formula
- C10H10O2
- Formula Weight
- 162.19
- MOL File
- 2373-76-4.mol
2-Methylcinnamic acid Property
- Melting point:
- 174-176 °C(lit.)
- Boiling point:
- 228.88°C (rough estimate)
- Density
- 1.0281 (rough estimate)
- refractive index
- 1.5766 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- almost transparency in Methanol
- form
- powder to crystal
- pka
- 4.5(at 25℃)
- color
- White to Almost white
- BRN
- 2500607
- LogP
- 2.870 (est)
- CAS DataBase Reference
- 2373-76-4(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 37/39-26-36-24/25
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29163990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 433101
- Product name
- 2-Methylcinnamic acid, predominantly trans
- Purity
- 99%
- Packaging
- 5g
- Price
- $29.6
- Updated
- 2025/07/31
- Product number
- M1295
- Product name
- 2-Methylcinnamic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $76
- Updated
- 2025/07/31
- Product number
- M1295
- Product name
- 2-Methylcinnamic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $187
- Updated
- 2025/07/31
- Product number
- M304958
- Product name
- 2-Methylcinnamic Acid
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- I238
- Product name
- 2-Methylcinnamic acid, predominantly trans
- Packaging
- 100g
- Price
- $188
- Updated
- 2021/12/16
2-Methylcinnamic acid Chemical Properties,Usage,Production
Chemical Properties
White flakes or crystal
Uses
2-Methylcinnamic acid may be used as starting reagent for the total synthesis of the cytotoxic alkaloid, 22-hydroxyacuminatine and for the preparation of (E)-2-methylcinnamic acid i-butylammonium salt.
Definition
ChEBI: 2-Methylcinnamic Acid is a member of cinnamic acids.
General Description
2-Methylcinnamic acid has been reported to exhibit strong anti-fungal activity against white-rot fungus Lenzites betulina and brown-rot fungus Laetiporus sulphureus. Hydrogenation of 2-methylcinnamic acid using Walphos ligands and their biferrocene analogs has been studied.
Synthesis
141-82-2
529-20-4
939-57-1
GENERAL STEPS: 2-Methylbenzaldehyde (50 g, 417 mmol) was dissolved in pyridine (2 eq., 65 mL) under stirring conditions, followed by the addition of malonic acid (86.6 g, 834 mmol). The reaction mixture was heated to reflux for 4-5 hours. Upon completion of the reaction, the mixture was slowly poured into ice water and then acidified with 1N HCl. The precipitated white solid was collected by filtration, washed with water and dried under high vacuum for 3-4 h to give (E)-3-(o-tolyl)acrylic acid (57 g, 87% yield).
References
[1] Patent: US2013/178457, 2013, A1. Location in patent: Paragraph 0173
[2] Patent: WO2013/5168, 2013, A2. Location in patent: Page/Page column 32
[3] Tetrahedron Letters, 2011, vol. 52, # 41, p. 5371 - 5374
[4] Journal of Organic Chemistry, 1986, vol. 51, # 7, p. 1120 - 1123
[5] Patent: WO2013/74892, 2013, A1. Location in patent: Page/Page column 39-40
2-Methylcinnamic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Methylcinnamic acid manufacturers
- Product
- 2-Methylcinnamic Acid 2373-76-4
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99.8%
- Supply Ability
- 100tons
- Release date
- 2024-08-20
- Product
- 2-Methylcinnamic acid 2373-76-4
- Price
- US $34.00-1.10/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-25
- Product
- 2-Methylcinnamic acid 2373-76-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%-99.9%
- Supply Ability
- 100kg
- Release date
- 2020-01-10