19-Norethindrone acetate

Product Name: 19-Norethindrone acetate
CAS No.: 51-98-9
Chemical Name: 19-Norethindrone acetate
Synonyms: NORETHISTERONE ACETATE;NORETHINDRONE ACETATE;ENTA;Aygestin;sh420;17-Ent;SH 420;SH-420C;Orlutate;progylut
CBNumber: CB9307049
Molecular Formula: C22H28O3
Formula Weight: 340.46
MOL File: 51-98-9.mol

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19-Norethindrone acetate Property

Melting point:: 161-162°
Boiling point:: 416.25°C (rough estimate)
Density: 1.1236 (rough estimate)
refractive index: -34 ° (C=1, Dioxane)
storage temp.: 2-8°C
solubility: Practically insoluble in water, freely soluble in methylene chloride, soluble in alcohol.
form: Solid
color: Crystals from Me2CO/hexane
Water Solubility: 3.162mg/L(10 ºC)
Merck: 14,6697
InChIKey: IMONTRJLAWHYGT-ZCPXKWAGSA-N
CAS DataBase Reference: 51-98-9(CAS DataBase Reference)
NIST Chemistry Reference: Norethindrone acetate(51-98-9)

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Safety

Hazard Codes: Xn
Risk Statements: 40-48
Safety Statements: 36/37
WGK Germany: 3
RTECS: RC8965000
HS Code: 29372390
Toxicity: dlt-mus-orl 1120 mg/kg/4W MUREAV 26,535,74

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H351Suspected of causing cancer

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: R752029
Product name: NORETHINDRONE ACETATE
Purity: AldrichCPR
Packaging: 50MG
Price: $179
Updated: 2024/03/01

Sigma-Aldrich

Product number: R182265
Product name: NORETHISTERONE ACETATE
Purity: AldrichCPR
Packaging: 1MG
Price: $139
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHR2534
Product name: Norethindrone acetate
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 200MG
Price: $158
Updated: 2024/03/01

Sigma-Aldrich

Product number: BP267
Product name: Norethisterone acetate
Purity: British Pharmacopoeia (BP) Reference Standard
Packaging: 100MG
Price: $257
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1470004
Product name: Norethindrone acetate
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 100mg
Price: $436
Updated: 2024/03/01

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19-Norethindrone acetate Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Norlestrin,Parke Davis ,US,1964

Uses

Progesteron. Norethindrone and acetate in combination with estrogen as contraceptive (oral). It is reasonably anticipated to be a human carcinogen.

Uses

Oral contraceptive (in combination with estrogen)

Definition

ChEBI: A 3-oxo Delta4-steroid that is norethisterone in which the hydroxy group has been converted to its acetate ester.

Manufacturing Process

2.98 grams of 17-ethinyl-19-nor-testosterone (norethindrone) are suspended in 30 cc of acetic anhydride and a solution of 1.9 grams of p-toluenesulfonic acid in 19 cc of acetic anhydride is gradually added while cooling and stirring. Complete dissolution takes place after about one hour. After additional 30 to 60 minutes, a thick, pasty mass separates. The reaction is permitted to continue for a total period of 5 hours, whereupon water is added to the reaction mixture and the 3-enol-17-diacetate which separates after stirring for 1 to 2 hours is filtered off, washed until neutral and dried in vacuo over calcium chloride at room temperature.
In order to prepare the monoacetate, the crude diacetate is suspended in 150 cc of methanol and, after adding 1.5 cc, concentrated hydrochloric acid, heated to boiling for 15 minutes in a nitrogen atmosphere. The crude monoacetate which separates upon the addition of water after cooling is filtered off, washed and dried in vacuo over calcium chloride at room temperature. The pure 17-acetete, obtained after repeated recrystallizations from methylene chloride/hexane has a MP of 161° to 162°C.

brand name

Aygestin (Duramed); Norlutate (Parke-Davis).

Therapeutic Function

Chemical Name: 19-Nor-17α-pregn-4-en-20-yn-3one, 17-hydroxy-, acetate

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Safety Profile

Suspected carcinogen with experimental tumorigenic data. Human reproductive effects by ingestion and implant routes: menstrual cycle changes, postpartum effects, and changes in fertility. A human teratogen by an unspecified route with developmental abnormalities of the urogenital system. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. Used in the treatment of menstrual dsorders and uterine bleedmg.

19-Norethindrone acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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19-Norethindrone acetate Suppliers

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View Lastest Price from 19-Norethindrone acetate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Norethisterone Acetate 51-98-9
Price: US $0.00/Kg/Bag
Min. Order: 1KG
Purity: 97%-103%; USP
Supply Ability: 100KGS
Release date: 2021-07-23

Wuhan Haorong Biotechnology Co.,Ltd

Product: 19-Norethindrone acetate 51-98-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500
Release date: 2023-07-31

Hebei Yanxi Chemical Co., Ltd.

Product: norethisterone acetate 51-98-9
Price: US $40.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10 tons
Release date: 2023-09-25

51-98-9, 19-Norethindrone acetateRelated Search:

Isopropyl acetate Vinyl acetate 1-Methoxy-2-propyl acetate Glatiramer acetate Ethyl acetate POLY(VINYL ACETATE) Ethylene glycol monoethyl ether acetate Sodium acetate CHLOROPHOSPHONAZO III (-)-NORGESTREL 98 Cellulose acetate Norethindrone 2-Butoxyethyl acetate Ammonium acetate Norgestrel ACETATE NOR-1 Ethinylestradiol/Norethindrone acetate

SH-420C

4-ESTREN-17ALPHA-ETHYNYL-17BETA-OL-3-ONE 17-ACETATE

4-ESTREN-17-ALPHA-ETHYNYL-17-BETA-OL-3-ONE ACETATE

ACETIC ACID 17-ETHYNYL-13-METHYL-3-OXO-2,3,6,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPE

19-NORETHISTERONE 17-ACETATE MIN. 98 % (

NORETHISTERONE ACETATE, EP STANDARD

NORETHISTERONE ACETATE, IMP. A (EP): NORETHISTERONE MM(CRM STANDARD)

NORETHISTERONE ACETATE, WHO STANDARD

NORETHISTERONE ACETATE, IMP. G (EP): 6-KETONORETHISTERONE ACETATE, MM(CRM STANDARD)

NORETHISTERONE ACETATE 98+%

NORETHINDRONE ACETATE CRYSTALLINE

NORETHISTERONE ACETATE, IMP. F (EP): 6-HYDROXYNORETHISTERONE ACETATE, MM(CRM STANDARD)

NORETHISTERONE ACETATE, USP STANDARD

NORETHISTERONE ACETATE, IMP. B (EP): 3-OXO-19-NOR-17ALPHA-PREGN-5(10-EN-20YN-17YL ACETATE MM(CRM STANDARD)

NORETHISTERONE ACETATE, MM(CRM STANDARD)

NorethisteroneAcetateBp93

17-Hydroxy-19-nor-17α-pregn-4-en-20-yn-3-one acetate

17α-ethynyl-17β-hydroxy-19-nor-4-androsten-3-one 17-acetate

19-NOR-17ALPHA-ETHYNYLTESTOSTERONE ACETATE

19-NORESTHISTERONE ACETATE

19-NORETHINDRONE ACETATE

19-NORETHISTERONE 17-ACETATE

19-NORETHISTERONE ACETATE

17a-ethynyl-19-nortestosterone 17b-acetate

17ALPHA-ETHYNYL-17BETA-HYDROXY-19-NOR-4-ANDROSTEN-3-ONE 17-ACETATE

17ALPHA-ETHYNYL-19-NORTESTOSTERONE ACETATE

17ALPHA-ETHYNYL-19-NORTESTOSTERONE 17BETA-ACETATE

17-hydroxy-19-nor-17a-4-pregnen-20-yn-3-one acetate

17-HYDROXY-19-NOR-17ALPHA-4-PREGNEN-20-YN-3-ONE ACETATE

Norethisterone acetate for system suitability

NORETHINDRONE ACETATE

NORETHISTERONE ACETATE

acetic acid (17-ethynyl-13-methyl-3-oxo-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-yl) ester

17-acetyloxy(17-alpha)-19-norpregn-4-estren-17-beta-ol-acetate-3-one

17-Acetyloxy(17alpha)-19-norpregn-4-estren-17beta-ol-acetate-3-one

17alpha-Ethinyl-19-nortestosterone 17beta-acetate

17alpha-Ethinyl-19-nortestosterone acetate

17-alpha-ethinyl-19-nortestosterone-17-beta-acetate

17-alpha-ethinyl-19-nortestosteroneacetate

17-alpha-ethynyl-17-beta-acetoxy-19-norandrost-4-en-3-one

17alpha-Ethynyl-17beta-acetoxy-19-norandrost-4-en-3-one

17alpha-Ethynyl-17-hydroxyestr-4-en-3-one acetate

17-alpha-ethynyl-17-hydroxyestr-4-en-3-oneacetate

17-beta-acetoxy-19-nor-17-alpha-pregn-4-en-20-yn-3-one

17beta-Acetoxy-19-nor-17alpha-pregn-4-en-20-yn-3-one

17beta-Hydroxy-19-nor-17alpha-pregn-4-en-20-yn-3-one acetate

(17-alpha)-17-(Acetyloxy)-19-norpregn-4-en-20-yn-3-one

(17α)-17-(acetyloxy)-19-norpregn-4-en-20-yn-3-one

17-acetoxy-19-nor-17-alpha-pregn-4-en-20-yn-3-on

17-acetoxy-19-nor-17-alpha-pregn-4-en-20-yn-3-one

17-Acetoxy-19-nor-17alpha-pregn-4-en-20-yn-3-one

17-beta-hydroxy-19-nor-17-alpha-pregn-4-en-20-yn-3-oneacetate

17beta-Hydroxy-19-norpregn-4-en-20-yn-3-one acetate

17-Ent

17-Ethynyl-3-oxoestr-4-en-17-yl acetate

17-Hydroxy-19-nor-17alpha-pregn-4-en-20-yn-3-one acetate

17-hydroxy-19-nor-17-alpha-pregn-4-en-20-yn-3-oneacetate

17-Acetyloxy-17-ethinylestr-4-en-3-one