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Tetrabenzyl pyrophosphate

Product Name
Tetrabenzyl pyrophosphate
CAS No.
990-91-0
Chemical Name
Tetrabenzyl pyrophosphate
Synonyms
PYROPHOSPHORIC ACID TETRABENZYL ESTER;TETRABENZYL DIPHOSPHATE;C2gH2gO7P2;TetrabenzyL;Bis(phenylmethox;Benzyl Pyrophosphate;Tetracyl pyrophosphate;Tetrabenzyl yrophosphate;Fosaprepitant Impurity S;Tetrabenzyl Pyrophosphte
CBNumber
CB9300303
Molecular Formula
C28H28O7P2
Formula Weight
538.47
MOL File
990-91-0.mol
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Tetrabenzyl pyrophosphate Property

Melting point:
63-66 °C (lit.)
Boiling point:
601.6±55.0 °C(Predicted)
Density 
1.289±0.06 g/cm3(Predicted)
vapor pressure 
0.001Pa at 140℃
storage temp. 
-20°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Powder or Crystalline Powder
color 
White to off-white
Water Solubility 
Slightly soluble in water.
Sensitive 
Moisture Sensitive
BRN 
2068292
InChI
InChI=1S/C28H28O7P2/c29-36(31-21-25-13-5-1-6-14-25,32-22-26-15-7-2-8-16-26)35-37(30,33-23-27-17-9-3-10-18-27)34-24-28-19-11-4-12-20-28/h1-20H,21-24H2
InChIKey
NSBNXCZCLRBQTA-UHFFFAOYSA-N
SMILES
P(=O)(OCC1C=CC=CC=1)(OCC1C=CC=CC=1)OP(=O)(OCC1C=CC=CC=1)OCC1C=CC=CC=1
CAS DataBase Reference
990-91-0(CAS DataBase Reference)
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Safety

Hazard Codes 
C
Risk Statements 
34
Safety Statements 
26-36/37/39-45
RIDADR 
UN 3261 8/PG 2
WGK Germany 
3
F 
10-21
HazardClass 
8
PackingGroup 
II
HS Code 
29209090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
418633
Product name
Tetrabenzyl pyrophosphate
Purity
98%
Packaging
1g
Price
$323
Updated
2024/03/01
TCI Chemical
Product number
P1223
Product name
Tetrabenzyl Pyrophosphate
Purity
>98.0%(HPLC)
Packaging
1g
Price
$70
Updated
2024/03/01
Alfa Aesar
Product number
L09083
Product name
Tetrabenzyl pyrophosphate, 98%
Packaging
1g
Price
$217
Updated
2024/03/01
Alfa Aesar
Product number
L09083
Product name
Tetrabenzyl pyrophosphate, 98%
Packaging
5g
Price
$801
Updated
2024/03/01
Alfa Aesar
Product number
L09083
Product name
Tetrabenzyl pyrophosphate, 98%
Packaging
250mg
Price
$64.8
Updated
2021/12/16
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Tetrabenzyl pyrophosphate Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Tetrabenzyl pyrophosphate is used in the preparation of phosphoryl derivatives of shikimic acid in the presence of LDA. It is used in the preparation of dibenzyl phosphoro fluoridate in the presence of cesium fluoride as a catalyst. It is also used as a precursor in pharmaceuticals and involved in the phosphorylation of inositol derivatives.

Uses

Phosphorylating reagent.

Preparation

The production of tetrabenzyl pyrophosphate by the action of acyl chlorides on dibenzyl hydrogen phosphate, and a novel reaction of tetraphenyl pyrophosphate.
Preparation of Tetrabenzyl Pyrophosphate: A flask fitted with a nitrogen inlet, overhead stirrer, teflon-coated thermocouple probe, and pressure-equalizing addition funnel was charged with 350 milliliters of dry (water content ≦50 μg/mL), peroxide-free tetrahydrofuran, followed by 50.0 grams (174 millimoles) of dibenzylphosphoric acid (DBP), and the resulting mixture was stirred until the solid dissolved (about 10-15 minutes). A solution of 18.9 grams (91.6 millimoles) of dicyclohexylcarbodiimide (DCC) in 215 milliliters of THF was added from the addition funnel to a stirred, cooled (water-bath) solution of DBP at a rate to maintain the temperature at about 20°-25° C. The reaction is slightly exothermic and the addition took about 30 minutes. Within minutes, a precipitate of dicyclohexylurea formed in the mixture. Stirring was continued for about 2 hours at 20°-25° C. The reaction was monitored by HPLC assay using VYDAC C-18 (300A, 4.6×250 mm) column with water (0.02M KH2PO4) acetonitrile as eluent. The reaction was complete in about 1 hour (assay showing <2 percent unreacted DBP). The mixture was then filtered while excluding moisture to remove dicyclohexylurea. The filter cake was washed with two 25 milliliter portions of THF. The solution when assayed by HPLC showed 45.9 grams (98 percent) yield of tetrabenzyl pyrophosphate (TBPP) in 620 milliliters of THF (0.137M). The filtrate was then stored at 0° C. with exclusion of moisture until the next step.

Tetrabenzyl pyrophosphate Preparation Products And Raw materials

Raw materials

Heptane Dibenzyl phosphate Isopropyl acetate Dicyclohexylcarbodiimide

Preparation Products

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View Lastest Price from Tetrabenzyl pyrophosphate manufacturers

Hebei Mojin Biotechnology Co., Ltd
Product
TETRABENZYL DIPHOSPHATE 990-91-0
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-01
Hebei Guanlang Biotechnology Co,.LTD
Product
Tetrabenzyl Pyrophosphate 990-91-0
Price
US $11.00/Kg/Bag
Min. Order
1g
Purity
99%
Supply Ability
10000kg
Release date
2021-07-02
Hebei Guanlang Biotechnology Co., Ltd.
Product
TETRABENZYL DIPHOSPHATE 990-91-0
Price
US $1.00/PCS
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2021-05-17

990-91-0, Tetrabenzyl pyrophosphateRelated Search:

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  • PYROPHOSPHORIC ACID TETRABENZYL ESTER
  • TETRABENZYL PYROPHOSPHATE
  • TETRABENZYL DIPHOSPHATE
  • Tetrabenzyl pyrophosphate, tech.
  • Pyrophosphoric acid tetrabenzyl ester, Tetrabenzyl diphosphate
  • Bis(phenylmethoxy)phosphoryl bis(phenylmethyl) phosphate
  • Benzyl Pyrophosphate
  • Diphosphoric Acid P,P,P',P'-Tetrakis(phenylMethyl) Ester
  • Tetrabenzyl yrophosphate
  • Bis(phenylmethox
  • Tetrabenzyl pyrophosphate Pyrophosphoric acid tetrabenzyl ester
  • Tetrabenzyl pyrophosphate 98%
  • dibenzyl {[bis(benzyloxy)phosphoryl]oxy}phosphonate
  • yrophosphoric acid tetrabenzyl ester
  • TetrabenzylPyrophosphate&gt
  • Tetrabenzyl pyrophosphate, 99%, for synthesis
  • TetrabenzyL
  • Tetrabenzylpyrophosphate (TBPP)
  • TETRABENZYL PYROPHOSPHATE 990-91-0
  • Creatine Phosphate Impurity 21（Tetrabenzyl Diphosphate）
  • Fosaprepitant Impurity S
  • Tetrabenzyl Pyrpophosphate
  • dibenzyl bis(phenylmethoxy)phosphoryl phosphate
  • Tetracyl pyrophosphate
  • P,P,P',P'-Tetrakis(phenylmethyl) (diphosphate)
  • Tetrabenzyl Pyrophosphte
  • C2gH2gO7P2
  • 990-91-0
  • C28H28O7P2
  • C6H5CH2O2POOPOOCH2C6H52
  • Building Blocks
  • Organic Phosphates/Phosphites
  • Phosphorus Compounds
  • Organic Building Blocks
  • DNA / RNA Synthesis
  • Phosphorylation
  • Phosphorylating Agents
  • Phosphorylating and Phosphitylating Agents
  • Biochemistry
  • Nucleosides, Nucleotides & Related Reagents
  • Phosphorylating and Phosphorothioating Agents
  • Phosphorylation
  • Protecting Agents, Phosphorylating Agents & Condensing Agents
  • Synthetic Organic Chemistry