2-(1-Adamantyl)-4-bromophenol

Product Name: 2-(1-Adamantyl)-4-bromophenol
CAS No.: 104224-68-2
Chemical Name: 2-(1-Adamantyl)-4-bromophenol
Synonyms: 2-(1-Adamantyl)-4-br;4-BROMO-2-ADAMANTYL PHENOL;2-ADAMANTANE-4-BROMOANISOLE;(2-ADAMANTYL)-4-BROMOPHENOL;2-(2-adamantyl)-4-bromophenol;2-(1-ADAMANTYL)-4-BROMOPHENOL;2-(Adamantan-1-yl)-4-bromophenol;2-(Adamantan-1-yl)-4-bromophenol 98%;2-(1-Adamantyl)-4-bromophenol (Adapalene);Phenol, 4-bromo-2-tricyclo[3.3.1.13,7]dec-1-yl-
CBNumber: CB9339345
Molecular Formula: C16H19BrO
Formula Weight: 307.23
MOL File: 104224-68-2.mol

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2-(1-Adamantyl)-4-bromophenol Property

Melting point:: 137-141
Boiling point:: 392.0±35.0 °C(Predicted)
Density: 1.442±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: 9.56±0.43(Predicted)
Appearance: Off-white to light yellow Solid
InChI: InChI=1S/C16H19BrO/c17-13-1-2-15(18)14(6-13)16-7-10-3-11(8-16)5-12(4-10)9-16/h1-2,6,10-12,18H,3-5,7-9H2
InChIKey: NYJXKHIVLGWPCF-UHFFFAOYSA-N
SMILES: C1(O)=CC=C(Br)C=C1C12CC3CC(CC(C3)C1)C2
CAS DataBase Reference: 104224-68-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Hazard Note: Irritant
HS Code: 2907290090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: A210050
Product name: 2-(Adamantan-1-yl)-4-bromophenol
Packaging: 250mg
Price: $1260
Updated: 2021/12/16

Matrix Scientific

Product number: 090786
Product name: 2-(1-Adamantyl)-4-bromophenol
Purity: 95+%
Packaging: 1g
Price: $76
Updated: 2021/12/16

Apolloscientific

Product number: OR3491
Product name: 2-(Adamantan-1-yl)-4-bromophenol
Purity: 98%
Packaging: 1g
Price: $82
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA70832
Product name: 2-(1-Adamantyl)-4-bromophenol
Packaging: 5G
Price: $90
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2201-9-01
Product name: 2-(Adamantan-1-yl)-4-bromophenol
Purity: 98%
Packaging: 1g
Price: $96
Updated: 2021/12/16

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2-(1-Adamantyl)-4-bromophenol Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

2-(Adamantan-1-yl)-4-bromophenol is an intermediate in the synthesis of Adapalene (A225000), a retinoid selective for retinoic acid receptor (RAR) subtypes β and γ; an antiacne agent.

Synthesis

106-41-2

768-95-6

104224-68-2

Preparation of 2-(1-adamantyl)-4-bromophenol (III): 4-bromophenol (10.0 g, 57.8 mmol) was dissolved in methanesulfonic acid (15 mL) with 1-adamantanol (8.78 g, 57.76 mmol), and the reaction was stirred for 3 hr at 70 °C. After completion of the reaction, the mixture was cooled to room temperature and diluted with deionized water (50 mL). The precipitated white solid was collected by filtration, washed several times with deionized water and subsequently dried to afford the target product 2-(1-adamantyl)-4-bromophenol (III). [Yield: 17 g, Yield: 97%]

References

[1] Bioorganic Chemistry, 2011, vol. 39, # 4, p. 151 - 158
[2] RSC Advances, 2016, vol. 6, # 73, p. 68560 - 68567
[3] Organic Process Research and Development, 2006, vol. 10, # 2, p. 285 - 288
[4] Beilstein Journal of Organic Chemistry, 2012, vol. 8, p. 227 - 233
[5] Patent: WO2007/125542, 2007, A2. Location in patent: Page/Page column 13-14

2-(1-Adamantyl)-4-bromophenol Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(1-Adamantyl)-4-bromophenol Suppliers

China 118 Europe 2 Germany 1 India 9 Ukraine 1 United Kingdom 9 United States 15 Global 155

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View Lastest Price from 2-(1-Adamantyl)-4-bromophenol manufacturers

Shenzhen Nexcon Pharmatechs Ltd.

Product: 2-(1-Adamantyl)-4-bromophenol 104224-68-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 2000
Release date: 2025-06-19

Shanghai Qyubiotech Co., Ltd.

Product: 2-(1-Adamantyl)-4-bromophenol 104224-68-2
Price: US $0.00-0.00/g
Min. Order: 10g
Purity: 98%+
Supply Ability: 100kgs per Month
Release date: 2022-10-17

Longyan Tianhua Biological Technology Co., Ltd

Product: 2-(1-Adamantyl)-4-bromophenol 104224-68-2
Price: US $100.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000kg
Release date: 2020-11-16

104224-68-2, 2-(1-Adamantyl)-4-bromophenolRelated Search:

3-Bromophenol 4-Bromophenol Bromophenol Blue 1-[2-(Benzyloxy)-5-bromophenyl]adamantane 2-Adamantyl-4-bromo-1-(2,2,2-trifluoroethoxy)benzene 1-(5-Bromo-2-methoxy-phenyl)adamantane 1-Bromo-3-n-hexylbenzene, 97+% 1-Phenyladamantane 3-tert-butylbromobenzene Adapalene 4-Bromoanisole Adamantane bromophenol 4-(1-ADAMANTYL)-2-BROMOPHENOL 2-(1-Adamantyl)-4-bromophenol

2-(1-Adamantyl)-4-bromophenol (Adapalene)

2-(1-Adamantyl)-4-br

4-BROMO-2-ADAMANTYL PHENOL

2-(2-adamantyl)-4-bromophenol

(2-ADAMANTYL)-4-BROMOPHENOL

2-(1-ADAMANTYL)-4-BROMOPHENOL

2-(Adamantan-1-yl)-4-bromophenol

2-ADAMANTANE-4-BROMOANISOLE

2-(Adamantan-1-yl)-4-bromophenol 98%

2-(1-Adamantyl)-4-bromophenol CAS NO: 104224-68-2

Phenol, 4-bromo-2-tricyclo[3.3.1.13,7]dec-1-yl-

2-(1-Adamantyl)-4-bromophenol ISO 9001：2015 REACH

104224-68-2

116437-98-8

C16H19BrO

Adamantane derivatives

Phenol&Thiophenol&Mercaptan

APIs Intermediate

blocks

Bromides