ChemicalBook > CAS DataBase List > (S)-(+)-2-Amino-3-methyl-1-butanol

(S)-(+)-2-Amino-3-methyl-1-butanol

Product Name
(S)-(+)-2-Amino-3-methyl-1-butanol
CAS No.
2026-48-4
Chemical Name
(S)-(+)-2-Amino-3-methyl-1-butanol
Synonyms
L-VALINOL;L-VALINAL;S-VALINOL;H-VAL-OL;l-2-amino-3-methylbutan-1-ol;L-2-AMINO-3-METHYL-1-BUTANOL;(S)-2-AMINO-3-METHYL-1-BUTANOL;M0;val-ol;L-Valino
CBNumber
CB9319657
Molecular Formula
C5H13NO
Formula Weight
103.16
MOL File
2026-48-4.mol
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(S)-(+)-2-Amino-3-methyl-1-butanol Property

Melting point:
30-34 °C
Boiling point:
81 °C8 mm Hg(lit.)
alpha 
16 º (c=10,EtOH)
Density 
0.926 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.4548(lit.)
Flash point:
196 °F
storage temp. 
Store at +2°C to +8°C.
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
12.82±0.10(Predicted)
form 
Liquid After Melting
color 
Clear slightly yellow
optical activity
[α]25/D +10°, c = 10 in H2O
Water Solubility 
Soluble in water.
Sensitive 
Air Sensitive
BRN 
1719137
InChIKey
NWYYWIJOWOLJNR-RXMQYKEDSA-N
CAS DataBase Reference
2026-48-4(CAS DataBase Reference)
NIST Chemistry Reference
(S)-(+)-2-Amino-3-methyl-1-butanol(2026-48-4)
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Safety

Hazard Codes 
Xi
Risk Statements 
36-36/37/38
Safety Statements 
26-24/25-36
WGK Germany 
3
F 
10-23
HazardClass 
IRRITANT
HS Code 
29221980
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
186708
Product name
(S)-(+)-2-Amino-3-methyl-1-butanol
Purity
96%
Packaging
1g
Price
$54.3
Updated
2024/03/01
Sigma-Aldrich
Product number
186708
Product name
(S)-(+)-2-Amino-3-methyl-1-butanol
Purity
96%
Packaging
5g
Price
$88
Updated
2024/03/01
Sigma-Aldrich
Product number
8.14082
Product name
(S)-(+)-2-Amino-3-methyl-1-butanol
Purity
for synthesis
Packaging
1mL
Price
$12.3
Updated
2024/03/01
TCI Chemical
Product number
V0058
Product name
L-Valinol
Purity
>97.0%(GC)(T)
Packaging
5g
Price
$99
Updated
2024/03/01
TCI Chemical
Product number
V0058
Product name
L-Valinol
Purity
>97.0%(GC)(T)
Packaging
25g
Price
$297
Updated
2024/03/01
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(S)-(+)-2-Amino-3-methyl-1-butanol Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powde

Uses

L-Valinol is used as a reagent in the synthesis of simple 1,3-thiazolidine-2-thione derivatives which can exhibit fungicidal activity. L-Valinol is also used as a reagent in the synthesis of small-molecule inhibitors of MDM2-p53 protein-protein interaction (MDM2 inhibitors) in clinical trials for the treatment of cancer.

Uses

(S)-(+)-2-Amino-3-methyl-1-butanol can be used to prepare:

  • Imines and oxazolines by reacting with aldehydes and nitriles, respectively.
  • Chiral oxazoline derived multidentate ligands containing cyclophosphazene moiety.

Purification Methods

Purify S-valinol by vacuum distillation using a short Vigreux column (p 11). Alternatively it is purified by steam distillation. The steam distillate is acidified with HCl; the aqueous layer is collected and evaporated. The residue is dissolved in butan-1-ol, filtered and dry Et2O added to crystallise the hydrochloride salt (hygroscopic), m 113o. The free base can be obtained by suspending the salt in Et2O and adding small volumes of saturated aqueous K2CO3 until effervescence is complete and the mixture is distinctly alkaline. At this stage the aqueous layer should appear as a white sludge. The mixture is heated to boiling and refluxed for 30minutes (more Et2O is added if necessary). Purification of Biochemicals — Amino Acids and Peptides The Et2O layer is decanted off from the white sludge, the sludge is extracted twice with Et2O (by boiling for a few minutes), the combined organic layers are dried (KOH pellets), evaporated and the residue is distilled in a vacuum. [Nagao et al. J Org Chem 55 1148 1990, Beilstein 4 III 805.]

(S)-(+)-2-Amino-3-methyl-1-butanol Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-(+)-2-Amino-3-methyl-1-butanol Suppliers

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View Lastest Price from (S)-(+)-2-Amino-3-methyl-1-butanol manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
L-Val-OL 2026-48-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2024-01-20
Henan Fengda Chemical Co., Ltd
Product
(S)-(+)-2-Amino-3-methyl-1-butanol 2026-48-4
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-03-22
Henan Aochuang Chemical Co.,Ltd.
Product
(S)-(+)-2-Amino-3-methyl-1-butanol 2026-48-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-10-10

2026-48-4, (S)-(+)-2-Amino-3-methyl-1-butanolRelated Search:

3-Aminophenol Ketorolac tromethamine Fosfomycin tromethamine 3-Methyl-1-butanol 1-Butanol Glycine (R)-TERT-LEUCINOL Methylparaben Kresoxim-methyl VALINOMYCIN Bensulfuron methyl Methyl acrylate ALTRENOGEST 6-Aminocaproic acid tert-Butanol Thiophanate-methyl TRISTEARIN Dexketoprofen trometamol

  • L-VALINAL
  • (+)-L-VALINOL
  • L-(+)-VALINOL
  • L-VALINOL
  • L-2-AMINO-3-METHYL-1-BUTANOL
  • l-2-amino-3-methylbutan-1-ol
  • H-VALINOL
  • H-VAL-OL
  • H-L-VAL-OL
  • (2S)-2-AMINO-3-METHYL-BUTAN-1-OL
  • L-Valinol ,98%
  • (S)-2-Isopropyl-2-aminoethanol
  • (S)-(+)-2-Amino-3-methyl-1-butanol,96%
  • L-Valinol ,98% [ee: 95%]
  • L-Valinol ,95%
  • (S)-(+)-2-Amino-3-me
  • L-Valino
  • (S)-(+)-2-AMino-3-Methyl-1-butanol, 96% 1ML
  • (S)-(+)-2-AMINO-3-METHYL-1-BUTANOL FOR S
  • (S)-(+)-2-Amino-3-methyl-1-butanol(L-Valinal)
  • L-Valinol, 98%, ee: 95%
  • PKC PharMaceuticals, Inc.
  • L - valerian aMMonia alcohol
  • L-(+)-Valinol (S)-(+)-2-Amino-3-methyl-1-butanol L-2-Amino-3-methylbutan-1-ol
  • (S)-(+)-2-Amino-3-methyl-1-butanol 96%
  • L-Valinol Free Base
  • L-Valinol, ee: 95%
  • L-Valinol≥ 98% (GC)
  • L-Valinol,99%e.e.
  • L-Valinol,Elvitegravir intermediate
  • 1-Butanol, 2-amino-3-methyl-, (S)-
  • (S)-(+)-2-Amino-3-methyl-1-butanol~H-Val-ol
  • Valinol,97%
  • (R)-(+)-2-Amino-3-methyl-1-butanolL-Valanol
  • L-Valinol(S)-(+)-2-Amino-3-methyl-1-butanol
  • L-Valanol
  • (S)-(+)-2-AMINO-3-METHYL-1-BUTANOL, 96% (95% EE/GLC)
  • L-Val-ol
  • (S)-2-AMINO-3-METHYL-1-BUTANOL 98.0%
  • 1-Butanol, 2-amino-3-methyl-, (2S)-
  • S-VALINOL
  • (S)-2-AMINO-3-METHYL-L-BUTANOL
  • (S)-(+)-2-AMINO-3-METHYL-BUTANOL
  • (S)-2-AMINO-3-METHYL-BUTAN-1-OL
  • (S)-(+)-2-AMINO-3-METHYL-1-BUTANOL
  • (S)-2-AMINO-3-METHYL-1-BUTANOL
  • S-(-)-2-AMINO-3-METHYL-1-BUTANOL
  • H-Val-ol (S)-(+)-2-Amino-3-methyl-1-butanol)
  • -(+)-VaL
  • (S)-(+)-2-Amino-3-methyl-1-butanol USP/EP/BP
  • M0
  • AMG-232-008
  • (+)-Valinol
  • val-ol
  • L-2-Amino-3-methyl-1-butanol, L-Valinol
  • 2026-48-4
  • 2046-48-4
  • 226-48-4