ChemicalBook > CAS DataBase List > HA-15

HA-15

Product Name
HA-15
CAS No.
1609402-14-3
Chemical Name
HA-15
Synonyms
HA-15;CS-2893;HA15;HA 15;HA15 >=98% (HPLC);HA-15,HSP,HA 15,Inhibitor,HA15,Apoptosis,inhibit,Autophagy,Heat shock proteins;N-(4-(3-((5-(Dimethylamino)naphthalene)-1-sulfonamido)phenyl)thiazol-2-yl)acetamide;Acetamide, N-[4-[3-[[[5-(dimethylamino)-1-naphthalenyl]sulfonyl]amino]phenyl]-2-thiazolyl]-
CBNumber
CB93145837
Molecular Formula
C23H22N4O3S2
Formula Weight
466.58
MOL File
1609402-14-3.mol
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HA-15 Property

Density 
1.406±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:71.5(Max Conc. mg/mL);153.24(Max Conc. mM)
Ethanol:45.0(Max Conc. mg/mL);96.45(Max Conc. mM)
form 
A solid
pka
7.32±0.50(Predicted)
color 
Light yellow to green yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2118
Product name
HA15
Purity
≥98% (HPLC)
Packaging
5MG
Price
$102
Updated
2023/06/20
Sigma-Aldrich
Product number
SML2118
Product name
HA15
Purity
≥98% (HPLC)
Packaging
25MG
Price
$413
Updated
2023/06/20
ChemScene
Product number
CS-5825
Product name
HA15
Purity
99.84%
Packaging
50mg
Price
$420
Updated
2021/12/16
ChemScene
Product number
CS-5825
Product name
HA15
Purity
99.84%
Packaging
100mg
Price
$720
Updated
2021/12/16
ChemScene
Product number
CS-5825
Product name
HA15
Purity
99.84%
Packaging
10mg
Price
$132
Updated
2021/12/16
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HA-15 Chemical Properties,Usage,Production

Definition

ChEBI: HA15 is a sulfonamide resulting from the formal condensation of the sulfonic acid group of 5-(dimethylamino)naphthalene-1-sulfonic acid with the aniline nitrogen of 3-(2-acetamido-1,3-thiazol-4-yl)aniline. It has been reported that by triggering an endoplasmic reticulum (ER) stress response, HA15 can reduce the viability of melanoma cells without being toxic to normal cells. It has a role as an antineoplastic agent. It is a sulfonamide, a member of 1,3-thiazoles, a member of acetamides, a tertiary amino compound, an aminonaphthalene and a biaryl.

Biological Activity

HA15 is a small molecule that specifically targets HSPA5 (Heat shock 70kDa protein 5), also known as BiP (Immunoglobulin heavy-chain-binding protein) or Grp78 (glucose-regulated protein 78). Antitumor activity in melanoma cells tested, including cells isolated from patients and cells resistant to BRAF inhibitors.

in vitro

HA15 induces endoplasmic reticulum stress in cells in vitro, leading to cancer cell death; in melanoma cells, it overcomes its resistance to BRAF inhibitors.

in vivo

In xenograft mouse models (bearing melanoma cells sensitive or resistant to BRAF inhibitors), HA15 was able to induce endoplasmic reticulum stress leading to cancer cell death.

target

TargetValue
BiP/GRP78/HSPA5
()

HA-15 Preparation Products And Raw materials

Raw materials

Preparation Products

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HA-15 Suppliers

China 62 India 1 United States 7 Global 70
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38632
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81

1609402-14-3, HA-15Related Search:

UNC0321 CPI-455 Maritoclax GDC-0623 IMR-1 CHIR 99021 trihydrochloride CEP-18770 LJI308 2-((2-Chlorophenyl)(phenyl)aMino)-N-(7-(hydroxyaMino)-7-oxoheptyl)pyriMidine-5-carboxaMide AZ191 HTH-01-015 GDC-0879 4-iodo-3-nitrobenzamide VBY-825

  • HA-15
  • CS-2893
  • HA15;HA 15
  • Acetamide, N-[4-[3-[[[5-(dimethylamino)-1-naphthalenyl]sulfonyl]amino]phenyl]-2-thiazolyl]-
  • HA15 >=98% (HPLC)
  • N-(4-(3-((5-(Dimethylamino)naphthalene)-1-sulfonamido)phenyl)thiazol-2-yl)acetamide
  • HA-15,HSP,HA 15,Inhibitor,HA15,Apoptosis,inhibit,Autophagy,Heat shock proteins
  • 1609402-14-3