TYRPHOSTIN B48
- Product Name
- TYRPHOSTIN B48
- CAS No.
- 133550-35-3
- Chemical Name
- TYRPHOSTIN B48
- Synonyms
- 494;AG 494;CS-2755;TYRPHOSTIN B48;-494 Tyrphostin;TYRPHOSTIN AG 494;AG-494 Tyrphostin;TyrphostinAG494>AG-494;AG 494;AG494;AG 494 (Tyrphostin AG 494)
- CBNumber
- CB9319132
- Molecular Formula
- C16H12N2O3
- Formula Weight
- 280.28
- MOL File
- 133550-35-3.mol
TYRPHOSTIN B48 Property
- Melting point:
- 249 °C(dec.)
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- solubility
- DMSO: soluble
- form
- Yellow solid.
- color
- Light yellow to Amber to Dark green
Safety
- Safety Statements
- 22-24/25
- RIDADR
- 3439
- WGK Germany
- 3
- HS Code
- 2926.90.4801
- HazardClass
- 6.1
- PackingGroup
- III
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A2704
- Product name
- Tyrphostin AG 494
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 20mg
- Price
- $91
- Updated
- 2024/03/01
- Product number
- A2704
- Product name
- Tyrphostin AG 494
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 100mg
- Price
- $275
- Updated
- 2024/03/01
- Product number
- 10010242
- Product name
- AG-494
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $34
- Updated
- 2024/03/01
- Product number
- 10010242
- Product name
- AG-494
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $64
- Updated
- 2024/03/01
- Product number
- 10010242
- Product name
- AG-494
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $150
- Updated
- 2024/03/01
TYRPHOSTIN B48 Chemical Properties,Usage,Production
Description
Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative, compounds that act as PTK blockers. PTK inhibitors that preferentially inhibit the epidermal growth factor (EGF) receptor kinase block EGF-
Biological Activity
Potent inhibitor of epidermal growth factor receptor (EGFR) kinase (IC 50 = 0.7 μ M). Selective over ErbB2, PDGFR and insulin receptor kinase (IC 50 values are 42, 6 and > 100 μ M respectively).
References
[1]. osherov n, levitzki a. tyrphostin ag 494 blocks cdk2 activation. febs lett, 1997, 410(2-3): 187-190.
[2]. kleinberger-doron n, shelah n, capone r, et al. inhibition of cdk2 activation by selected tyrphostins causes cell cycle arrest at late g1 and s phase. exp cell res, 1998, 241(2): 340-351.
[3]. liu x, qin j, luo q, et al. cross-talk between egf and bmp9 signalling pathways regulates the osteogenic differentiation of mesenchymal stem cells. j cell mol med, 2013, 17(9): 1160-1172.
[4]. bojko a1, reichert k, adamczyk a, et al. the effect of tyrphostins ag494 and ag1478 on the autocrine growth regulation of a549 and du145 cells. folia histochem cytobiol, 2012, 50(2): 186-195.
TYRPHOSTIN B48 Preparation Products And Raw materials
Raw materials
Preparation Products
TYRPHOSTIN B48 Suppliers
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77
- Tel
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- Fax
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- kevinbanks@molekula.com
- Country
- United Kingdom
- ProdList
- 6140
- Advantage
- 66
- Tel
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- Fax
- --
- vernam@fluorochem.co.uk
- Country
- United Kingdom
- ProdList
- 6375
- Advantage
- 65
- Tel
- --
- Fax
- --
- enquiries@fluorochem.co.uk
- Country
- United Kingdom
- ProdList
- 6401
- Advantage
- 74
- Tel
- --
- Fax
- --
- solutions@vwr.com
- Country
- United Kingdom
- ProdList
- 6548
- Advantage
- 82
View Lastest Price from TYRPHOSTIN B48 manufacturers
- Product
- TYRPHOSTIN B48 133550-35-3
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.99%
- Supply Ability
- 200kg
- Release date
- 2019-12-24