Cilazapril

Product Name: Cilazapril
CAS No.: 88768-40-5
Chemical Name: Cilazapril
Synonyms: Vascace;(1S,9S)-;Yipingshu;Ro34-2848;Cilazapril;Ro 31-2848;Ro 34-2848;Ro-34-2848;CILASTATIN NA;Cilazapril USP/EP/BP
CBNumber: CB9307140
Molecular Formula: C22H31N3O5
Formula Weight: 417.5
MOL File: 88768-40-5.mol

More

Less

Cilazapril Property

Melting point:: 95-97°C
Boiling point:: 598.1±60.0 °C(Predicted)
Density: 1.26±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly)
form: powder
pka: 2.28±0.20(Predicted)
color: White to Off-White
CAS DataBase Reference: 88768-40-5(CAS DataBase Reference)

More

Less

Safety

Safety Statements: 22-24/25
WGK Germany: 3
RTECS: MJ9650200

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 29777
Product name: Cilazapril
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 29777
Product name: Cilazapril
Packaging: 5mg
Price: $78
Updated: 2024/03/01

Cayman Chemical

Product number: 29777
Product name: Cilazapril
Packaging: 10mg
Price: $122
Updated: 2024/03/01

Cayman Chemical

Product number: 29777
Product name: Cilazapril
Packaging: 25mg
Price: $267
Updated: 2024/03/01

TRC

Product number: C441200
Product name: Cilazapril
Packaging: 25mg
Price: $290
Updated: 2021/12/16

More

Less

Cilazapril Chemical Properties,Usage,Production

Description

Cilazapril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor cilazaprilat. In vivo, cilazapril (0.1 mg/kg) inhibits plasma ACE activity and inhibits the angiotensin I-induced pressor response in anesthetized rats and cats. It decreases systolic blood pressure in spontaneously hypertensive rats when administered at a dose of 30 mg/kg. Cilazapril (10 mg/kg, p.o.) decreases blood pressure in volume-depleted renal hypertensive dogs. Formulations containing cilazapril have been used in the treatment of hypertension.

Chemical Properties

Off-White Solid

Uses

An ACE inhibitor. Hydrolyzed in vivo to the active diacid metabolite (Cilazaprilat). Antihypertensive.

Definition

ChEBI: Cilazapril is a pyridazinodiazepine resulting from the formal condensation of the carboxy group of cilazaprilat with ethanol. It is a drug used in the treatment of hypertension and heart failure. It has a role as a prodrug, an antihypertensive agent and an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor. It is an ethyl ester, a pyridazinodiazepine and a dicarboxylic acid monoester. It is functionally related to a Cilazaprilat.

brand name

Inhibace (Hoffmann-LaRoche).

Cilazapril Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Cilazapril Suppliers

Canada 2 China 37 Europe 2 France 1 Germany 1 India 10 Japan 1 Switzerland 1 United Kingdom 6 United States 21 Global 82

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2127
Advantage: 70

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 18521732826;
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25004
Advantage: 65

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4863
Advantage: 58

Cato Research Chemicals Inc.

Tel: 020-81960175
Fax: +1-541-2553641
Email: min.he@cato-chem.com
Country: China
ProdList: 1958
Advantage: 55

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7893
Advantage: 56

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 18112977050
Email: cb6@aikonchem.com
Country: China
ProdList: 16687
Advantage: 50

Hangzhou Cheminspire Technology Co., Ltd.

Tel: 0571-89081561; 10006559855
Fax: 0571 89081561
Email: info@cheminspire.com
Country: China
ProdList: 412
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131981
Advantage: 58

More

Less

View Lastest Price from Cilazapril manufacturers

Dideu Industries Group Limited

Product: Cilazapril 88768-40-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-08-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Cilazapril 88768-40-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Cilazapril 88768-40-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

88768-40-5, CilazaprilRelated Search:

CILAZAPRIL EPC(CRM STANDARD),CILAZAPRIL EPC( DELAPRIL Lithium diisopropylamide DIAZOXIDE Carbonyl iron powder NITROUS OXIDE Ethyl N-(2-butyl)glycinate 2,2'-(ETHYLENEDIIMINO)-DIBUTYRIC ACID Cilastatin Cilazaprilat Cilastatin sodium L-Homophenylalanine ethyl ester L-β-Homophenylalanine, HPLC 98% CILAZAPRIL CILAZAPRIL IMPURITY D CILAZAPRIL IMPURITY A HEXAHYDROPYRIDAZINE-3-CARBOXYLIC ACID Cilazapril

6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid, 9-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-, (1S,9S)-

6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid, 9-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-, [1S-[1α,9α(R*)]]-

Ro 31-2848

Yipingshu

CILASTATIN NA

CILASTATIN SODIUM SALT

sodium hydrogen 7-[(2-amino-2-carboxylatoethyl)thio]-2-[[(2,2-dimethylcyclopropyl)carbonyl]amino]hept-2-enoate

(1S,9S)-9-[(S)-1-Ethoxycarbonyl-3-phenylpropylamino]-10-oxoperhydropyridazino[1,2-a][1,2]diazepine-1-carboxylic acid

Cilazapril

(1S,9S)-9-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-α][1,2]diazepine-1-carboxylic Acid

Vascace

(1S,9S)-9-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-10-oxooctahydro-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid

(1S,9S)-9-[[(S)-1-Ethoxycarbonyl-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid

(1S,9S)-

(1S,9S)-9-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic Acid

Cilazapril USP/EP/BP

Cilazapril (anhydrous)

Ro 34-2848

Ro-34-2848

Ro34-2848

88768-40-5

Chiral Reagents

API

Intermediates & Fine Chemicals

Pharmaceuticals