Benzyloxyacetic acid
- Product Name
- Benzyloxyacetic acid
- CAS No.
- 30379-55-6
- Chemical Name
- Benzyloxyacetic acid
- Synonyms
- 2-(benzyloxy)acetic acid;oxy)acetic acid;RARECHEM AL BE 0628;BENZYLOXYACETIC ACID;benzyloxy acctic acid;BenzyloxyaceticAcid>Benzyloxyacetic acid 95%;PHENYLMETHOXY ACETIC ACID;Benzyloxyacetic acid, 95%,;2-(phenylmethoxy)acetic acid
- CBNumber
- CB9346105
- Molecular Formula
- C9H10O3
- Formula Weight
- 166.17
- MOL File
- 30379-55-6.mol
Benzyloxyacetic acid Property
- Melting point:
- 80-81 °C
- Boiling point:
- 137-139 °C/0.6 mmHg (lit.)
- Density
- 1.162 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.526(lit.)
- Flash point:
- >230 °F
- storage temp.
- Sealed in dry,Room Temperature
- form
- clear liquid
- pka
- 3.52±0.10(Predicted)
- color
- Colorless to Light orange to Yellow
- InChI
- InChI=1S/C9H10O3/c10-9(11)7-12-6-8-4-2-1-3-5-8/h1-5H,6-7H2,(H,10,11)
- InChIKey
- GRZHHTYDZVRPIC-UHFFFAOYSA-N
- SMILES
- C(O)(=O)COCC1=CC=CC=C1
- CAS DataBase Reference
- 30379-55-6(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 432040
- Product name
- Benzyloxyacetic acid
- Purity
- 95%
- Packaging
- 5g
- Price
- $98.3
- Updated
- 2025/07/31
- Product number
- B2876
- Product name
- Benzyloxyacetic Acid
- Purity
- >97.0%(GC)(T)
- Packaging
- 1g
- Price
- $21
- Updated
- 2025/07/31
- Product number
- B2876
- Product name
- Benzyloxyacetic Acid
- Purity
- >97.0%(GC)(T)
- Packaging
- 5g
- Price
- $54
- Updated
- 2025/07/31
- Product number
- B288568
- Product name
- Benzyloxyacetic Acid
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 037594
- Product name
- (Benzyloxy)acetic acid
- Purity
- 95%
- Packaging
- 5g
- Price
- $19
- Updated
- 2021/12/16
Benzyloxyacetic acid Chemical Properties,Usage,Production
Chemical Properties
Colorless liquid
Uses
It is a compound for proteomics research use. It may be used for following synthesis mixed benzyloxyacetic pivalic anhydride, chiral glycolates, 1,2:4,5-di-O-isopropylidene-β-D-fructopyranos-3-yl benzyloxyacetate, via esterification, tetra aqua(1,10-phenanthroline-[κ]2N,N?)magnesium(II) bis[(2,4-dichlorophenyl)acetate], as ligand in the preparation of diaquabis(benzyloxyacetato)copper(II) complex.
Uses
Benzyloxyacetic acid may be used for the following syntheses:
- mixed benzyloxyacetic pivalic anhydride
- chiral glycolates, 1,2:4,5-di-O-isopropylidene-β-D-fructopyranos-3-yl benzyloxyacetate, via esterification
- tetraaqua(1,10-phenanthroline-[κ]2N,N′)magnesium(II) bis[(2,4-dichlorophenyl)acetate]
- as ligand in the preparation of diaquabis(benzyloxyacetato)copper(II) complex
Definition
ChEBI: (benzyloxy)acetic acid is a monocarboxylic acid that is benzyl alcohol in which the hydroxy group is replaced by a carboxymethoxy group. It is a monocarboxylic acid, an ether and a member of benzenes. It is functionally related to a benzyl alcohol and a glycolic acid.
General Description
In vitro activities of phenoxy and benzyloxyacetic acid derivatives as antisickling agents has been investigated by the application of quantitative structure activity relationship (QSAR) of Hansch-type.
Synthesis
79-11-8
100-51-6
30379-55-6
1. 960 g of tetrahydrofuran and 41 g of toluene were added to the reaction flask. 2. 534.0 g of potassium hydroxide was added in four batches at 10-20 °C. 3. 3. After the potassium hydroxide was added, 1371.1 g of benzyl alcohol was added in three batches. 4. 300.1 g of chloroacetic acid was dissolved in 480.5 g of tetrahydrofuran to prepare a tetrahydrofuran solution of chloroacetic acid. 5. The tetrahydrofuran solution of chloroacetic acid was added dropwise to the above reaction system, and the reaction temperature was maintained at 70-80 °C. 6. 6. React until the chloroacetic acid is completely consumed. 7. Cool the reaction system and add 3.12 kg of purified water. 8. 8. Remove the tetrahydrofuran by pressurized distillation. 9. 9. The aqueous phase was extracted four times with toluene. 10. 10. Adjust the pH of the aqueous phase to 3 with hydrochloric acid at 10-20°C. 11. 11. the aqueous phase was extracted twice with methyl tert-butyl ether. 12. The organic phase was concentrated to give 421.3 g of benzyloxyacetic acid (compound 3) in 88.3% yield and 99.2% GC purity. 13. The product was analyzed by 1H NMR. 13. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 12.28 (br, 1H), 7.34-7.30 (m, 5H), 4.59 (s, 2H), 4.12 (s, 2H).
References
[1] Chemistry - A European Journal, 1999, vol. 5, # 1, p. 121 - 161
[2] Tetrahedron, 2002, vol. 58, # 38, p. 7663 - 7679
[3] European Journal of Organic Chemistry, 2017, vol. 2017, # 3, p. 695 - 703
[4] Patent: US2017/190684, 2017, A1. Location in patent: Paragraph 0065; 0066; 0081
[5] Journal of the American Chemical Society, 2003, vol. 125, # 13, p. 3793 - 3798
Benzyloxyacetic acid Preparation Products And Raw materials
Raw materials
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View Lastest Price from Benzyloxyacetic acid manufacturers
- Product
- Benzyloxyacetic acid 30379-55-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2024-07-25
- Product
- Benzyloxyacetic acid 30379-55-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-26
- Product
- Benzyloxyacetic acid 30379-55-6
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2018-07-26