ChemicalBook > CAS DataBase List > 3-Chloropropiophenone
3-Chloropropiophenone
- Product Name
- 3-Chloropropiophenone
- CAS No.
- 936-59-4
- Chemical Name
- 3-Chloropropiophenone
- Synonyms
- 3-chloro-1-phenylpropan-1-one;3-CHLORO-1-PHENYL-1-PROPANONE;1-Propanone, 3-chloro-1-phenyl-;NSC 37238;NSC 227202;JACS-936-59-4;oropropiophenone;β-Chlorpropiophenon;á-chloropropiophenone;B-CHLOROPROPIOPHENONE
- CBNumber
- CB9332104
- Molecular Formula
- C9H9ClO
- Formula Weight
- 168.62
- MOL File
- 936-59-4.mol
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3-Chloropropiophenone Property
- Melting point:
- 48-50 °C(lit.)
- Boiling point:
- 113-115 °C4 mm Hg(lit.)
- Density
- 1.1115 (rough estimate)
- refractive index
- 1.5350 (estimate)
- Flash point:
- >230 °F
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- color
- Off-White to Pale Yellow
- Water Solubility
- Insoluble
- BRN
- 2043580
- Stability:
- Stable. Incompatible with strong bases, strong oxidizing agents.
- CAS DataBase Reference
- 936-59-4(CAS DataBase Reference)
- NIST Chemistry Reference
- 1-Propanone, 3-chloro-1-phenyl-(936-59-4)
- EPA Substance Registry System
- 1-Propanone, 3-chloro-1-phenyl- (936-59-4)
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Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 37/39-26-24/25
- WGK Germany
- 3
- TSCA
- Yes
- HS Code
- 29147000
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 335614
- Product name
- 3-Chloropropiophenone
- Purity
- 98%
- Packaging
- 10g
- Price
- $88.9
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- 335614
- Product name
- 3-Chloropropiophenone
- Purity
- 98%
- Packaging
- 50g
- Price
- $125.3
- Updated
- 2025/07/31
TCI Chemical
- Product number
- C0995
- Product name
- 3-Chloropropiophenone
- Purity
- >96.0%(GC)
- Packaging
- 25g
- Price
- $80
- Updated
- 2025/07/31
TRC
- Product number
- C379770
- Product name
- 3-Chloropropiophenone
- Packaging
- 50g
- Price
- $125
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 2617-5-X6
- Product name
- 3-Chloropropiophenone, technical grade
- Purity
- 90%
- Packaging
- 250g
- Price
- $96
- Updated
- 2021/12/16
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3-Chloropropiophenone Chemical Properties,Usage,Production
Description
3-Chloropropiophenone is a chiral compound that is used as an antidepressant drug. It was first synthesized in the 1950s and has been studied extensively for its pharmacological effects. It is a racemic mixture of two enantiomers, one of which is active and the other inactive. The active enantiomer binds to serotonin receptors and inhibits the reuptake of serotonin, which leads to an increase in serotonin levels. The inactive enantiomer does not bind to serotonin receptors and does not inhibit the reuptake of serotonin. 3-Chloropropiophenone has been shown to be effective when administered at an optimum concentration of 5 milligrams per kilogram body weight.
Chemical Properties
faintly yellow to tan crystalline powder
Uses
3-Chloropropiophenone is an Impurity of Fluoxetine (F597100).
Uses
3-Chloropropiophenone was used in the asymmetric reduction of (S)-3-chloro-1-phenylpropanol using preheated Candida utilis cells immobilized in calcium alginate gel beads. It was also used in the synthesis of (R)-3-chloro-1-phenyl-1-propanol via asymmetric reduction using in-situ generated oxazaborolidine catalyst derived from (S)-α,α-diphenylprolinol. It is a precursor of phenyl vinyl ketone.
Synthesis
Adding 3' -chlorobenzene acetone and levorotatory prolinol into 95% ethanol and stirring; cooling after the reaction liquid is wholly dissolved; adding potassium borohydride into the reaction solution in batches, and preserving heat after adding; heating the reaction solution for reflux reaction, and concentrating the reaction solution under reduced pressure; adding n-hexane into the reaction solution, heating, and adding active carbon for heat preservation and decoloration; filtering the reaction solution, leaching a filter cake by using normal hexane, and collecting filtrate; crystallizing and filtering the filtrate, leaching the filter cake once with n-hexane, and drying in vacuum to obtain 3-Chloropropiophenone.
References
[1] Synlett, 2016, vol. 27, # 5, p. 789 - 793
[2] Journal of Organic Chemistry USSR (English Translation), 1969, vol. 5, p. 323 - 326
[3] Zhurnal Organicheskoi Khimii, 1969, vol. 5, # 2, p. 337 - 340
3-Chloropropiophenone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Chloropropiophenone manufacturers
RongNa Biotechnology Co.,Ltd
- Product
- 3-Chloropropiophenone 936-59-4
- Price
- US $10.00/ASSAYS
- Min. Order
- 1ASSAYS
- Purity
- 99%
- Supply Ability
- 1 ton
- Release date
- 2025-08-28
Hebei Chuanghai Biotechnology Co., Ltd
- Product
- 3-Chloropropiophenone 936-59-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-12-04
Hubei Lidu New Material Technology Co., Ltd
- Product
- 3-Chloropropiophenone 936-59-4
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 20TON
- Release date
- 2024-12-11
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