Pyridoxamine dihydrochloride

ChemicalBook > CAS DataBase List > Pyridoxamine dihydrochloride

Pyridoxamine dihydrochloride

Product Name: Pyridoxamine dihydrochloride
CAS No.: 524-36-7
Chemical Name: Pyridoxamine dihydrochloride
Synonyms: PYRIDOXAMINE;PYRIDOXAMINE HCL;NSC 21278;dihydrochL;82885_FLUKA;P9158_SIGMA;P9380_SIGMA;287091_ALDRICH;PyridoxaMine 2HC1;PYRIDOXAMINE 2HCL
CBNumber: CB9297759
Molecular Formula: C8H14Cl2N2O2
Formula Weight: 241.11
MOL File: 524-36-7.mol

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Pyridoxamine dihydrochloride Property

Melting point:: 224-226 °C (dec.)(lit.)
Density: 1.4025 (rough estimate)
refractive index: 1.6100 (estimate)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form: Powder or Solid
pka: pKa 3.31(H2O t = 25 I = 0.1)(Approximate)
color: White to off-white to pale brown
Water Solubility: Soluble in DMSO, water, or methanol /n
Merck: 7980
BRN: 3632748
CAS DataBase Reference: 524-36-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 2
RTECS: UV1230000
HazardClass: IRRITANT
HS Code: 29333990
Toxicity: cat,LD50,intravenous,540mg/kg (540mg/kg),GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDSBEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLDGASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA",Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P9380
Product name: Pyridoxamine dihydrochloride
Purity: analytical standard, ≥98%
Packaging: 1g
Price: $91
Updated: 2024/03/01

Sigma-Aldrich

Product number: P9158
Product name: Pyridoxamine dihydrochloride
Purity: BioReagent, suitable for cell culture
Packaging: 1g
Price: $125
Updated: 2024/03/01

Sigma-Aldrich

Product number: 545068
Product name: Pyridoxamine, Dihydrochloride - CAS 524-36-7 - Calbiochem
Packaging: 5G
Price: $289
Updated: 2024/03/01

TCI Chemical

Product number: P2688
Product name: Pyridoxamine Dihydrochloride
Packaging: 1G
Price: $36
Updated: 2024/03/01

TCI Chemical

Product number: P2688
Product name: Pyridoxamine Dihydrochloride
Packaging: 25G
Price: $285
Updated: 2024/03/01

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Pyridoxamine dihydrochloride Chemical Properties,Usage,Production

Description

Pyridoxamine dihydrochloride is a salt and amine form of pyridoxamine, which belongs to the family of vitamin B6 compounds. Pyridoxamine occurs naturally in animal-based food products. Its deficiency in humans potentially causes sideroblastic anemia, weakness, insomnia, and neurological disorders. It has been reported to be effective against diabetic nephropathy. Pyridoxamine dihydrochloride acts as a catalyst in the metabolism of fats, carbohydrates, and proteins in the body, thereby assisting in maintaining energy balance in kidney disease patients.

Chemical Properties

It is a white to yellowish crystal or crystalline powder that readily absorbs moisture. It is generally stable at room temperature but tends to change color when exposed to light. Its melting point is at 226-227℃, with decomposition. It exhibits maximum absorption at a wavelength of 287.5nm. The substance is soluble in water, slightly soluble in ethanol, but insoluble in ether or chloroform.

Uses

Pyridoxamine dihydrochloride (Pyridorin, NephroGenex, 524-36-7) inhibits formation of advanced glycation end products and scavenges reactive oxygen species and toxic carbonyls. Whether these effects translate into kidney protection is unknown, although a year-long study of the effects of pyridoxamine dihydrochlo-ride in patients with type 2 diabetes and proteinuria failed to show a difference in kidney function decline with pyri-doxamine dihydrochloride in daily doses of 300 or 600 mg versus placebo treatment.

Preparation

The procedure for preparing pyridoxamine dihydrochloride involves several steps: firstly enabling pyridoxal oxime to react with acetic acid and zinc to obtain acetic acid solution containing pyridoxamine, then decompressing the solution and reclaiming the acetic acid to obtain slurry concentrate, decompressing and reclaiming the acetic acid again to obtain pyridoxamine water solution, regulating the pH value to be alkaline so as to separate pyridoxamine out, adding water and hydrochloric acid after vacuum filteration, decoloring and filtering to obtain filtrate, decompressing and concentrating the filtrate until white solids are separated out, adding solvent and stirring, and finally crystallizing at the lower temperature, filtering and drying to obtain the pyridoxamine dihydrochloride.
CN101628892A

Definition

ChEBI: Pyridoxamine dihydrochloride is a hydrochloride obtained by combining pyridoxamine with two molar equivalents of hydrochloric acid. Used for treatment of diabetic nephropathy. It has a role as an Escherichia coli metabolite, a Saccharomyces cerevisiae metabolite, a human metabolite, a mouse metabolite, a plant metabolite, an iron chelator and a nephroprotective agent. It is a hydrochloride and a vitamin B6. It contains a pyridoxamine(2+).

Pharmacokinetics

The progression of diabetic nephropathy can be blocked by Pyridoxamine dihydrochloride, a derivative of vitamin B6, which is a potent inhibitor of AGE formation. However, it has been observed that this treatment is only effective in patients who have relatively preserved kidney function (baseline SCr 1.3 to 1.9 mg/dL).

Purification Methods

The amine salt is crystallised from hot MeOH. The free base crystallises from EtOH with m 193-193.5o [Harris et al. J Biol Chem 154 315 1944, J Am Chem Soc 66 2088 1944]. [Beilstein 22 IV 6064, 22/12 V 324.]

Pyridoxamine dihydrochloride Preparation Products And Raw materials

Raw materials

Manganese dioxide Pyridoxine hydrochloride

Preparation Products

Pyridoxal phosphate

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View Lastest Price from Pyridoxamine dihydrochloride manufacturers

Ouhuang Engineering Materials (Hubei) Co., Ltd

Product: Pyridoxamine dihydrochloride 524-36-7
Price: US $15.00/kg
Min. Order: 1kg
Purity: 99.912%
Supply Ability: 10ton
Release date: 2024-04-22

Hebei Duling International Trade Co. LTD

Product: Pyridoxamine dihydrochloride 524-36-7
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000 Ton
Release date: 2023-01-11

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Pyridoxamine dihydrochloride 524-36-7
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-01-16

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524-36-7

C8H12N2O22HClH2O

C8H12N2O22HClC8H14Cl2N2O2