SR-95531

Product Name: SR-95531
CAS No.: 104104-50-9
Chemical Name: SR-95531
Synonyms: GABAZINE;SR-95531;SR-95531【S106】;GABAZINE BROMIDE;SR 95531 hydrobromid;Gabazine Hydrobromide;SR 95531 HYDROBROMIDE;Gabazine, 10 mM in DMSO;SR 95531 hydrobromide NEW;Gabazine bromide (SR95531)
CBNumber: CB9356638
Molecular Formula: C15H18BrN3O3
Formula Weight: 368.23
MOL File: 104104-50-9.mol

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SR-95531 Property

Melting point:: 200 °C(Solv: ethanol (64-17-5))
storage temp.: Store at RT
solubility: DMSO: 30 mg/mL
form: solid
color: white
Water Solubility: water: 25mM

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S106
Product name: SR-95531
Purity: ≥98% (HPLC), powder
Packaging: 50mg
Price: $662
Updated: 2025/07/31

Sigma-Aldrich

Product number: 5.05986
Product name: SR95531 (Gabazine) - CAS 104104-50-9 - Calbiochem
Packaging: 10mg
Price: $160
Updated: 2025/07/31

Cayman Chemical

Product number: 14585
Product name: SR 95531 (hydrobromide)
Purity: ≥98%
Packaging: 5mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 14585
Product name: SR 95531 (hydrobromide)
Purity: ≥98%
Packaging: 10mg
Price: $116
Updated: 2024/03/01

Sigma-Aldrich

Product number: S106
Product name: SR-95531
Purity: ≥98% (HPLC), powder
Packaging: 10mg
Price: $196
Updated: 2025/07/31

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SR-95531 Chemical Properties,Usage,Production

Description

SR 95531 is a derivative of γ-aminobutyric acid (GABA) that acts as an antagonist of GABA_A receptors (K_i = 74-150 nM). When administered intravenously, it elicits seizures in mice. SR 95531 differs in action from bicuculline in that it antagonizes GABA-induced chloride currents but not those induced by pentobarbitone. It is effective against GABA_A receptor isoforms from mice, rats, and humans.

Uses

Gabazine Hydrobromide is a specific GABA receptor antagonist. Does not affect GABA-transaminase or glutamate-decarboxylase activitites.

Biological Activity

Selective, competitive GABA A receptor antagonist. Displaces [ 3 H]-GABA from rat brain membranes with a K i of 150 nM. Unlike bicuculline, selectively antagonizes GABA-induced Cl - currents with little action on pentobarbitone-induced currents. Also acts as a low affinity glycine receptor antagonist.

Biochem/physiol Actions

SR-95531 is a specific GABAA receptor antagonist that does not affect GABA-transaminase or glutamate-decarboxylase activities.

storage

Room temperature

References

[1] MICHEL HEAULME . Biochemical characterization of the interaction of three pyridazinyl-GABA derivatives with the GABAA receptor site[J]. Brain Research, 1986, 384 2: Pages 224-231. DOI: 10.1016/0006-8993(86)91158-3
[2] ANITA MELIKIAN. Condensation of muscimol or thiomuscimol with aminopyridazines yields GABA-A antagonists[J]. Journal of Medicinal Chemistry, 1992, 35 22: 4092-4097. DOI: 10.1021/jm00100a015
[3] DORTE KREHAN. Potent 4-Arylalkyl-Substituted 3-Isothiazolol GABAA Competitive/Noncompetitive Antagonists: Synthesis and Pharmacology[J]. Journal of Medicinal Chemistry, 2006, 49 4: 1388-1396. DOI: 10.1021/jm050987l
[4] ICHIRO UCHIDA Jay Y Ismar N Cestari. The differential antagonism by bicuculline and SR95531 of pentobarbitone-induced currents in cultured hippocampal neurons[J]. European journal of pharmacology, 1996, 307 1: Pages 89-96. DOI: 10.1016/0014-2999(96)00156-2
[5] SURESH K MENDU. Different subtypes of GABA-A receptors are expressed in human, mouse and rat T lymphocytes.[J]. PLoS ONE, 2012: e42959. DOI: 10.1371/journal.pone.0042959

SR-95531 Preparation Products And Raw materials

Raw materials

Preparation Products

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SR-95531 Suppliers

China 97 Europe 1 Germany 2 India 3 Switzerland 1 United Kingdom 4 United States 12 Global 120

Carbosynth

Tel: --
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Email: sales@carbosynth.com
Country: United Kingdom
ProdList: 6005
Advantage: 58

Tocris Bioscience

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Email: customerservice@tocris.co.uk
Country: United Kingdom
ProdList: 5726
Advantage: 77

MOLEKULA Ltd.

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Email: kevinbanks@molekula.com
Country: United Kingdom
ProdList: 6140
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Fluorochem Ltd

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Email: vernam@fluorochem.co.uk
Country: United Kingdom
ProdList: 6375
Advantage: 65

104104-50-9, SR-95531Related Search:

SR 3677 dihydrochloride N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide SR 35021 SR-95531,SR 95531 HYDROBROMIDE,SR-95531 SPECIFIC GABA-A ANTAG,SR-95531,2-(3-Carboxypropyl)-3-amino-6-(4-methoxyphenyl)pyridazinium SR-95531 SR95531, [BUTYRYL-2,3-3H]-

Gabazine, 2-(3-Carboxypropyl)-3-amino-6-(4 methoxyphenyl)pyridazinium bromide

1(6H)-Pyridazinebutanoic acid, 6-imino-3-(4-methoxyphenyl)-, monohydrobromide

6-Amino-5-methyl-3-(4-methoxyphenyl)-1-pyridaziniumbutyric acid br

6-Imino-3-(4-methoxyphenyl)-1(6H)-pyridazinebutanoic acid monohydrobromide

Gabazine Hydrobromide

4-(6-Imino-3-(4-methoxyphenyl)pyridazin-1(6H)-yl)butanoic acid hydrobromide

GABAZINE

GABAZINE BROMIDE

2-(3-CARBOXYPROPYL)-3-AMINO-6-(4-METHOXYPHENYL)PYRIDAZINIUM

2-(3-CARBOXYPROPYL)-3-AMINO-6-(4 METHOXYPHENYL)PYRIDAZINIUM BROMIDE

6-IMINO-3-(4-METHOXYPHENYL)-1(6H)-PYRIDAZINEBUTANOIC ACID HYDROBROMIDE

SR 95531 HYDROBROMIDE

SR-95531

SR 95531 hydrobromide NEW

SR 95531 hydrobromid

4-[6-imino-3-(4-methoxyphenyl)pyridazin-1-yl]butanoic acid

Gabazine bromide (SR95531)

Inhibitor,Gamma-aminobutyric acid Receptor,Gabazine,γ-Aminobutyric acid Receptor,inhibit,SR 95531,GABA Receptor,SR-95531

SR95531 (Gabazine) (mM/ml), GABAA antagonist

SR95531 (Gabazine), GABAA antagonist

Gabazine, 10 mM in DMSO

SR-95531【S106】

104104-50-9

104105-50-9

C15H17N3O3HBr

C15H18BrN3O3

C15H18N3O3Br

Cell Biology

Cell Signaling and Neuroscience

BioChemical

Ion Channels

Ligand-Gated Ion Channels

GABA and Glycine Receptor Modulators

GABA/Glycine receptor