TCO-PEG4-NHS ester
- Product Name
- TCO-PEG4-NHS ester
- CAS No.
- 1613439-69-2
- Chemical Name
- TCO-PEG4-NHS ester
- Synonyms
- TCO-PEG4-NHS ester;(4E)-TCO-PEG4-NHS ester;2,5-Dioxopyrrolidin-1-yl 1-(cyclooct-4-en-1-yloxy)-1-oxo-5,8,11,14-tetraoxa-2-azaheptadecan-17-oate;(Z)-2,5-dioxopyrrolidin-1-yl 1-(cyclooct-4-en-1-yloxy)-1-oxo-5,8,11,14-tetraoxa-2-azaheptadecan-17-oate;5,8,11,14-Tetraoxa-2-azaheptadecanedioic acid, 1-(4-cycloocten-1-yl) 17-(2,5-dioxo-1-pyrrolidinyl) ester
- CBNumber
- CB93062671
- Molecular Formula
- C24H38N2O10
- Formula Weight
- 514.57
- MOL File
- 1613439-69-2.mol
TCO-PEG4-NHS ester Property
- Density
- 1.23±0.1 g/cm3(Predicted)
- solubility
- Soluble in DMSO, DCM, DMF
- pka
- 11.95±0.46(Predicted)
- form
- Oil
- color
- Colorless to light yellow
- InChI
- InChI=1S/C24H38N2O10/c27-21-8-9-22(28)26(21)36-23(29)10-12-31-14-16-33-18-19-34-17-15-32-13-11-25-24(30)35-20-6-4-2-1-3-5-7-20/h1-2,20H,3-19H2,(H,25,30)/b2-1-
- InChIKey
- ZKPMRASGLDBKPF-UPHRSURJSA-N
- SMILES
- C(OC1CCCC=CCC1)(=O)NCCOCCOCCOCCOCCC(ON1C(=O)CCC1=O)=O |c:6|
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- BP-22418
- Product name
- TCO-PEG4-NHSester
- Purity
- 95%
- Packaging
- 10mg
- Price
- $139
- Updated
- 2021/12/16
- Product number
- BP-22418
- Product name
- TCO-PEG4-NHSester
- Purity
- 95%
- Packaging
- 25mg
- Price
- $235
- Updated
- 2021/12/16
- Product number
- BP-22418
- Product name
- TCO-PEG4-NHSester
- Purity
- 95%
- Packaging
- 100mg
- Price
- $575
- Updated
- 2021/12/16
TCO-PEG4-NHS ester Chemical Properties,Usage,Production
Description
TCO-PEG4-NHS Ester is a click chemistry crosslinker. This reagent can be used to label antibodies, proteins and other primary amine containing molecule. The hydrophilic PEG spacer increases water-solubility and decreases steric hindrance during ligation. TCO enable fast click chemistry under mild condition
Biological Activity
TCO-PEG4-NHS ester is a PROTAC linker and belongs to the PEG class,it can be used to synthesize a series of PROTAC molecules.It is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| Cleavable
| PEGs
|