ChemicalBook > CAS DataBase List > Mestinon

Mestinon

Product Name: Mestinon
CAS No.: 101-26-8
Chemical Name: Mestinon
Synonyms: PYRIDOSTIGMINE BROMIDE;PYBR;3-(DIMETHYLCARBAMOYLOXY)-1-METHYLPYRIDINIUM BROMIDE;kalymin;regonal;kalimin;ro1-5130;mestinon;3-Hydroxy-1-;mestinonbromide
CBNumber: CB9356274
Molecular Formula: C9H13BrN2O2
Formula Weight: 261.12
MOL File: 101-26-8.mol

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Mestinon Property

Melting point:: 154 °C
storage temp.: 2-8°C
solubility: Very soluble in water and in ethanol (96 per cent).
form: Solid
color: White to Almost white
Merck: 14,7977
BCS Class: 3
InChI: InChI=1S/C9H13N2O2.BrH/c1-10(2)9(12)13-8-5-4-6-11(3)7-8;/h4-7H,1-3H3;1H/q+1;/p-1
InChIKey: VNYBTNPBYXSMOO-UHFFFAOYSA-M
SMILES: C1(C=CC=[N+](C)C=1)OC(=O)N(C)C.[Br-]
CAS DataBase Reference: 101-26-8(CAS DataBase Reference)
EPA Substance Registry System: Pyridinium, 3-[[(dimethylamino)carbonyl]oxy]-1-methyl-, bromide (1:1) (101-26-8)

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Safety

Hazard Codes: T+
Risk Statements: 26/27/28-43
Safety Statements: 22-36/37/39-45
RIDADR: UN 2811 6.1/PG 2
WGK Germany: 3
RTECS: UU5270000
HazardClass: 6.1
PackingGroup: II
HS Code: 2933399090
Hazardous Substances Data: 101-26-8(Hazardous Substances Data)
Toxicity: man,TDLo,oral,9mg/kg (9mg/kg),PERIPHERAL NERVE AND SENSATION: FASCICULATIONS,Israel Journal of Medical Sciences. Vol. 27, Pg. 659, 1991.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P262Do not get in eyes, on skin, or on clothing.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P9797
Product name: Pyridostigmine bromide
Packaging: 1g
Price: $145
Updated: 2025/07/31

Sigma-Aldrich

Product number: PHR3120
Product name: Pyridostigmine Bromide
Purity: pharmaceutical secondary standard, certified reference material
Packaging: 500MG
Price: $185.25
Updated: 2025/07/31

Sigma-Aldrich

Product number: P4099900
Product name: Pyridostigmine bromide
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 30 mg
Price: $167
Updated: 2025/07/31

Sigma-Aldrich

Product number: BP1033
Product name: Pyridostigmine bromide
Purity: British Pharmacopoeia (BP) Reference Standard
Packaging: 50MG
Price: $231
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1586009
Product name: Pyridostigmine bromide
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $425
Updated: 2025/07/31

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Mestinon Chemical Properties,Usage,Production

Description

Pyridostigmine is an inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE; IC₅₀s = 0.35 and 1 μM, respectively, for the human enzymes). Pyridostigmine (10 μM) reduces decreases in AChE activity induced by the organophosphate pesticides diisopropyl fluorophosphate, chlorpyrifos-oxon, diazinon-oxon, paraoxon, and malaoxon in isolated bovine red blood cells. It also reduces soman-induced membrane depolarization and decreases in AChE activity in isolated human muscle bundles in a concentration-dependent manner. Pyridostigmine (3 mg/kg per day for four weeks) prevents tachycardia and increases in sympathetic tone in mice following myocardial infarction induced by left coronary artery ligation. Formulations containing pyridostigmine have been used in the treatment of myasthenia gravis and as neuromuscular protective agents against organophosphate poisoning.

Chemical Properties

White Solid

Uses

Cholinergic, used in the treatment of myasthenia gravis, and is a pre-exposure antidote to chemical warfare agents.

Definition

ChEBI: Pyridostigmine bromide is a pyridinium salt.

brand name

Mestinon (Valeant); Regonol (Sandoz).

General Description

Pyridostigmine bromide,3-hydroxy-1-methylpyridinium bromide dimethylcarbamateor pyridostigmine bromide (Mestinon), occurs as a white, hygroscopic,crystalline powder with an agreeable, characteristicodor. It is freely soluble in water, alcohol, and chloroform.
Pyridostigmine bromide is about one fifth as toxic asneostigmine. It appears to function in a manner similar tothat of neostigmine and is the most widely used anticholinesteraseagent for treating myasthenia gravis. Theliver enzymes and plasma cholinesterase metabolize thedrug. The principal metabolite is 3-hydroxy-N-methylpyridinium.Orally administered pyridostigmine has a half-lifeof 90 minutes and a duration of action of between 3 and6 hours.

Biochem/physiol Actions

Acetylcholinesterase inhibitor.

Clinical Use

Myasthenia gravis

Drug interactions

Potentially hazardous interactions with other drugs
Aminoglycosides, clindamycin and polymyxins antagonise effects of pyridostigmine.

Metabolism

Pyridostigmine undergoes hydrolysis by cholinesterases and is also metabolised in the liver. It appears that 75% of the plasma clearance of pyridostigmine depends on renal function. 3-Hydroxy-N-methylpyridinium has been identified as one of the 3 metabolites isolated from the urine. Pyridostigmine is excreted mainly in the urine as unchanged drug and metabolites.

References

[1] ALEXEY D. STRELNIK . Novel potent pyridoxine-based inhibitors of AChE and BChE, structural analogs of pyridostigmine, with improved in vivo safety profile[J]. Bioorganic & Medicinal Chemistry Letters, 2016, 26 16: Pages 4092-4094. DOI: 10.1016/j.bmcl.2016.06.070
[2] JOHN D. HENDERSON. Pyridostigmine bromide protection against acetylcholinesterase inhibition by pesticides[J]. Journal of Biochemical and Molecular Toxicology, 2011, 26 1: 31-34. DOI: 10.1002/jbt.20410
[3] RICARDO A MASELLI. Protection of human muscle acetylcholinesterase from soman by pyridostigmine bromide.[J]. Muscle & Nerve, 2011, 43 4: 591-595. DOI: 10.1002/mus.21922
[4] MARINA T DURAND. Pyridostigmine restores cardiac autonomic balance after small myocardial infarction in mice.[J]. PLoS ONE, 2014: e104476. DOI: 10.1371/journal.pone.0104476

Mestinon Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Mestinon manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Mestinon 101-26-8
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 98.5%-101%;EP
Supply Ability: 500 KG
Release date: 2021-06-03

Baoji Guokang Healthchem Co., Ltd.

Product: Mestinon 101-26-8
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2021-06-03

Baoji Guokang Healthchem co.,ltd

Product: Mestinon 101-26-8
Price: US $420.00/Kg/Bag
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000kg
Release date: 2021-06-02

101-26-8, MestinonRelated Search:

4-Hydroxybenzoic acid 3-Hydroxybenzoic acid 2'-Hydroxy-3-phenylpropiophenone Zinc picolinate PYRAZOPHOS Dimethyl phthalate Dimethyl isophthalate Sodium bromate Rocuronium bromide Vecuronium bromide 2-Picolinic acid Allyl bromide Chromium picolinate Dimidium bromide Rivastigmine 3-Dimethylaminopropylamine CARBONYL SULFIDE Methylparaben

(1-methylpyridin-1-ium-3-yl) N,N-dimethylcarbamate

mestinonbromide

mestinonebromide

pyridinium,3-hydroxy-1-methyl-,bromide,dimethylcarbamate(ester)

pyridinium,3-hydroxyl-1-methyl-,bromide,dimethylcarbamate

regonal

ro1-5130

PYRIDOSTIGMINE BROMIDE

PYBR

1-methyl-3-hydroxypyridiniumbromidedimethylcarbamate

Pyridostigminebromide(NTPB)

PYRIDOSTIGMINEBROMIDE,USP

Pyridostigminbromid

(1-Methylpyridin-1-ium-3-yl) N,N-dimethylcarbamate bromide

2-Propan-2-ylsulfanylethanol

3-Hydroxy-1-

N,N-dimethylcarbamic acid (1-methylpyridin-1-ium-3-yl) ester bromide

PyridostigminebromideBP/USP

PYRIDOSTIGMINE BROMIDE CHOLINESTERASE IN HIBI

Pyridostigmine bromide,3-(Dimethylaminocarbonyloxy)-1-methylpyridinium bromide

Pyridostigmine Bromide (200 mg)

Pyridostigmine Bromide (200 mg)I0C3240.999mg/mg(dr)

3-diMethylaMino pyridine acyloxy

3-(((dimethylamino)carbonyl)oxy)-1-methyl-pyridiniubromide

3-(dimethylcarbamyloxy)-1-methylpyridiniumbromide

3-hydroxy-1-methylpyridiniumbromidedimethylcarbamate

3-hydroxy-1-methylpyridiniumbromidedimethylcarbamate(ester)

dimethylcarbamicacidesterof3-hydroxy-1-methylpyridiniumbromide

kalimin

kalymin

3-(DIMETHYLCARBAMOYLOXY)-1-METHYLPYRIDINIUM BROMIDE

3-(DIMETHYLAMINOCARBONYLOXY)-1-METHYLPYRIDINIUM BROMIDE

3-DIMETHYLAMINOCARBONYLOXY-N-METHYL-PYRIDINIUM BROMIDE

mestinon

3-[(diMethylcarbaMoyl)oxy]-1-Methylpyridin-1-iuM

3-[[(DiMethylaMino)carbonyl]oxy]-1-MethylpyridiniuM BroMid

3-((diMethylcarbaMoyl)oxy)-1-Methylpyridin-1-iuM broMide

PyridostigMine BroMide (Mestinon)

BroMine pyridostigMine

Pyridinium, 3-[[(dimethylamino)carbonyl]oxy]-1-methyl-, bromide (1:1)

Pyridostigmine bromide CRS

[2H6]-Pyridostigmine Bromide

Mestinon USP/EP/BP

Pyridostigmine bromide (P4099900)

Pyridostigmine D6 BromideQ: What is Pyridostigmine D6 Bromide Q: What is the CAS Number of Pyridostigmine D6 Bromide Q: What is the storage condition of Pyridostigmine D6 Bromide Q: What are the applications of Pyridostigmine D6 Bromide

Pyridostigmine Bromide (1586009)

2-dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1

2-dimethoxyethyl)-5-methoxy-6-methoxycarbonyl-4-oxopyridine-3-carboxylic acid

4-dihydropyridine-3-carboxylic acid

Pyridamine bromide

Pyridostigmine Bromide, ≥ 98.0%

Pyridostigmine bromide RS

1-methyl-D3-Pyridostigmine Bromide

D6-Pyridostigmine bromide

101-26-8

C9H13BrN2O2

Pyridinium Compounds

Pharmaceutical raw material