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Sacubitril Impurity

Product Name: Sacubitril Impurity
CAS No.: 1015037-46-3
Chemical Name: Sacubitril Impurity
Synonyms: impurity 41;Sacubitril Impurity;1012341-48-8 enantioMer;Sacubitril Impurity 103;LCZ696 valsartan + sacubitril impurity 41;(S,E)-5-([1,1'-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic acid;(2E,4S)-5-[1,1-Biphenyl]-4-yl-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-2-pentenoic Acid;(2E,4S)-5-[1,1'-Biphenyl]-4-yl-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-2-pentenoic acid;2-Pentenoic acid, 5-[1,1'-biphenyl]-4-yl-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-, (2E,4S)-
CBNumber: CB93122683
Molecular Formula: C23H27NO4
Formula Weight: 381.46
MOL File: 1015037-46-3.mol

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Sacubitril Impurity Property

Boiling point:: 595.6±50.0 °C(Predicted)
Density: 1.132±0.06 g/cm3(Predicted)
storage temp.: Storage temp. 2-8°C
pka: 4.67±0.19(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C23H27NO4/c1-16(21(25)26)14-20(24-22(27)28-23(2,3)4)15-17-10-12-19(13-11-17)18-8-6-5-7-9-18/h5-14,20H,15H2,1-4H3,(H,24,27)(H,25,26)/b16-14+/t20-/m1/s1
InChIKey: JXTNUXJSXXIIFE-KETLNSEPSA-N
SMILES: C(O)(=O)/C(/C)=C/[C@@H](NC(OC(C)(C)C)=O)CC1=CC=C(C2=CC=CC=C2)C=C1

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Hazard and Precautionary Statements (GHS)

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Sacubitril Impurity Chemical Properties,Usage,Production

Uses

(2E,4S)-5-[1,1''-Biphenyl]-4-yl-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-2-pentenoic Acid was used in the study to process for preparation of biaryl-substituted 4-aminobutyric acids by hydrogenation of the corresponding alkenoates.

Sacubitril Impurity Preparation Products And Raw materials

Raw materials

Preparation Products

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1015037-46-3, Sacubitril ImpurityRelated Search:

Sacubitril Impurity 19 (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoic acid hydrochloride ahu377 isomer 2 LCZ Impurity (2S,4R)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid LCZ696 InteMediate sacubitril AHU-377 Sacubitril Impurity 31 Ethyl (2R,4S)-4-([1,1'-biphenyl]-4-ylmethyl)-2-methyl-4-(2,5-dioxopyrrolidin-1-yl)butanoate 2-Pyrrolidinone, 5-([1,1'-biphenyl]-4-ylMethyl)-3-Methyl-, (3R,5S)- Sacubitril Impurity 14 Sacubitril impurity 030 Sacubitril Impurity 17 Sacubitril Impurity 15 Sacubitril Impurity 20 Sacubitril Impurity 13 Sacubitril Impurity 16

1012341-48-8 enantioMer

(2E,4S)-5-[1,1-Biphenyl]-4-yl-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-2-pentenoic Acid

impurity 41

2-Pentenoic acid, 5-[1,1'-biphenyl]-4-yl-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-, (2E,4S)-

Sacubitril Impurity

(S,E)-5-([1,1'-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic acid

Sacubitril Impurity 103

(2E,4S)-5-[1,1'-Biphenyl]-4-yl-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-2-pentenoic acid

LCZ696 valsartan + sacubitril impurity 41

1015037-46-3