ChemicalBook > CAS DataBase List > LMI070

LMI070

Product Name: LMI070
CAS No.: 1562338-42-4
Chemical Name: LMI070
Synonyms: Branaplam;LMI070;NVS-SM1;LMI070 (NVS-SM1);NVS-SM1; LMI-070;;Branaplam (LMI070);NVS-SM1, Branaplam;LMI070 (Branaplam);LMI 070;LMI-070;LMI070;Branaplam, 10 mM in DMSO
CBNumber: CB93053903
Molecular Formula: C22H27N5O2
Formula Weight: 393.48
MOL File: 1562338-42-4.mol

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LMI070 Property

Boiling point:: 660.0±55.0 °C(Predicted)
Density: 1.171±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:3.0(Max Conc. mg/mL);7.62(Max Conc. mM)
form: A crystalline solid
pka: 7.84±0.40(Predicted)
color: White to yellow
InChI: InChI=1S/C22H27N5O2/c1-21(2)10-16(11-22(3,4)27-21)29-20-8-7-18(25-26-20)17-6-5-14(9-19(17)28)15-12-23-24-13-15/h5-9,12-13,16,27-28H,10-11H2,1-4H3,(H,23,24)
InChIKey: STWTUEAWRAIWJG-UHFFFAOYSA-N
SMILES: C1(O)=CC(C2=CNN=C2)=CC=C1C1=NN=C(OC2CC(C)(C)NC(C)(C)C2)C=C1

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 26757
Product name: LMI070
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 26757
Product name: LMI070
Packaging: 25mg
Price: $796
Updated: 2024/03/01

Cayman Chemical

Product number: 26757
Product name: LMI070
Packaging: 5mg
Price: $202
Updated: 2024/03/01

Cayman Chemical

Product number: 26757
Product name: LMI070
Packaging: 10mg
Price: $363
Updated: 2024/03/01

ChemScene

Product number: CS-5319
Product name: Branaplam
Purity: 99.67%
Packaging: 50mg
Price: $490
Updated: 2021/12/16

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LMI070 Chemical Properties,Usage,Production

Uses

Branaplam (LMI070; NVS-SM1) is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC50 of 20 nM for SMN. Branaplam inhibits human-ether-a-go-go-related gene (hERG) with an IC50 of 6.3 μM. Branaplam elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model[1][2].

in vivo

Branaplam (LMI070; NVS-SM1; 3, 10, 30 mg/kg; oral) produces dose-dependent elevations of SMN2-FL transcript and SMN protein in brain and spinal cord^[1].
? Branaplam (1 mg/kg of IV; 3 mg/kg of PO) has a CL of 25 mL/min/kg and an AUC of 3.03 μM?h^[2].
? A single Branaplam (oral; 30 mg/kg) results in significant and durable SMN protein elevation in brain for up to 160 hours in C/+ mice^[1].
? Branaplam (oral; 0.03, 0.1, 0.3, 1, 3 mg/kg) improves body weight and extendes lifespan in n SMNΔ7 mice^[1].

Animal Model:	C/+ SMA mouse model^[1]
Dosage:	3, 10, 30 mg/kg
Administration:	Oral
Result:	Produced dose-dependent elevations of SMN2-FL transcript and SMN protein in brain and spinal cord.

Animal Model:	Male Sprague-Dawley rat^[2]
Dosage:	1 mg/kg (IV);3 mg/kg (PO) (Pharmacokinetic Analysis)
Administration:	IV or PO
Result:	Had a CL of 25 mL/min/kg and an AUC of 3.03 μM?h.

References

[1] Palacino J, et al. SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice. Nat Chem Biol. 2015 Jul;11(7):511-517. DOI:10.1038/nchembio.1837
[2] Cheung AK, et al. Discovery of Small Molecule Splicing Modulators of Survival Motor Neuron-2 (SMN2) for the Treatment of Spinal Muscular Atrophy (SMA). J Med Chem. 2018 Dec 27;61(24):11021-11036. DOI:10.1021/acs.jmedchem.8b01291

LMI070 Preparation Products And Raw materials

Raw materials

Preparation Products

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LMI070 Suppliers

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1562338-42-4, LMI070Related Search:

Infigratinib N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine NVS-PAK1-1 NVP-BSK805 NVP BGJ398 phosphate 3-amino-N-(3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl)-6-(3-(trifluoromethyl)pyridin-2-yl)pyrazine-2-carboxamide NVP-CGM097

NVS-SM1, Branaplam

LMI070

NVS-SM1

NVS-SM1; LMI-070;

LMI070 (Branaplam)

Branaplam

LMI070 (NVS-SM1)

5-(1H-pyrazol-4-yl)-2-(6-((2,2,6,6-tetramethylpiperidin-4-yl)oxy)pyridazin-3-yl)phenol

LMI 070;LMI-070;LMI070

Phenol, 5-(1H-pyrazol-4-yl)-2-[6-[(2,2,6,6-tetramethyl-4-piperidinyl)oxy]-3-pyridazinyl]-

Branaplam (LMI070)

SMN2,SMA,inhibit,SMN,DNA/RNA Synthesis,Inhibitor,hERG,atrophy,Potassium Channel,neuron-2,motor,KcsA,gene,orally,LMI070,splicing,LMI-070,spinal,survival,Branaplam,muscular

Branaplam, 10 mM in DMSO

1562338-42-4