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Dropropizine

Product Name
Dropropizine
CAS No.
17692-31-8
Chemical Name
Dropropizine
Synonyms
ribex;katril;larylin;catabex;UCB-196;ditustat;tussilex;gevotuss;UCB-1967;dopropizin
CBNumber
CB9328471
Molecular Formula
C13H20N2O2
Formula Weight
236.31
MOL File
17692-31-8.mol
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Dropropizine Property

Melting point:
105° (Morren); mp 108° (Bourdais)
Boiling point:
205 °C(Press: 1 Torr)
Density 
1.168±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Sparingly), Methanol (Slightly)
form 
Solid
pka
14.21±0.20(Predicted)
color 
White to Off-White
CAS DataBase Reference
17692-31-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36
WGK Germany 
3
RTECS 
TZ1074800
Toxicity
LD50 in rats (mg/kg): 200 i.v., 750 orally (Morren)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D4285
Product name
(±)-Dropropizine
Purity
analytical standard, for drug analysis
Packaging
5g
Price
$55.7
Updated
2022/05/15
TRC
Product number
D681495
Product name
racDropropizine
Packaging
1g
Price
$120
Updated
2021/12/16
AK Scientific
Product number
H962
Product name
Dropropizine
Packaging
5g
Price
$47
Updated
2021/12/16
AK Scientific
Product number
H962
Product name
Dropropizine
Packaging
100g
Price
$561
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0014296
Product name
DROPROPIZINE
Purity
95.00%
Packaging
1G
Price
$716.1
Updated
2021/12/16
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Dropropizine Chemical Properties,Usage,Production

Originator

Ribex,Formenti

Uses

antitussive

Uses

Dropropizine is a cough suppressant and central sedative therapeutic agent.

Definition

ChEBI: 3-(4-phenyl-1-piperazinyl)propane-1,2-diol is a member of piperazines.

Manufacturing Process

34 g 1,2-epoxy-3-hydroxypropane (glycide) in 50 ml of water were added to 64.8 g 1-phenylpiperazine in 80 ml of ethanol at the temperature not higher 50°C. The mixture was stood at night, then it was evaporated to dryness in vacuum and the stark product was recrystallized from 100 ml of acetone to give 60 g 1-phenyl-4-(2,3-dihydroxypropyl)piperazine (dropropizine) MP 105°C; BP 205°C/1 mm Hg.

Therapeutic Function

Antitussive

Dropropizine Preparation Products And Raw materials

Raw materials

p-Toluenesulfonic acid 1-Phenylpiperazine Ethanol Acetone Sodium sulfate Toluene 2,2-Dimethyl-1,3-dioxolane-4-methanol Sodium borohydride Chloroform Diethanolamine Tosyl chloride Zinc dichloride Hydrochloric acid D-Mannitol Methanol Sodium periodate 3-Chloro-1,2-propanediol Pyridine Phenylpiperazine

Preparation Products

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Dropropizine Suppliers

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LGM Pharma
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View Lastest Price from Dropropizine manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Dropropizine 17692-31-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Career Henan Chemical Co
Product
Dropropizine 17692-31-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2019-07-03

17692-31-8, DropropizineRelated Search:

PHENYL VALERATE 1-Methoxy-2-propyl acetate Hydroxypropyl methyl cellulose 2-Hydroxypropyl-β-cyclodextrin trans-1-Cinnamylpiperazine Diphenyl ether (R)-(-)-1,2-Propanediol Diprophylline 1-Methoxy-2-propanol Propylene glycol 1,3-Propanediol Poly(propylene glycol) Hydroxypropyl cellulose Hydroxypropyl acrylate PHENYL RESIN (S)-Dropropizine mociprazine Centpropazine

  • 3-(4-phenyl-1-piperazinyl)-2-propanediol
  • catabex
  • dipropizine
  • ditustat
  • dopropizin
  • katril
  • larylin
  • 1,2-PROPANEDIOL, 3-(4-PHENYL-1-PIPERAZINYL)-
  • 3-(4-phenylpiperazin-1-yl)propane-1,2-diol
  • 3-(4-Phenyl-1-piperazinyl)1,2-
  • ribex
  • tussilex
  • (+/-)-DROPROPIZINE
  • DROPROPIZINE
  • LABOTEST-BB LT00771927
  • 3-[4-PHENYL-1-PIPERAZINYL]-1,2-PROPANEDIOL
  • gevotuss
  • UCB-1967
  • 3-(4-Phenyl-1-piperazinyl)-1，2-pmpanediol
  • 3-(4-phenyl-1-piperazinyl)propane-1,2-diol
  • UCB-196
  • rac Dropropizine
  • Dropropizine ISO 9001：2015 REACH
  • (+-)-dropropizine
  • (?-Dropropizine
  • (±)-Dropropizine|||UCB-196|||UCB-1967
  • Dropropizine, 10 mM in DMSO
  • 17692-31-8
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