Mal-PEG1-acid
- Product Name
- Mal-PEG1-acid
- CAS No.
- 760952-64-5
- Chemical Name
- Mal-PEG1-acid
- Synonyms
- Mal-PEG1-acid;Mal-PEG1-CH2CH2COOH;3-[2-(2,5-dioxopyrrol-1-yl)ethoxy]propanoic acid;3-[2-(2,5-Dioxo-2,5-dihydro-1-pyrrolyl)ethoxy]propanoic Acid;3-[2-(2,5-Dioxo-2,5-dihydro-1h-pyrrol-1-yl)ethoxy]propanoic acid;Propanoic acid, 3-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]-;Mal-PEG1-CH2CH2COOH/Propanoic acid, 3-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]-
- CBNumber
- CB93062525
- Molecular Formula
- C9H11NO5
- Formula Weight
- 213.19
- MOL File
- 760952-64-5.mol
Mal-PEG1-acid Property
- Boiling point:
- 419.4±30.0 °C(Predicted)
- Density
- 1.383±0.06 g/cm3(Predicted)
- storage temp.
- -20°C, protect from light
- pka
- 4.27±0.10(Predicted)
- form
- Solid
- color
- White to off-white
- InChI
- InChI=1S/C9H11NO5/c11-7-1-2-8(12)10(7)4-6-15-5-3-9(13)14/h1-2H,3-6H2,(H,13,14)
- InChIKey
- YTZFUAXOTCJZHP-UHFFFAOYSA-N
- SMILES
- C(O)(=O)CCOCCN1C(=O)C=CC1=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M158213
- Product name
- Mal-PEG1-acid
- Packaging
- 50mg
- Price
- $330
- Updated
- 2021/12/16
- Product number
- CS-0108926
- Product name
- Mal-PEG1-acid
- Packaging
- 250mg
- Price
- $520
- Updated
- 2021/12/16
- Product number
- BP-21859
- Product name
- Mal-PEG1-acid
- Purity
- 98%
- Packaging
- 250mg
- Price
- $575
- Updated
- 2021/12/16
- Product number
- BIPG1491
- Product name
- Mal-PEG1-acid
- Packaging
- 100mg
- Price
- $669
- Updated
- 2021/12/16
- Product number
- CS-0108926
- Product name
- Mal-PEG1-acid
- Packaging
- 100mg
- Price
- $300
- Updated
- 2021/12/16
Mal-PEG1-acid Chemical Properties,Usage,Production
Description
Mal-PEG1-acid is a PEG linker containing a maleimide group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Biological Activity
Mal-PEG1-acid is a non-cleavable ADC linker containing 1 unit PEG, which can be used to synthesize antibody drug conjugates (ADC),it is a PROTAC linker belonging to the PEG class, which can be used to synthesize PROTAC molecules.
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
target
| PEGs
| Non-cleavable
|
Mal-PEG1-acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Mal-PEG1-acid manufacturers
- Product
- Mal-PEG1-acid 760952-64-5
- Price
- US $0.00/g
- Min. Order
- 5g
- Purity
- >98.00%
- Supply Ability
- 5g
- Release date
- 2024-03-27