Boc-aminooxy-PEG4-Propargyl

Product Name: Boc-aminooxy-PEG4-Propargyl
CAS No.: 1895922-77-6
Chemical Name: Boc-aminooxy-PEG4-Propargyl
Synonyms: Boc-aminooxy-PEG4-Propargyl;t-Boc-aminooxy-PEG4-propargyl;N-Boc-O-(3,6,9,12-tetraoxapentadec-14-yn-1-yl)hydroxylamine;3,6,9,12,15-Pentaoxa-2-azaoctadec-17-ynoic acid, 1,1-dimethylethyl ester
CBNumber: CB93162908
Molecular Formula: C16H29NO7
Formula Weight: 347.4
MOL File: 1895922-77-6.mol

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Boc-aminooxy-PEG4-Propargyl Property

Density: 1.083±0.06 g/cm3(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-23142
Product name: t-Boc-aminooxy-PEG4-propargyl
Purity: 98%
Packaging: 100mg
Price: $280
Updated: 2021/12/16

BroadPharm

Product number: BP-23142
Product name: t-Boc-aminooxy-PEG4-propargyl
Purity: 98%
Packaging: 250mg
Price: $460
Updated: 2021/12/16

BroadPharm

Product number: BP-23142
Product name: t-Boc-aminooxy-PEG4-propargyl
Purity: 98%
Packaging: 500mg
Price: $680
Updated: 2021/12/16

BroadPharm

Product number: BP-23142
Product name: t-Boc-aminooxy-PEG4-propargyl
Purity: 98%
Packaging: 1g
Price: $1100
Updated: 2021/12/16

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Boc-aminooxy-PEG4-Propargyl Chemical Properties,Usage,Production

Description

t-Boc-aminooxy-PEG4-propargyl is a click chemistry tool containing a propargyl group and t-Boc-aminooxy group. Propargyl group is reactive with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry to yield a stable triazole linkage. T-Boc-aminooxy can be deprotected under mild acidic conditions and then can react with an aldehyde or ketone group to form a linkage. The hydrophilic PEG spacer increases solubility in aqueous media.

Uses

Boc-aminooxy-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Boc-aminooxy-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs

References

[1] Zhao B, et al. Protein Engineering in the Ubiquitin System: Tools for Discovery and Beyond. Pharmacol Rev. 2020 Apr;72(2):380-413. DOI:10.1124/pr.118.015651

Boc-aminooxy-PEG4-Propargyl Preparation Products And Raw materials

Raw materials

Preparation Products

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Boc-aminooxy-PEG4-Propargyl Suppliers

China 17 United States 2 Global 19

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

Combi-Blocks Inc.

Tel: --
Fax: --
Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

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Boc-aminooxy-PEG4-Propargyl

t-Boc-aminooxy-PEG4-propargyl

3,6,9,12,15-Pentaoxa-2-azaoctadec-17-ynoic acid, 1,1-dimethylethyl ester

N-Boc-O-(3,6,9,12-tetraoxapentadec-14-yn-1-yl)hydroxylamine

1895922-77-6