ChemicalBook > CAS DataBase List > 1-Acetylimidazole

1-Acetylimidazole

Product Name
1-Acetylimidazole
CAS No.
2466-76-4
Chemical Name
1-Acetylimidazole
Synonyms
NAI;1-(1H-imidazol-1-yl)ethan-1-one;Acetylimidazole;4-ACETYLIMIDAZOLE;1-Imidazol-1-ylethanone;1-Acetylimida;N-ACETYLIMIDAZOL;1-AcetliMidazole;1-acetyl-imidazol;N-ACETYLIMIDAZOLE
CBNumber
CB9339608
Molecular Formula
C5H6N2O
Formula Weight
110.11
MOL File
2466-76-4.mol
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1-Acetylimidazole Property

Melting point:
99-105 °C (lit.)
Boiling point:
206.4°C (rough estimate)
Density 
1.2111 (rough estimate)
refractive index 
1.4800 (estimate)
storage temp. 
2-8°C
solubility 
water: soluble50mg/mL, clear, colorless
pka
pKa 3.6(H2O,t = 25,I=0.2) (Uncertain)
form 
Adhering Crystals or Crystalline Powder
color 
White to beige or light tan
Water Solubility 
Hydrolyzes in water. Solubility in methanol (almost transparency).
Sensitive 
Moisture Sensitive
BRN 
108425
Stability:
Moisture Sensitive
CAS DataBase Reference
2466-76-4(CAS DataBase Reference)
NIST Chemistry Reference
1H-Imidazole, 1-acetyl-(2466-76-4)
EPA Substance Registry System
1H-Imidazole, 1-acetyl- (2466-76-4)
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Safety

Risk Statements 
36/37/38
Safety Statements 
24/25
WGK Germany 
3
RTECS 
NI3400000
F 
10-21
TSCA 
Yes
HS Code 
29332900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.51210
Product name
1-Acetylimidazole
Purity
Novabiochem?
Packaging
25G
Price
$27.2
Updated
2024/03/01
Sigma-Aldrich
Product number
157864
Product name
1-Acetylimidazole
Purity
98%
Packaging
25g
Price
$53.1
Updated
2024/03/01
Sigma-Aldrich
Product number
8.51210
Product name
1-Acetylimidazole
Purity
Novabiochem?
Packaging
100G
Price
$97.1
Updated
2024/03/01
Sigma-Aldrich
Product number
157864
Product name
1-Acetylimidazole
Purity
98%
Packaging
1kg
Price
$467.4
Updated
2024/03/01
TCI Chemical
Product number
A0694
Product name
N-Acetylimidazole
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$97
Updated
2024/03/01
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1-Acetylimidazole Chemical Properties,Usage,Production

Chemical Properties

white to beige or light tan adhering crystals or

Uses

Acetylating agent for capping unreacted amino groups in peptide synthesis.

Uses

It is a mild acylating agent and its reactivity can be enhanced by quaternization with, e.g. benzyl bromide. 1-Acetylimidazole was used as acetylation reagent for amino groups. It was also employed for acetylation of histones. It is relatively specific reagent for tyrosyl residue acetylatioa dn a reagent used in the synthesis of annulated imidazole derivatives.

Uses

Relatively specific reagent for tyrosyl residue acetylation. Reagent used in the synthesis of annulated imidazole derivatives.

Definition

ChEBI: N-acetylimidazole is a N-acylimidazole.

General Description

Rate of solvolysis of 1-acetylimidazole in acid solutions was evaluated. Reaction of 1-acetylimidazole with orthophosphate and adenosine-5′-phosphate has been reported.

Purification Methods

It is recrystallised from isopropenyl acetate and dried in a vacuum over P2O5. [Riordan & Valee Methods Enzymol 25 500 1972, Beilstein 23/4 V 218.]

1-Acetylimidazole Preparation Products And Raw materials

Raw materials

Isopropenyl acetate

Preparation Products

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1-Acetylimidazole Suppliers

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View Lastest Price from 1-Acetylimidazole manufacturers

HebeiShuoshengImportandExportco.,Ltd
Product
1-Acetylimidazole 2466-76-4
Price
US $6.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000KG/Month
Release date
2024-08-08
Hebei Longbang Technology Co., Ltd
Product
1-Acetylimidazole 2466-76-4
Price
US $6.00/kg
Min. Order
1kg
Purity
More than 99%
Supply Ability
2000KG/Month
Release date
2024-04-28
Hebei Jingbo New Material Technology Co., Ltd
Product
1-Acetylimidazole 2466-76-4
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000000
Release date
2023-12-21

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  • Acylation (GC Derivatizing Reagents)
  • GC Derivatizing Reagents
  • BioChemical
  • Specific Amino Acid Modification
  • Proteomics and Protein Expression
  • Protein Modification
  • Proteomics
  • Reagents for tyrosine modification
  • amino
  • ImidazolesProtein Modification
  • Reagents for tyrosine modification
  • Building Blocks
  • Heterocyclic Building Blocks
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  • Acylation (GC Derivatizing Reagents)
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  • Analytical Chemistry
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