19-Norethindrone acetate
- Product Name
- 19-Norethindrone acetate
- CAS No.
- 51-98-9
- Chemical Name
- 19-Norethindrone acetate
- Synonyms
- NORETHISTERONE ACETATE;NORETHINDRONE ACETATE;ENTA;Aygestin;sh420;17-Ent;SH 420;SH-420C;Orlutate;progylut
- CBNumber
- CB9307049
- Molecular Formula
- C22H28O3
- Formula Weight
- 340.46
- MOL File
- 51-98-9.mol
19-Norethindrone acetate Property
- Melting point:
- 161-162°
- Boiling point:
- 416.25°C (rough estimate)
- Density
- 1.1236 (rough estimate)
- refractive index
- -34 ° (C=1, Dioxane)
- storage temp.
- 2-8°C
- solubility
- Practically insoluble in water, freely soluble in methylene chloride, soluble in alcohol.
- form
- Solid
- color
- Crystals from Me2CO/hexane
- Water Solubility
- 3.162mg/L(10 ºC)
- Merck
- 14,6697
- InChIKey
- IMONTRJLAWHYGT-ZCPXKWAGSA-N
- CAS DataBase Reference
- 51-98-9(CAS DataBase Reference)
- NIST Chemistry Reference
- Norethindrone acetate(51-98-9)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H351Suspected of causing cancer
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- R752029
- Product name
- NORETHINDRONE ACETATE
- Purity
- AldrichCPR
- Packaging
- 50MG
- Price
- $179
- Updated
- 2024/03/01
- Product number
- R182265
- Product name
- NORETHISTERONE ACETATE
- Purity
- AldrichCPR
- Packaging
- 1MG
- Price
- $139
- Updated
- 2024/03/01
- Product number
- PHR2534
- Product name
- Norethindrone acetate
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 200MG
- Price
- $158
- Updated
- 2024/03/01
- Product number
- BP267
- Product name
- Norethisterone acetate
- Purity
- British Pharmacopoeia (BP) Reference Standard
- Packaging
- 100MG
- Price
- $257
- Updated
- 2024/03/01
- Product number
- 1470004
- Product name
- Norethindrone acetate
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 100mg
- Price
- $436
- Updated
- 2024/03/01
19-Norethindrone acetate Chemical Properties,Usage,Production
Chemical Properties
White Solid
Originator
Norlestrin,Parke Davis ,US,1964
Uses
Progesteron. Norethindrone and acetate in combination with estrogen as contraceptive (oral). It is reasonably anticipated to be a human carcinogen.
Uses
Oral contraceptive (in combination with estrogen)
Definition
ChEBI: A 3-oxo Delta4-steroid that is norethisterone in which the hydroxy group has been converted to its acetate ester.
Manufacturing Process
2.98 grams of 17-ethinyl-19-nor-testosterone (norethindrone) are suspended in 30 cc of acetic anhydride and a solution of 1.9 grams of p-toluenesulfonic acid in 19 cc of acetic anhydride is gradually added while cooling and stirring. Complete dissolution takes place after about one hour. After additional 30 to 60 minutes, a thick, pasty mass separates. The reaction is permitted to continue for a total period of 5 hours, whereupon water is added to the reaction mixture and the 3-enol-17-diacetate which separates after stirring for 1 to 2 hours is filtered off, washed until neutral and dried in vacuo over calcium chloride at room temperature.
In order to prepare the monoacetate, the crude diacetate is suspended in 150 cc of methanol and, after adding 1.5 cc, concentrated hydrochloric acid, heated to boiling for 15 minutes in a nitrogen atmosphere. The crude monoacetate which separates upon the addition of water after cooling is filtered off, washed and dried in vacuo over calcium chloride at room temperature. The pure 17-acetete, obtained after repeated recrystallizations from methylene chloride/hexane has a MP of 161° to 162°C.
brand name
Aygestin (Duramed); Norlutate (Parke-Davis).
Therapeutic Function
Chemical Name: 19-Nor-17α-pregn-4-en-20-yn-3one, 17-hydroxy-, acetate
General Description
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
Safety Profile
Suspected carcinogen with experimental tumorigenic data. Human reproductive effects by ingestion and implant routes: menstrual cycle changes, postpartum effects, and changes in fertility. A human teratogen by an unspecified route with developmental abnormalities of the urogenital system. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. Used in the treatment of menstrual dsorders and uterine bleedmg.
19-Norethindrone acetate Preparation Products And Raw materials
Raw materials
Preparation Products
19-Norethindrone acetate Suppliers
- Tel
- --
- Fax
- --
- dantas@lanzapharma.com
- Country
- Brazil
- ProdList
- 84
- Advantage
- 58
View Lastest Price from 19-Norethindrone acetate manufacturers
- Product
- Norethisterone Acetate 51-98-9
- Price
- US $0.00/Kg/Bag
- Min. Order
- 1KG
- Purity
- 97%-103%; USP
- Supply Ability
- 100KGS
- Release date
- 2021-07-23
- Product
- 19-Norethindrone acetate 51-98-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500
- Release date
- 2023-07-31
- Product
- norethisterone acetate 51-98-9
- Price
- US $40.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10 tons
- Release date
- 2023-09-25