SR-95531

Product Name: SR-95531
CAS No.: 104104-50-9
Chemical Name: SR-95531
Synonyms: GABAZINE;SR-95531;GABAZINE BROMIDE;SR 95531 hydrobromid;Gabazine Hydrobromide;SR 95531 HYDROBROMIDE;SR 95531 hydrobromide NEW;Gabazine bromide (SR95531);4-[6-imino-3-(4-methoxyphenyl)pyridazin-1-yl]butanoic acid;2-(3-CARBOXYPROPYL)-3-AMINO-6-(4-METHOXYPHENYL)PYRIDAZINIUM
CBNumber: CB9356638
Molecular Formula: C15H18BrN3O3
Formula Weight: 368.23
MOL File: 104104-50-9.mol

More

Less

SR-95531 Property

Melting point:: 200 °C(Solv: ethanol (64-17-5))
storage temp.: Store at RT
solubility: DMSO: 30 mg/mL
form: solid
color: white

More

Less

Safety

WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S106
Product name: SR-95531
Purity: ≥98% (HPLC), powder
Packaging: 50mg
Price: $644
Updated: 2024/03/01

Sigma-Aldrich

Product number: 5.05986
Product name: SR95531 (Gabazine) - CAS 104104-50-9 - Calbiochem
Packaging: 10mg
Price: $155
Updated: 2024/03/01

Cayman Chemical

Product number: 14585
Product name: SR 95531 (hydrobromide)
Purity: ≥98%
Packaging: 5mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 14585
Product name: SR 95531 (hydrobromide)
Purity: ≥98%
Packaging: 10mg
Price: $116
Updated: 2024/03/01

Sigma-Aldrich

Product number: S106
Product name: SR-95531
Purity: ≥98% (HPLC), powder
Packaging: 10mg
Price: $191
Updated: 2024/03/01

More

Less

SR-95531 Chemical Properties,Usage,Production

Description

SR 95531 is a derivative of γ-aminobutyric acid (GABA) that acts as an antagonist of GABA_A receptors (K_i = 74-150 nM). When administered intravenously, it elicits seizures in mice. SR 95531 differs in action from bicuculline in that it antagonizes GABA-induced chloride currents but not those induced by pentobarbitone. It is effective against GABA_A receptor isoforms from mice, rats, and humans.

Uses

Gabazine Hydrobromide is a specific GABA receptor antagonist. Does not affect GABA-transaminase or glutamate-decarboxylase activitites.

Biological Activity

Selective, competitive GABA A receptor antagonist. Displaces [ 3 H]-GABA from rat brain membranes with a K i of 150 nM. Unlike bicuculline, selectively antagonizes GABA-induced Cl - currents with little action on pentobarbitone-induced currents. Also acts as a low affinity glycine receptor antagonist.

Biochem/physiol Actions

SR-95531 is a specific GABAA receptor antagonist that does not affect GABA-transaminase or glutamate-decarboxylase activities.

storage

Room temperature

SR-95531 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

SR-95531 Suppliers

China 70 Europe 1 Germany 2 India 3 Switzerland 1 United Kingdom 4 United States 11 Global 92

Carbosynth

Tel: --
Fax: --
Email: sales@carbosynth.com
Country: United Kingdom
ProdList: 6005
Advantage: 58

Tocris Bioscience

Tel: --
Fax: --
Email: customerservice@tocris.co.uk
Country: United Kingdom
ProdList: 5726
Advantage: 77

MOLEKULA Ltd.

Tel: --
Fax: --
Email: kevinbanks@molekula.com
Country: United Kingdom
ProdList: 6140
Advantage: 66

Fluorochem Ltd

Tel: --
Fax: --
Email: vernam@fluorochem.co.uk
Country: United Kingdom
ProdList: 6375
Advantage: 65

104104-50-9, SR-95531Related Search:

SR 3677 dihydrochloride N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide SR 35021 SR-95531,SR 95531 HYDROBROMIDE,SR-95531 SPECIFIC GABA-A ANTAG,SR-95531,2-(3-Carboxypropyl)-3-amino-6-(4-methoxyphenyl)pyridazinium SR-95531 SR95531, [BUTYRYL-2,3-3H]-

Gabazine, 2-(3-Carboxypropyl)-3-amino-6-(4 methoxyphenyl)pyridazinium bromide

1(6H)-Pyridazinebutanoic acid, 6-imino-3-(4-methoxyphenyl)-, monohydrobromide

6-Amino-5-methyl-3-(4-methoxyphenyl)-1-pyridaziniumbutyric acid br

6-Imino-3-(4-methoxyphenyl)-1(6H)-pyridazinebutanoic acid monohydrobromide

Gabazine Hydrobromide

4-(6-Imino-3-(4-methoxyphenyl)pyridazin-1(6H)-yl)butanoic acid hydrobromide

GABAZINE

GABAZINE BROMIDE

2-(3-CARBOXYPROPYL)-3-AMINO-6-(4-METHOXYPHENYL)PYRIDAZINIUM

2-(3-CARBOXYPROPYL)-3-AMINO-6-(4 METHOXYPHENYL)PYRIDAZINIUM BROMIDE

6-IMINO-3-(4-METHOXYPHENYL)-1(6H)-PYRIDAZINEBUTANOIC ACID HYDROBROMIDE

SR 95531 HYDROBROMIDE

SR-95531

SR 95531 hydrobromide NEW

SR 95531 hydrobromid

4-[6-imino-3-(4-methoxyphenyl)pyridazin-1-yl]butanoic acid

Gabazine bromide (SR95531)

Inhibitor,Gamma-aminobutyric acid Receptor,Gabazine,γ-Aminobutyric acid Receptor,inhibit,SR 95531,GABA Receptor,SR-95531

104104-50-9

104105-50-9

C15H17N3O3HBr

C15H18BrN3O3

C15H18N3O3Br

Cell Biology

Cell Signaling and Neuroscience

BioChemical

Ion Channels

Ligand-Gated Ion Channels

GABA and Glycine Receptor Modulators

GABA/Glycine receptor