ChemicalBook > CAS DataBase List > Siremadlin

Siremadlin

Product Name
Siremadlin
CAS No.
1448867-41-1
Chemical Name
Siremadlin
Synonyms
Siremadlin;HDM-201;CS-2787;CS-2613;NVP-HDM201;Siremadlin，HDM 201;NVP-HDM201 S-ISOMER;HDM201 (Siremadlin);Siremadlin (NVP-HDM201);HDM201 (Siremadlin) HCl
CBNumber
CB93133461
Molecular Formula
C26H24Cl2N6O4
Formula Weight
555.41
MOL File
1448867-41-1.mol
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Siremadlin Property

Boiling point:
736.5±70.0 °C(Predicted)
Density 
1.47±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : ≥ 56.75 mg/mL (102.18 mM)
form 
Solid
pka
1.33±0.29(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-7654
Product name
Siremadlin
Purity
99.82%
Packaging
1mg
Price
$70
Updated
2021/12/16
ChemScene
Product number
CS-7654
Product name
Siremadlin
Purity
99.82%
Packaging
5mg
Price
$150
Updated
2021/12/16
Biosynth Carbosynth
Product number
BH166424
Product name
NVP HDM 201
Packaging
10mg
Price
$175
Updated
2021/12/16
ChemScene
Product number
CS-7654
Product name
Siremadlin
Purity
99.82%
Packaging
10mg
Price
$220
Updated
2021/12/16
AK Scientific
Product number
1697DV
Product name
Siremadlin
Packaging
10mg
Price
$286
Updated
2021/12/16
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Siremadlin Chemical Properties,Usage,Production

Uses

Siremadlin is an oral biologic agent that is a selective inhibitor of the p53-MDM2 interaction and is being investigated for the treatment of patients with myeloid malignancies after showing single agent activity in preclinical studies. the safety profile of Siremadlin did not differ significantly between tumor types and treatment regimens.

Siremadlin Preparation Products And Raw materials

Raw materials

Preparation Products

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Siremadlin Suppliers

China 62 United States 7 Global 69
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View Lastest Price from Siremadlin manufacturers

Career Henan Chemical Co
Product
(6S)-5-(5-chloro-1,2-dihydro-1-methyl-2-oxo-3-pyridinyl)-6-(4-chlorophenyl)-2-(2,4-dimethoxy-5-pyrimidinyl)-5,6-dihydro-1-(1-methylethyl)-Pyrrolo[3,4-d]imidazol-4(1H)-one 1448867-41-1
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1lg; 2kg; 5kg; 10kg; 100kg
Release date
2019-08-31

1448867-41-1, SiremadlinRelated Search:

NVP-BAW2881 6-[[2-[[2-(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethyl]amino]ethyl]amino-3-pyridinecarbononitriledihydrochloride NVP-BSK805 NVP-BGT226 N-[2-(Benzoylamino)-6-benzothiazolyl]tricyclo[3.3.1.13,7]decane-1-carboxamide TAE226 (NVP-TAE226) NVP-LCQ195 NVP-TAE684 NVP-BEZ 235

  • (6S)-5-(5-chloro-1,2-dihydro-1-methyl-2-oxo-3-pyridinyl)-6-(4-chlorophenyl)-2-(2,4-dimethoxy-5-pyrimidinyl)-5,6-dihydro-1-(1-methylethyl)-Pyrrolo[3,4-d]imidazol-4(1H)-one
  • HDM-201
  • NVP-HDM201
  • CS-2613
  • CS-2787
  • HDM201; HDM 201; HDM-201; NVP-HDM201; NVP-HDM-201; NVP-HDM 201
  • (S)-5-(5-chloro-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)-6-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-1-isopropyl-5,6-dihydropyrrolo[3,4-d]imidazol-4(1H)-one
  • Siremadlin
  • NVP-HDM201;HDM-201;NVP-HDM-201
  • Pyrrolo[3,4-d]imidazol-4(1H)-one, 5-(5-chloro-1,2-dihydro-1-methyl-2-oxo-3-pyridinyl)-6-(4-chlorophenyl)-2-(2,4-dimethoxy-5-pyrimidinyl)-5,6-dihydro-1-(1-methylethyl)-, (6S)-
  • Siremadlin (NVP-HDM201)
  • NVP-HDM201 S-ISOMER
  • HDM201 (Siremadlin) HCl
  • Siremadlin，HDM 201
  • HDM 201,E1/E2/E3 Enzyme,MDM-2/p53,E2 conjugating enzyme,HDM201,Inhibitor,HDM-201,Siremadlin,Ubiquitin activating enzyme,E3 ligating enzyme,inhibit,E1 activating enzyme,Ubiquitin ligase,NVP-HDM201,Ubiquitin conjugating enzyme
  • NVP-HDM201(Siremadlin )
  • HDM201 (Siremadlin)
  • NVP-HDM201 (SIREMADLIN) (HDM-201)
  • 1448867-41-1
  • C26H24Cl2N6O4