ISOQUINOLINE-5-CARBALDEHYDE

Product Name: ISOQUINOLINE-5-CARBALDEHYDE
CAS No.: 80278-67-7
Chemical Name: ISOQUINOLINE-5-CARBALDEHYDE
Synonyms: CHEMBRDG-BB 4301909;RARECHEM AK ML 0044;5-Formyl isoquinoline;5-ISOQUINOLINECARBALDEHYDE;ISOQUINOLINE-5-CARBALDEHYDE;5-isoquinolinecarboxaldehyde;ISOQUINOLINE-5-CARBOXALDEHYDE;Isoquinoline-5-carbaldehyde ,98%;Isoquinoline-5-carboxaldehyde,97%;Isoquinoline-5-carboxaldehyde 96%
CBNumber: CB9333444
Molecular Formula: C10H7NO
Formula Weight: 157.17
MOL File: 80278-67-7.mol

More

Less

ISOQUINOLINE-5-CARBALDEHYDE Property

Melting point:: 116-120 °C
Boiling point:: 331.7±15.0 °C(Predicted)
Density: 1.223±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: powder to crystal
pka: 4.53±0.13(Predicted)
color: White to Light yellow
Sensitive: Air Sensitive
BRN: 112875
InChI: InChI=1S/C10H7NO/c12-7-9-3-1-2-8-6-11-5-4-10(8)9/h1-7H
InChIKey: ILRSABOCKMOFGW-UHFFFAOYSA-N
SMILES: C1C2=C(C(C=O)=CC=C2)C=CN=1
CAS DataBase Reference: 80278-67-7(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xn
Risk Statements: 36/37/38-36-22
Safety Statements: 26-36
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29334900

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 675180
Product name: Isoquinoline-5-carboxaldehyde
Purity: 96%
Packaging: 1g
Price: $90.6
Updated: 2023/06/20

TCI Chemical

Product number: I0942
Product name: Isoquinoline-5-carboxaldehyde
Purity: >98.0%(GC)
Packaging: 1g
Price: $155
Updated: 2025/07/31

TCI Chemical

Product number: I0942
Product name: Isoquinoline-5-carboxaldehyde
Purity: >98.0%(GC)
Packaging: 5g
Price: $618
Updated: 2025/07/31

TRC

Product number: I809018
Product name: Isoquinoline-5-carbaldehyde
Packaging: 100mg
Price: $75
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H15-1-J5
Product name: Isoquinoline-5-carboxaldehyde
Packaging: 1g
Price: $76
Updated: 2021/12/16

More

Less

ISOQUINOLINE-5-CARBALDEHYDE Chemical Properties,Usage,Production

Chemical Properties

Yellow to light brown powder

Uses

Direct conversion of heteroaryl-carboxaldehydes to acetonitriles by treatment with cyanoethylphosphonate followed by samarium(II) iodide reduction.

Synthesis

34784-04-8

68-12-2

80278-67-7

To a solvent mixture of ether (80 mL) and tetrahydrofuran (80 mL), n-butyllithium (19.3 mL, 2.5 M hexane solution, 48 mmol) was slowly added dropwise at -78 °C. Subsequently, a solution of 5-bromoisoquinoline (5.0 g, 24 mmol) in tetrahydrofuran (10 mL) was added dropwise. The reaction mixture was stirred at -78 °C and under argon protection for 30 min. Referring to the method of Pearson et al. in Journal of Heterocyclic Chemistry, Vol. 6, No. 2, pp. 243-245 (1969), a tetrahydrofuran (10 mL) solution of N,N-dimethylformamide (3.30 g, 45 mmol) was rapidly added to the lithium isoquinolinium solution after it was cooled to -78°C. The mixture was continued to be stirred at -78 °C for 15 minutes. Subsequently, ethanol (20 mL) and saturated ammonium chloride solution were added. The resulting suspension was slowly warmed to room temperature. The organic and ether extracted layers were combined and dried with anhydrous sodium sulfate. Purification by silica gel column chromatography (SiO2-H, hexane solution of 50% ethyl acetate) and ethanol recrystallization afforded isoquinoline-5-carbaldehyde (2.4 g, 15 mmol, 64% yield) as a light yellow solid with a melting point of 114-116 °C.1H NMR (DMSO-d6) δ 10.40 (s, 1H), 9.44 (s, 1H), 8.85 (d 1H, J = 6.0 Hz), 8.69 (d, 1H, J = 6.0 Hz), 8.45 (m, 2H), 7.90 (t, 1H, J = 7.2 Hz); 13C NMR (DMSO-d6) δ 194.23, 153.5, 146.2, 140.2, 135.2, 132.6, 130.2, 128.6, 127.5, 117.2. Calculated elemental values (C10H7NO-0.05H2O): C, 75.99; H, 4.53; N, 8.86. Measured values: C, 75.98; H, 4.66; N, 8.68.

References

[1] Journal of Medicinal Chemistry, 2002, vol. 45, # 17, p. 3660 - 3668
[2] Patent: US2007/155720, 2007, A1. Location in patent: Page/Page column 24

ISOQUINOLINE-5-CARBALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

ISOQUINOLINE-5-CARBALDEHYDE Suppliers

Americas 1 Belgium 1 China 109 Europe 4 France 2 Germany 6 India 7 Japan 1 Switzerland 1 The Netherlands 1 United Kingdom 11 United States 35 Global 179

Ark Pharm, Inc.

Tel: 847-367-3680
Fax: 847-367-3681
Email: sales@arkpharminc.com
Country: United States
ProdList: 1670
Advantage: 56

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 52923
Advantage: 58

Sphinx Scientific Laboratory, LLC

Tel: --
Fax: --
Email: sales@sphinxscientificlab.com
Country: United States
ProdList: 3343
Advantage: 50

Chem-Impex International, Inc. (CII)

Tel: --
Fax: --
Email: Customer@chemimpex.com
Country: United States
ProdList: 893
Advantage: 58

Combi-Blocks, Inc.

Tel: --
Fax: --
Email: les@combi-blocks.com
Country: United States
ProdList: 2555
Advantage: 58

MilliporeSigma (Sigma-Aldrich Corp.)

Tel: --
Fax: --
Email: @sial.com
Country: United States
ProdList: 5414
Advantage: 58

2A Biotech USA

Tel: --
Fax: --
Email: info@2abiotech.com
Country: United States
ProdList: 1785
Advantage: 58

Fluorochem Ltd.

Tel: --
Fax: --
Email: enquiries@fluorochem.co.uk
Country: United States
ProdList: 4583
Advantage: 58

VWR International, LLC.

Tel: --
Fax: --
Email: @sargentwelch.com
Country: United States
ProdList: 6262
Advantage: 58

Alichem Inc.

Tel: --
Fax: --
Email: sales@alichem.com
Country: United States
ProdList: 6167
Advantage: 58

Crescent Chemical Company

Tel: --
Fax: --
Email: fran@creschem.com
Country: United States
ProdList: 1441
Advantage: 58

Oakwood Products, Inc.

Tel: --
Fax: --
Email: sales@oakwoodchemical.com
Country: United States
ProdList: 6193
Advantage: 74

OChem Incorporation

Tel: --
Fax: --
Email: sales@ocheminc.com
Country: United States
ProdList: 6501
Advantage: 60

AK Scientific, Inc.

Tel: --
Fax: --
Email: sales@aksci.com
Country: United States
ProdList: 6347
Advantage: 65

SynChem，Inc

Tel: --
Fax: --
Email: sales@synchem.com
Country: United States
ProdList: 4697
Advantage: 58

SynQuest Laboratories, Inc.

Tel: --
Fax: --
Email: info@synquestlabs.com
Country: United States
ProdList: 6871
Advantage: 62

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

TCI America

Tel: --
Fax: --
Email: sales@tciamerica.com
Country: United States
ProdList: 6909
Advantage: 75

Frontier Scientific, Inc.

Tel: --
Fax: --
Email: sales@frontiersci.com
Country: United States
ProdList: 6222
Advantage: 86

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

Synthonix

Tel: --
Fax: --
Email: info@synthonix.com
Country: United States
ProdList: 1423
Advantage: 68

Synchem Inc.

Tel: --
Fax: --
Email: catalog@synchem.com
Country: United States
ProdList: 1154
Advantage: 46

Gainbiotech, LLC

Tel: --
Fax: --
Email: sales@gainbiotech.com
Country: United States
ProdList: 616
Advantage: 0

Anvia Chemicals, LLC

Tel: --
Fax: --
Email: sales@anviachem.com
Country: United States
ProdList: 3933
Advantage: 0

AOBChem USA

Tel: --
Fax: --
Email: sales@aobchem.com
Country: United States
ProdList: 3487
Advantage: 50

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6962
Advantage: 56

Alfa Aesar

Tel: --
Fax: --
Email: tech@alfa.com
Country: United States
ProdList: 6814
Advantage: 81

Chem-Impex International, Inc.

Tel: --
Fax: --
Country: United States
ProdList: 6730
Advantage: 64

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

Anichem LLC

Tel: --
Fax: --
Email: sales@anichemllc.com
Country: United States
ProdList: 4112
Advantage: 34

Pharmabridge Inc.

Tel: --
Fax: --
Email: sales@pharmabridgegroup.com
Country: United States
ProdList: 731
Advantage: 55

ChemBridge Corporation

Tel: --
Fax: --
Email: resupply@chembridge.com
Country: United States
ProdList: 6648
Advantage: 70

Beta Pharma, Inc.

Tel: --
Fax: --
Email: sales@betapharma.com
Country: United States
ProdList: 6226
Advantage: 60

J & W PharmLab, LLC

Tel: --
Fax: --
Email: services@jwpharmlab.com
Country: United States
ProdList: 4156
Advantage: 63

More

Less

View Lastest Price from ISOQUINOLINE-5-CARBALDEHYDE manufacturers

Career Henan Chemical Co

Product: ISOQUINOLINE-5-CARBALDEHYDE 80278-67-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-25

80278-67-7, ISOQUINOLINE-5-CARBALDEHYDERelated Search:

Isoquinoline-3-carbaldehyde ISOQUINOLINE-5-CARBOXYLIC ACID ISOQUINOLINE-1-CARBALDEHYDE ISOQUINOLINE-8-CARBALDEHYDE ISOQUINOLINE-4-CARBALDEHYDE 1-ISOQUINOLINEMETHANOL 6-Isoquinolinecarboxaldehyde (9CI) 6-Isoquinolinyl-boronic acid Isoquinoline-3-carboxylic acid 8-isoquinolinyl-boronic acid C-ISOQUINOLIN-4-YL-METHYLAMINE 7-Isoquinolinecarboxaldehyde (6CI,9CI) ISOQUINOLINE N-OXIDE 8-Isoquinolinecarbonitrile(9CI) ISOQUINOLINE-1-CARBOXYLIC ACID METHYL ESTER ETHYL ISOQUINOLINE-3-CARBOXYLATE p-[2-(3,4-dihydro-7-methoxy-4,4-dimethyl-1,3-dioxo-2(1H)-isoquinolyl)ethyl]benzenesulphonamide 7-isoquinolinecarboxylic acid

5-Formyl isoquinoline

RARECHEM AK ML 0044

CHEMBRDG-BB 4301909

ISOQUINOLINE-5-CARBOXALDEHYDE

ISOQUINOLINE-5-CARBALDEHYDE

Isoquinoline-5-carboxaldehyde,97%

5-Isoquinolinecarboxaldehyde (6CI,9CI)

5-isoquinolinecarboxaldehyde

5-Formylisoquinoline, 5-Formyl-2-azanaphthalene

Isoquinoline-5-carbaldehyde ,98%

isoquinoline-5-carbaldehyde(SALTDATA: FREE)

5-ISOQUINOLINECARBALDEHYDE

Isoquinoline-5-carboxaldehyde 96%

Isoquinoline-5-carboxaldehyde &gt

ISOQUINOLINE-5-CARBALDEHYDE ISO 9001：2015 REACH

80278-67-7

Building Blocks

Isoquinolines

Heterocyclic Building Blocks

Building Blocks

Heterocyclic Building Blocks

Isoquinolines

Isoquinoline Derivertives

ALDEHYDE

Building Blocks

Isoquinoline