3-Chloropropiophenone

Product Name: 3-Chloropropiophenone
CAS No.: 936-59-4
Chemical Name: 3-Chloropropiophenone
Synonyms: 3-chloro-1-phenylpropan-1-one;3-CHLORO-1-PHENYL-1-PROPANONE;1-Propanone, 3-chloro-1-phenyl-;NSC 37238;NSC 227202;JACS-936-59-4;oropropiophenone;β-Chlorpropiophenon;á-chloropropiophenone;B-CHLOROPROPIOPHENONE
CBNumber: CB9332104
Molecular Formula: C9H9ClO
Formula Weight: 168.62
MOL File: 936-59-4.mol

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3-Chloropropiophenone Property

Melting point:: 48-50 °C(lit.)
Boiling point:: 113-115 °C4 mm Hg(lit.)
Density: 1.1115 (rough estimate)
refractive index: 1.5350 (estimate)
Flash point:: >230 °F
storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
color: Off-White to Pale Yellow
Water Solubility: Insoluble
BRN: 2043580
Stability:: Stable. Incompatible with strong bases, strong oxidizing agents.
CAS DataBase Reference: 936-59-4(CAS DataBase Reference)
NIST Chemistry Reference: 1-Propanone, 3-chloro-1-phenyl-(936-59-4)
EPA Substance Registry System: 1-Propanone, 3-chloro-1-phenyl- (936-59-4)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 37/39-26-24/25
WGK Germany: 3
TSCA: Yes
HS Code: 29147000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 335614
Product name: 3-Chloropropiophenone
Purity: 98%
Packaging: 50g
Price: $69.6
Updated: 2024/03/01

Sigma-Aldrich

Product number: 335614
Product name: 3-Chloropropiophenone
Purity: 98%
Packaging: 10g
Price: $86.2
Updated: 2024/03/01

TCI Chemical

Product number: C0995
Product name: 3-Chloropropiophenone
Purity: >96.0%(GC)
Packaging: 25g
Price: $80
Updated: 2024/03/01

Alfa Aesar

Product number: A12290
Product name: 3-Chloropropiophenone, 96%
Packaging: 10g
Price: $44.65
Updated: 2024/03/01

Alfa Aesar

Product number: A12290
Product name: 3-Chloropropiophenone, 96%
Packaging: 50g
Price: $150.65
Updated: 2024/03/01

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3-Chloropropiophenone Chemical Properties,Usage,Production

Description

3-Chloropropiophenone is a chiral compound that is used as an antidepressant drug. It was first synthesized in the 1950s and has been studied extensively for its pharmacological effects. It is a racemic mixture of two enantiomers, one of which is active and the other inactive. The active enantiomer binds to serotonin receptors and inhibits the reuptake of serotonin, which leads to an increase in serotonin levels. The inactive enantiomer does not bind to serotonin receptors and does not inhibit the reuptake of serotonin. 3-Chloropropiophenone has been shown to be effective when administered at an optimum concentration of 5 milligrams per kilogram body weight.

Chemical Properties

faintly yellow to tan crystalline powder

Uses

3-Chloropropiophenone is an Impurity of Fluoxetine (F597100).

Uses

3-Chloropropiophenone was used in the asymmetric reduction of (S)-3-chloro-1-phenylpropanol using preheated Candida utilis cells immobilized in calcium alginate gel beads. It was also used in the synthesis of (R)-3-chloro-1-phenyl-1-propanol via asymmetric reduction using in-situ generated oxazaborolidine catalyst derived from (S)-α,α-diphenylprolinol. It is a precursor of phenyl vinyl ketone.

Synthesis

Adding 3' -chlorobenzene acetone and levorotatory prolinol into 95% ethanol and stirring; cooling after the reaction liquid is wholly dissolved; adding potassium borohydride into the reaction solution in batches, and preserving heat after adding; heating the reaction solution for reflux reaction, and concentrating the reaction solution under reduced pressure; adding n-hexane into the reaction solution, heating, and adding active carbon for heat preservation and decoloration; filtering the reaction solution, leaching a filter cake by using normal hexane, and collecting filtrate; crystallizing and filtering the filtrate, leaching the filter cake once with n-hexane, and drying in vacuum to obtain 3-Chloropropiophenone.

3-Chloropropiophenone Preparation Products And Raw materials

Raw materials

Preparation Products

Bathophenanthroline

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3-Chloropropiophenone Suppliers

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View Lastest Price from 3-Chloropropiophenone manufacturers

shandong perfect biotechnology co.ltd

Product: 3-Chloropropiophenone 936-59-4
Price: US $0.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 1kg
Release date: 2024-01-05

.GZ HONESTCHEM CO.,LTD

Product: 3-Chloropropiophenone 936-59-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99.9%
Supply Ability: 500KG
Release date: 2021-07-02

Hebei Chuanghai Biotechnology Co,.LTD

Product: 3-Chloropropiophenone 936-59-4
Price: US $10.70/KG
Min. Order: 10KG
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-20

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ClCH2CH2COC6H5

C9H9CIO

KETONE

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C9

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Chemical Synthesis