ChemicalBook > CAS DataBase List > 5-Bromo-1-benzofuran

5-Bromo-1-benzofuran

Product Name
5-Bromo-1-benzofuran
CAS No.
23145-07-5
Chemical Name
5-Bromo-1-benzofuran
Synonyms
5-BROMOBENZOFURAN;5-Brombenzofuran;BUTTPARK 95\50-66;5-Bromobenzo[b]furan;5-BROMO-1-BENZOFURAN;Benzofuran, 5-broMo-;5-Bromobenzofuran ,97%;5-BROMOBENZO[BETA]FURAN;5-Bromobenzo[beta]furan, 98 %
CBNumber
CB9297481
Molecular Formula
C8H5BrO
Formula Weight
197.03
MOL File
23145-07-5.mol
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5-Bromo-1-benzofuran Property

Melting point:
8°C(lit.)
Boiling point:
226°C(lit.)
Density 
1.573 g/mL at 25 °C
refractive index 
n20/D1.605
storage temp. 
Sealed in dry,Room Temperature
form 
liquid
color 
Colourless to light yellow
InChI
InChI=1S/C8H5BrO/c9-7-1-2-8-6(5-7)3-4-10-8/h1-5H
InChIKey
AYOVPQORFBWFNO-UHFFFAOYSA-N
SMILES
O1C2=CC=C(Br)C=C2C=C1
CAS DataBase Reference
23145-07-5(CAS DataBase Reference)
EPA Substance Registry System
Benzofuran, 5-bromo- (23145-07-5)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-22
Safety Statements 
26-37/39
WGK Germany 
3
Hazard Note 
Irritant
HS Code 
29329990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H351Suspected of causing cancer

Precautionary statements

P201Obtain special instructions before use.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
761796
Product name
5-Bromobenzofuran
Purity
97%
Packaging
1g
Price
$100.1
Updated
2025/07/31
TCI Chemical
Product number
B3889
Product name
5-Bromobenzofuran
Purity
>97.0%(GC)
Packaging
1g
Price
$50
Updated
2025/07/31
TCI Chemical
Product number
B3889
Product name
5-Bromobenzofuran
Purity
>97.0%(GC)
Packaging
5g
Price
$149
Updated
2025/07/31
TRC
Product number
B680355
Product name
5-Bromobenzofuran
Packaging
5g
Price
$195
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB153766
Product name
5-Bromo-1-benzofuran
Packaging
10g
Price
$275
Updated
2021/12/16
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5-Bromo-1-benzofuran Chemical Properties,Usage,Production

Chemical Properties

Light yellow liquid

Uses

5-Bromobenzofuran is used in the synthesis of 1-(7-benzofuranyl)-4-methylpiperazine; a compound shown to bind strongly and with high selectivity to the serotonin receptor 5-HT2A in the presence of the receptor 5-HT7 in vitro.

Synthesis

112598-18-2

23145-07-5

The general procedure for the synthesis of 5-bromobenzofuran from 4-bromophenoxyacetaldehyde diethyl acetal was as follows: polyphosphoric acid (10 g) was added to a solution of benzene (50 mL), the product of step A (8.4 g). The reaction mixture was heated to reflux for 4 hours. Upon completion of the reaction, the mixture was cooled to 0 °C and slowly poured into ice water (80 mL). The aqueous phase was extracted with ether and the organic phases were combined. The ether layer was washed sequentially with saturated sodium bicarbonate solution and brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 4.9 g of crude product in 85% yield.

References

[1] Patent: WO2004/33440, 2004, A1. Location in patent: Page 239-240
[2] Patent: US2004/147559, 2004, A1. Location in patent: Page 122
[3] Patent: US2004/106794, 2004, A1. Location in patent: Page 123
[4] Patent: WO2005/66147, 2005, A1. Location in patent: Page/Page column 209
[5] Patent: WO2005/68460, 2005, A1. Location in patent: Page/Page column 203

5-Bromo-1-benzofuran Preparation Products And Raw materials

Raw materials

Sodium hydride N,N-Dimethylformamide Sodium chloride Bromoacetaldehyde diethyl acetal Polyphosphoric acid Diethyl ether Benzene 4-Bromophenol Ethyl acetate Sodium bicarbonate Sodium hydroxide Magnesium sulfate PETROLEUM ETHER

Preparation Products

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View Lastest Price from 5-Bromo-1-benzofuran manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
5-Bromo-1-benzofuran 23145-07-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-10-09
Shaanxi Dideu New Materials Co. Ltd
Product
5-Bromo-1-benzofuran 23145-07-5
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-02-24
Shaanxi Dideu Medichem Co. Ltd
Product
5-Bromo-1-benzofuran 23145-07-5
Price
US $0.00-0.00/KG
Min. Order
1g
Purity
99%
Supply Ability
2000tons
Release date
2019-12-31

23145-07-5, 5-Bromo-1-benzofuranRelated Search:

Benzofuran Furan 1,2-Dibromobenzene 4'-Bromopropiophenone 3-Bromoanisole 4-Bromofluorobenzene 2-Bromobenzonitrile 1,3-Dibromobenzene 5-BROMO-1-BENZOFURAN-2-CARBOXYLIC ACID Bromine 1-(5-BROMO-1-BENZOFURAN-2-YL)ETHANONE 3,5-DIBROMOBENZO[B]FURAN 6-CHLORO-BENZOFURAN-3-ONE 7-BROMO-1-BENZOFURAN-2-CARBOXYLICACID METHYL-7-BROMO-1-BENZOFURAN-2-CARBOXYLATE ethyl 2-(5-bromobenzofuran-3-yl)acetate 4-Fluoro-7-bromobenzofuran 5-BROMOBENZO[B]FURAN-2-CARBONYL CHLORIDE

  • 5-BROMO-1-BENZOFURAN
  • 5-BROMOBENZO[BETA]FURAN
  • 5-BROMOBENZOFURAN
  • BUTTPARK 95\50-66
  • 5-Bromobenzo[b]furan
  • 5-Bromobenzo[beta]furan, 98 %
  • 5-Bromobenzofuran ,97%
  • Benzofuran, 5-broMo-
  • 5-Brombenzofuran
  • 23145-07-5
  • C8H5BrO
  • pharmacetical