ChemicalBook > CAS DataBase List > BAY 299

BAY 299

Product Name: BAY 299
CAS No.: 2080306-23-4
Chemical Name: BAY 299
Synonyms: CPD1617;BAY 299;BAY-299, 10 mM in DMSO;BAY-299; BAY 299; BAY299;BAY-299, TAF1 and BRD1 inhibitor;6-(3-hydroxypropyl)-2-(1,3,6-trimethyl-2-oxobenzimidazol-5-yl)benzo[de]isoquinoline-1,3-dione;6-(3-Hydroxy-propyl)-2-(1,3,6-trimethyl-2-oxo-2,3-dihydro-1H-benzoimidazol-5-yl)-benzo[de]isoquinoline-1,3-dione;6-(3-Hydroxypropyl)-2-(1,3,6-trimethyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)-1H-benzo[de]isoquinoline-1,3(2H)-dione;1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,3-dihydro-1,3,6-trimethyl-2-oxo-1H-benzimidazol-5-yl)-6-(3-hydroxypropyl)-;6-(3-Hydroxypropyl)-2-(1,3,6-trimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-1H-benzo[de]isoquinoline-1,3(2H)-dione
CBNumber: CB93381026
Molecular Formula: C25H23N3O4
Formula Weight: 429.47
MOL File: 2080306-23-4.mol

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BAY 299 Property

Boiling point:: 688.7±55.0 °C(Predicted)
Density: 1.377±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:30.0(Max Conc. mg/mL);69.85(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);69.85(Max Conc. mM)
form: A crystalline solid
pka: 14.98±0.10(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1756
Product name: BAY-299
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $112
Updated: 2025/07/31

Cayman Chemical

Product number: 19777
Product name: BAY-299
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 19777
Product name: BAY-299
Purity: ≥98%
Packaging: 5mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 19777
Product name: BAY-299
Purity: ≥98%
Packaging: 10mg
Price: $169
Updated: 2024/03/01

Cayman Chemical

Product number: 19777
Product name: BAY-299
Purity: ≥98%
Packaging: 25mg
Price: $381
Updated: 2024/03/01

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BAY 299 Chemical Properties,Usage,Production

Description

BAY-299 is a potent and selective inhibitor of the bromodomain and PHD finger-containing (BRPF) family protein BRD1 (IC₅₀ = 6 nM), also known as BRPF2, and the second bromodomain of transcription initiation factor TFIID subunits 1 (TAF1; IC₅₀ = 13 nM). BAY-299 is >30-fold selective over BRPF1, BRPF3, BRD9, and ATAD2 and is >300-fold selective over BRD4. See the Structural Genomics Consortium (SGC) website for more information.

Uses

BAY 299, is a potent and selective inhibitor of the bromodomain and PHD finger-containing (BRPF) family protein BRD1, also known as BRPF2, and a strong inhibitor of TAF1/TAF1L BD2. These proteins play important roles in transcription regulation.

in vivo

Studies of the in vivo pharmacokinetic properties of BAY-299 in rat reveal that blood clearance is low (ca. 17% of hepatic blood flow), volume of distribution in steady-state high, terminal half-life long to very long (t_1/2=10 h), and bioavailability high (F=73%). In vivo blood clearance is as anticipated based on rat liver microsome values but lower than expected based on hepatocyte data^[1].

IC 50

BRPF2 BD: 67 nM (IC₅₀); BRPF1 BD: 3150 nM (IC₅₀); BRPF3 BD: 5550 nM (IC₅₀); TAF1 BD2: 8 nM (IC₅₀); TAF1L BD2: 106 nM (IC₅₀)

storage

Store at -20°C

References

[1] MONTSERRAT PéREZ-SALVIA M E. Bromodomain inhibitors and cancer therapy: From structures to applications[J]. Epigenetics, 2016, 12 1: 323-339. DOI: 10.1080/15592294.2016.1265710

BAY 299 Preparation Products And Raw materials

Raw materials

Preparation Products

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2080306-23-4, BAY 299Related Search:

T-26c AZD-7594 4-[4-(1-methyl-1H-pyrazol-4-yl)-1-[2-(1-methyl-1H-pyrazol-4-yl)ethyl]-1H-imidazol-5-yl]-benzonitrile ABBV-744 Zofluza intermediate RGX-104 HCl Adavivint

BAY-299; BAY 299; BAY299

6-(3-hydroxypropyl)-2-(1,3,6-trimethyl-2-oxobenzimidazol-5-yl)benzo[de]isoquinoline-1,3-dione

BAY 299

CPD1617

6-(3-Hydroxypropyl)-2-(1,3,6-trimethyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)-1H-benzo[de]isoquinoline-1,3(2H)-dione

1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,3-dihydro-1,3,6-trimethyl-2-oxo-1H-benzimidazol-5-yl)-6-(3-hydroxypropyl)-

6-(3-Hydroxy-propyl)-2-(1,3,6-trimethyl-2-oxo-2,3-dihydro-1H-benzoimidazol-5-yl)-benzo[de]isoquinoline-1,3-dione

6-(3-Hydroxypropyl)-2-(1,3,6-trimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-1H-benzo[de]isoquinoline-1,3(2H)-dione

8-(3-hydroxypropyl)-3-(1,3,6-trimethyl-2-oxo-2,3-dihydro-1H-1,3-benzodiazol-5-yl)-3-azatricyclo[7.3.1.0?,13]trideca-1(13),5,7,9,11-pentaene-2,4-dione

BAY-299, TAF1 and BRD1 inhibitor

BAY-299, 10 mM in DMSO

2080306-23-4