ChemicalBook > CAS DataBase List > (R)-2-Methyl-pyrrolidine
(R)-2-Methyl-pyrrolidine
- Product Name
- (R)-2-Methyl-pyrrolidine
- CAS No.
- 41720-98-3
- Chemical Name
- (R)-2-Methyl-pyrrolidine
- Synonyms
- (2R)-2-Methylpyrrolidine;C-3166R;D-2-METHYLPYRROLIDINE;Methylpyrrolidine hcl;2-(R)-Methylpyrrolidine;METHYLPYRROLIDINE(S-2-);(R)-2-METHYL-PYRROLIDINE;(2R)-2-Methylpyrrolidine hcl;Pyrrolidine, 2-methyl-, (2R)-;(R)-(?)-2-Methylpyrrolidine
- CBNumber
- CB9343250
- Molecular Formula
- C5H11N
- Formula Weight
- 85.15
- MOL File
- 41720-98-3.mol
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(R)-2-Methyl-pyrrolidine Property
- Boiling point:
- 94 °C(Press: 728 Torr)
- Density
- 0.842
- refractive index
- 1.4353
- Flash point:
- 45 ºF
- storage temp.
- 2-8°C
- pka
- 10.93±0.10(Predicted)
- form
- oil
- color
- Colourless to pale yellow
- Water Solubility
- Insoluble in water.
- InChI
- InChI=1S/C5H11N/c1-5-3-2-4-6-5/h5-6H,2-4H2,1H3/t5-/m1/s1
- InChIKey
- RGHPCLZJAFCTIK-RXMQYKEDSA-N
- SMILES
- N1CCC[C@H]1C
- CAS DataBase Reference
- 41720-98-3(CAS DataBase Reference)
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Safety
- Hazard Codes
- C,F
- Risk Statements
- 11-22-34
- Safety Statements
- 26-36/37/39-45
- RIDADR
- UN 2924
- WGK Germany
- 3
- Hazard Note
- Corrosive/Highly Flammable
- HazardClass
- 3
- PackingGroup
- Ⅱ
- HS Code
- 29339900
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H302Harmful if swallowed
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 679097
- Product name
- (R)-(?)-2-Methylpyrrolidine
- Packaging
- 1g
- Price
- $153.02
- Updated
- 2025/07/31
TCI Chemical
- Product number
- M3655
- Product name
- (R)-2-Methylpyrrolidine
- Purity
- min. 98.0 %
- Packaging
- 200MG
- Price
- $43
- Updated
- 2025/07/31
TCI Chemical
- Product number
- M3655
- Product name
- (R)-2-Methylpyrrolidine
- Purity
- min. 98.0 %
- Packaging
- 1G
- Price
- $129
- Updated
- 2025/07/31
Activate Scientific
- Product number
- AS44074-A
- Product name
- (R)-2-Methylpyrrolidine
- Purity
- 95% ee
- Packaging
- 1g
- Price
- $147
- Updated
- 2021/12/16
Ark Pharm
- Product number
- P000625626
- Product name
- (R)-2-Methylpyrrolidine
- Purity
- 97%
- Packaging
- 250mg
- Price
- $29
- Updated
- 2021/12/16
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(R)-2-Methyl-pyrrolidine Chemical Properties,Usage,Production
Uses
It is used as a building block used in a multikilogram synthesis of a chiral naphthalenoid histamine receptor antagonist.
Definition
ChEBI: (R)-2-methylpyrrolidine is a 2-methylpyrrolidine that has (R)-configuration. It is a conjugate base of a (R)-2-methylpyrrolidinium.
Application
(R)-2-Methyl-pyrrolidine, an optically active amine that can be used as a key building block to synthesize:
4,5-fused pyridazinone derivatives are applicable as potent histamine H3 receptor antagonists.
Naphthalenoid histamine H3 receptor antagonist.
Pyrrolo[2,3-d]pyrimidine derivatives as potent inhibitors of leucine-rich repeat kinase 2.
Synthesis
872-32-2
765-38-8
The general procedure for the synthesis of 2-methylpyrrolidine from 2-methylpyrroline was as follows: the whole-cell biotransformation reaction was carried out in sodium phosphate buffer (100 mM, pH 7.0) at 30 °C and 1000 rpm. Freshly harvested resting cells of E. coli BL21(DE3) expressing IRED with a final OD600nm adjusted to 90 were used.The reaction mixture contained 2.5 or 5 mM of imine substrate and 50 mM of glucose.
References
Synthesis and structure-activity relationships of 4,5-fused pyridazinones as histamine H3 receptor antagonists. DOI:10.1016/j.bmcl.2011.08.045
Efficient and Practical Synthesis of (R)-2-Methylpyrrolidine DOI:10.1021/jo060319n
(R)-2-Methyl-pyrrolidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (R)-2-Methyl-pyrrolidine manufacturers
Henan Aochuang Chemical Co.,Ltd.
- Product
- (R)-2-Methyl-pyrrolidine 41720-98-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-17
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- (R)-2-Methylpyrrolidine 41720-98-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- (R)-2-Methylpyrrolidine 41720-98-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
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