Cilazapril

Product Name: Cilazapril
CAS No.: 88768-40-5
Chemical Name: Cilazapril
Synonyms: Vascace;(1S,9S)-;Yipingshu;Ro34-2848;Cilazapril;Ro 31-2848;Ro 34-2848;Ro-34-2848;CILASTATIN NA;Cilazapril USP/EP/BP
CBNumber: CB9307140
Molecular Formula: C22H31N3O5
Formula Weight: 417.5
MOL File: 88768-40-5.mol

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Cilazapril Property

Melting point:: 95-97°C
Boiling point:: 598.1±60.0 °C(Predicted)
Density: 1.26±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly)
form: powder
pka: 2.28±0.20(Predicted)
color: White to Off-White
CAS DataBase Reference: 88768-40-5(CAS DataBase Reference)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
RTECS: MJ9650200

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29777
Product name: Cilazapril
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 29777
Product name: Cilazapril
Packaging: 5mg
Price: $78
Updated: 2024/03/01

Cayman Chemical

Product number: 29777
Product name: Cilazapril
Packaging: 10mg
Price: $122
Updated: 2024/03/01

Cayman Chemical

Product number: 29777
Product name: Cilazapril
Packaging: 25mg
Price: $267
Updated: 2024/03/01

TRC

Product number: C441200
Product name: Cilazapril
Packaging: 25mg
Price: $290
Updated: 2021/12/16

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Cilazapril Chemical Properties,Usage,Production

Description

Cilazapril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor cilazaprilat. In vivo, cilazapril (0.1 mg/kg) inhibits plasma ACE activity and inhibits the angiotensin I-induced pressor response in anesthetized rats and cats. It decreases systolic blood pressure in spontaneously hypertensive rats when administered at a dose of 30 mg/kg. Cilazapril (10 mg/kg, p.o.) decreases blood pressure in volume-depleted renal hypertensive dogs. Formulations containing cilazapril have been used in the treatment of hypertension.

Chemical Properties

Off-White Solid

Uses

An ACE inhibitor. Hydrolyzed in vivo to the active diacid metabolite (Cilazaprilat). Antihypertensive.

Definition

ChEBI: Cilazapril is a pyridazinodiazepine resulting from the formal condensation of the carboxy group of cilazaprilat with ethanol. It is a drug used in the treatment of hypertension and heart failure. It has a role as a prodrug, an antihypertensive agent and an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor. It is an ethyl ester, a pyridazinodiazepine and a dicarboxylic acid monoester. It is functionally related to a Cilazaprilat.

brand name

Inhibace (Hoffmann-LaRoche).

Cilazapril Preparation Products And Raw materials

Raw materials

Preparation Products

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Cilazapril Suppliers

Canada 2 China 38 Europe 2 France 1 Germany 1 India 10 Japan 1 Switzerland 1 United Kingdom 6 United States 21 Global 83

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View Lastest Price from Cilazapril manufacturers

Dideu Industries Group Limited

Product: Cilazapril 88768-40-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-08-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Cilazapril 88768-40-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Cilazapril 88768-40-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

88768-40-5, CilazaprilRelated Search:

CILAZAPRIL EPC(CRM STANDARD),CILAZAPRIL EPC( DELAPRIL Lithium diisopropylamide DIAZOXIDE Carbonyl iron powder NITROUS OXIDE Ethyl N-(2-butyl)glycinate 2,2'-(ETHYLENEDIIMINO)-DIBUTYRIC ACID Cilastatin Cilazaprilat Cilastatin sodium L-Homophenylalanine ethyl ester L-β-Homophenylalanine, HPLC 98% CILAZAPRIL CILAZAPRIL IMPURITY D CILAZAPRIL IMPURITY A HEXAHYDROPYRIDAZINE-3-CARBOXYLIC ACID Cilazapril

6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid, 9-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-, (1S,9S)-

6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid, 9-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-, [1S-[1α,9α(R*)]]-

Ro 31-2848

Yipingshu

CILASTATIN NA

CILASTATIN SODIUM SALT

sodium hydrogen 7-[(2-amino-2-carboxylatoethyl)thio]-2-[[(2,2-dimethylcyclopropyl)carbonyl]amino]hept-2-enoate

(1S,9S)-9-[(S)-1-Ethoxycarbonyl-3-phenylpropylamino]-10-oxoperhydropyridazino[1,2-a][1,2]diazepine-1-carboxylic acid

Cilazapril

(1S,9S)-9-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-α][1,2]diazepine-1-carboxylic Acid

Vascace

(1S,9S)-9-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-10-oxooctahydro-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid

(1S,9S)-9-[[(S)-1-Ethoxycarbonyl-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid

(1S,9S)-

(1S,9S)-9-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic Acid

Cilazapril USP/EP/BP

Cilazapril (anhydrous)

Ro 34-2848

Ro-34-2848

Ro34-2848

88768-40-5

Chiral Reagents

API

Intermediates & Fine Chemicals

Pharmaceuticals