ChemicalBook > CAS DataBase List > Moexipril

Moexipril

Product Name
Moexipril
CAS No.
103775-10-6
Chemical Name
Moexipril
Synonyms
MOEXIPRIL;MoexiprilC27H34N207;Moexipril USP/EP/BP;Moexiv hydrochloride;2-[2-[(1-ethoxycarbonyl-3-phenyl-propyl)amino]propanoyl]-6,7-dimethoxy-3,4-dihydro-1h-isoquinoline-3-carboxylic acid;(3S)-2-{N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl}-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid;(3S)-2-[(2S)-2-[[(1S)-1-carbethoxy-3-phenyl-propyl]amino]propanoyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-3-carboxylic acid;(3S)-2-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-3-carboxylic acid;(3S)-2-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenyl-butan-2-yl]amino]propanoyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-3-carboxylic acid;(3R)-2-[(2S)-2-[[(2R)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-1-oxopropyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-3-carboxylic acid
CBNumber
CB9338696
Molecular Formula
C27H34N2O7
Formula Weight
498.57
MOL File
103775-10-6.mol
More
Less

Moexipril Property

Boiling point:
709.3±60.0 °C(Predicted)
Density 
1?+-.0.06 g/cm3(Predicted)
pka
2.94±0.20(Predicted)
CAS DataBase Reference
103775-10-6(CAS DataBase Reference)
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Medical Isotopes, Inc.
Product number
D34068
Product name
Moexipril-d3HCl
Packaging
1mg
Price
$670
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0077244
Product name
MOEXIPRIL
Purity
95.00%
Packaging
100MG
Price
$757.97
Updated
2021/12/16
More
Less

Moexipril Chemical Properties,Usage,Production

Originator

Moexipril,Schwarz Pharma,Germany

Uses

Antihypertensive; enzyme inhibitor (angiotensinconverting).

Definition

ChEBI: Moexipril is a peptide.

Manufacturing Process

1) A solution of 2.0 g of t-butyl alanine (S-form) and 3.78 g of ethyl 2-bromo- 4-phenylbutanoate in 25 ml of DMF was treated with 1.8 ml of triethylamine and the solution was heated at 70°C for 18 hours. The solvent was removed at reduced pressure and the residue was mixed with water and extracted with ethyl ether. The organic layer was washed with water and dried over magnesium sulfate. Concentration of the solvent at reduced pressure gave the oily ethyl-α-[(1-carboxyethyl)amino]benzene-t-butanoate.
A solution of 143.7 g of this t-butyl ester in 630 ml of trifluoroacetic acid was stirred at room temperature for one hour. The solvent was removed at reduced pressure and the residue was dissolved in ethyl ether and again evaporated. This operation was repeated. Then the ether solution was treated dropwise with a solution of hydrogen chloride gas in ethyl ether until precipitation ceased. The solid, collected by filtration, was a mixture of diastereoisomers of ethyl-α-[(1-carboxyethyl)amino]benzenebutanoate hydrochloride, melting point 153-165°C; [α]D23 = +3.6° (1% MeOH).
The free amino acid (S,S-form) was prepared by treatment of an aqueous solution of the hydrochloride with saturated sodium acetate. The product was filtered, washed efficiently with cold water and recrystallized from ethyl acetate; melting point 149-151°C; [α]D23 = +29.7°.
2) A stirred solution of 0.0158 mole of ethyl-α-[(1-carboxyethyl)amino] benzenebutanoate hydrochloride in 200 ml of methylene chloride was treated successively with 1.60 g (0.0158 mole) of triethylamine, 0.0158 mole of 1- hydroxybenzotriazole, 0.0158 mole of 1,2,3,4-tetrahydro-6,7-dimethoxy-3- isoquinolinecarboxylic acid and then with 0.0158 mole of dicyclohexylcarbodiimide in 10 ml of methylene dichloride. Dicyclohexylurea gradually separated. The mixture was allowed to stand at room temperature overnight. Hexane (300 ml) was added and the urea was filtered. The filtrate was washed with 250 ml of saturated sodium bicarbonate, dried over sodium sulfate and concentrated to remove solvent. The viscous residue was triturated with 50 ml of ether and filtered to remove insolubles. The filtrate was concentrated to give 2-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1- oxopropyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-3-isoquinolinecarboxylic acid.
After addition of hydrochloric acid was obtained 2-[2-[[1-(ethoxycarbonyl)-3- phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-3- isoquinolinecarboxylic acid, hydrochloride.

brand name

Univasc (Schwarz Pharma).

Therapeutic Function

Antihypertensive

Moexipril Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Moexipril Suppliers

Canada 2 China 52 Europe 2 Germany 1 India 3 Japan 1 United Kingdom 7 United States 15 Global 83
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18207
Advantage
66
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9510
Advantage
66
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
Advantage
57
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
9387
Advantage
52
Wuhan Haizheng Industry & Trade Development Co. Ltd
Tel
027-8866 0053/88660577/88660578
Fax
027-8899 1911
Country
China
ProdList
1073
Advantage
55
Wuhan Dahua Pharmaceutical Co., Ltd.
Tel
027-59262863 13277907145 3091977954
Fax
027-59420980
Country
China
ProdList
4943
Advantage
58
Shanghai ACT chemical Limited
Tel
021-59904146 18001826933
Fax
+86-21-59904146
Email
sales@actchemical.com
Country
China
ProdList
476
Advantage
56
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Lynnchem
Tel
86-(0)29-85992781 17792393971
Email
info@lynnchem.com
Country
China
ProdList
4587
Advantage
58
Capot Chemical Co.,Ltd.
Tel
+86-（0）57185586718 +86-13336195806
Fax
+86-571-85864795
Email
sales@capot.com
Country
China
ProdList
29792
Advantage
60
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57423
Advantage
58
Hefei Molake Biotechnology Co., Ltd.
Tel
0551-66336380 18956014586
Fax
055166336380
Email
983438788@qq.com
Country
China
ProdList
2160
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
+86-0551-65418684 +8618949823763
Fax
0086-551-65418684
Email
sales@tnjchem.com
Country
China
ProdList
25356
Advantage
58
AFINE CHEMICALS LIMITED
Tel
+86-0571-85134551
Fax
008657185134895
Email
sales@afinechem.com
Country
China
ProdList
15352
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
+86-029-89586680 +86-18192503167
Fax
+86-29-88380327
Email
1026@dideu.com
Country
China
ProdList
7724
Advantage
58
Hubei Jusheng Technology Co.,Ltd.
Tel
18871490254
Fax
027-59599243
Email
linda@hubeijusheng.com
Country
CHINA
ProdList
28172
Advantage
58
CONIER CHEM AND PHARMA LIMITED
Tel
+8618523575427
Email
sales@conier.com
Country
China
ProdList
49476
Advantage
58
career henan chemical co
Tel
+86-0371-86658258 +8613203830695
Fax
0086-371-86658258
Email
factory@coreychem.com
Country
China
ProdList
29809
Advantage
58
Jiaxing Hengrui Biotechnology Co. LTD
Tel
0573-0573-82672231 13757365595
Fax
QQ：715584339
Email
regen_chemical1@163.com
Country
China
ProdList
4952
Advantage
58
Henan Jiuke Chemical Co. LTD
Tel
0370-2071226 17303700913
Fax
0370-2071226
Email
954866649@qq.com
Country
China
ProdList
2982
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24644
Advantage
58
Jikang Chemical Industry Co. , Ltd.
Tel
0573-057385609002 13355836373
Email
zhejia01@163.com
Country
China
ProdList
7868
Advantage
58
Shanghai isotope chemical co.,ltd
Tel
021-021-51600108 13062666369
Email
sales@chinaisotope.com
Country
China
ProdList
4271
Advantage
58
Shaanxi Xihua Chemical Industry Co., Ltd
Tel
029-81123119 15529505138
Email
1021@dideu.com
Country
China
ProdList
9983
Advantage
58
Shanghai Beiwanta Biotechnology Co., Ltd.
Tel
021-67187366 19901745723
Email
info@bwtlab.com
Country
China
ProdList
9376
Advantage
58
XIAMEN AMITY INDUSTRY AND TRADE CO., LTD.
Tel
+8618950047208
Email
ellena@amitychem.com
Country
China
ProdList
43416
Advantage
58
GIHI CHEMICALS CO.,LIMITED
Tel
+8618058761490
Email
info@gihichemicals.com
Country
China
ProdList
49982
Advantage
58
Absin Bioscience Inc.
Tel
--
Fax
--
Email
chenjw@absin.cn
Country
CHINA
ProdList
6705
Advantage
58
Shanghai Kuan Hao Gong Mao Co., Ltd.
Tel
--
Fax
--
Email
shkuanhao@163.com
Country
China
ProdList
106
Advantage
38
Shanghai trial of a chemical reagents Ltd.
Tel
--
Fax
--
Email
shkuanhao@163.com
Country
China
ProdList
110
Advantage
38
Trademax Pharmaceuticals & Chemicals Co., Ltd
Tel
--
Fax
--
Email
trademax@trademaxchem.com
Country
China
ProdList
205
Advantage
61
Carbosynth China Ltd.
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
China
ProdList
6532
Advantage
50
Si Yi Chem-Pharm Co., Ltd
Tel
--
Fax
--
Email
sales@chemwd.com
Country
China
ProdList
47
Advantage
34
Hangzhou Starshine Pharmaceutical Co., Ltd
Tel
--
Fax
--
Email
sales@starshinepharm.com
Country
China
ProdList
237
Advantage
47
Chongqing Nansong Chemi-Tech Ltd
Tel
--
Fax
--
Email
hohome@chemi-tech.com
Country
China
ProdList
51
Advantage
42
Longchem Co.,Limited
Tel
--
Fax
--
Email
sales@longchemcorp.com
Country
China
ProdList
138
Advantage
38
Shanghai Sochem International Co., Ltd
Tel
--
Fax
--
Email
sochem@163.net
Country
China
ProdList
896
Advantage
39
Lanospharma Laboratories Co.,Ltd
Tel
--
Fax
--
Email
sales@lanospharma.com
Country
China
ProdList
6329
Advantage
56
HANGZHOU FST PHARMACEUTICAL CO., LTD.
Tel
--
Fax
--
Email
sales@fstchem.com
Country
China
ProdList
65
Advantage
30
Kinbester Co., Ltd
Tel
--
Fax
--
Email
wjj@kinbester.com
Country
China
ProdList
4351
Advantage
58
Shanghai PI Chemicals Ltd.
Tel
--
Fax
--
Email
sales@pipharm.com
Country
China
ProdList
6344
Advantage
56
A.T.CHEMICAL
Tel
--
Fax
--
Email
Jeffreyxu@atchem.net
Country
China
ProdList
6589
Advantage
51
Yick-Vic Chemicals & Pharmaceuticals (HK) Ltd
Tel
--
Fax
--
Email
sales@yickvic.com
Country
China
ProdList
6206
Advantage
58
SUNWELL CHEMICALS CO.,LTD.(INTERPHARMA TRADING CO.,LIMITED.)
Tel
--
Fax
--
Email
sales@sunwell-chem.com
Country
China
ProdList
628
Advantage
47
AndaChem, Inc.
Tel
--
Fax
--
Email
sales@andachem.com
Country
China
ProdList
3357
Advantage
38
Advanced Technology & Industrial Co., Ltd.
Tel
--
Fax
--
Email
sales@advtechind.com
Country
China
ProdList
6523
Advantage
75
Leawell International Limited
Tel
--
Fax
--
Email
enquiry@leawell.com.cn
Country
China
ProdList
505
Advantage
56
Richchem International Trading Co., Ltd
Tel
--
Fax
--
Email
sinochemx@online.ln.cn
Country
China
ProdList
738
Advantage
69
Shanghai New Union Textra Import & Export Co., Ltd
Tel
--
Fax
--
Email
zhou@pharmchemical.com
Country
China
ProdList
2748
Advantage
60
More
Less

View Lastest Price from Moexipril manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Moexipril 103775-10-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-26
Career Henan Chemical Co
Product
Moexipril 103775-10-6
Price
US $1.00/KG
Min. Order
1KG
Purity
98%HPLC
Supply Ability
10 tons/month
Release date
2020-01-07

103775-10-6, MoexiprilRelated Search:

Diphenyl ether Ethoxyamine hydrochloride Ethoxyethyne Moxifloxacin Isopropyl alcohol Ethoxyquin PHENYL VALERATE Propyl butyrate Tamoxifen citrate Phenyl salicylate ALTRENOGEST Acipimox Propyl gallate DIETHOXYMETHANE Dimethoxymethane Ethoxymethylenemalononitrile Tamoxifen PHENYL RESIN

  • MOEXIPRIL
  • 2-[2-[(1-ethoxycarbonyl-3-phenyl-propyl)amino]propanoyl]-6,7-dimethoxy-3,4-dihydro-1h-isoquinoline-3-carboxylic acid
  • (3S)-2-[(2S)-2-[[(1S)-1-carbethoxy-3-phenyl-propyl]amino]propanoyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-3-carboxylic acid
  • (3S)-2-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenyl-butan-2-yl]amino]propanoyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-3-carboxylic acid
  • (3S)-2-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-3-carboxylic acid
  • (3S)-2-{N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl}-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
  • MoexiprilC27H34N207
  • Moexiv hydrochloride
  • (3S)-2-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]aMino}propanoyl]-6,7-diMethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
  • (3R)-2-[(2S)-2-[[(2R)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-1-oxopropyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-3-carboxylic acid
  • 3-Isoquinolinecarboxylic acid,2-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-, (3S)-
  • Moexipril USP/EP/BP
  • 103775-10-6
  • C27H34N2O7
  • Miscellaneous Biochemicals