ChemicalBook > CAS DataBase List > 5,7-DIETHYL-3,4-DIHYDRO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,6-NAPHTHYRIDIN-2(1H)-ONE HYDROCHLORIDE

5,7-DIETHYL-3,4-DIHYDRO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,6-NAPHTHYRIDIN-2(1H)-ONE HYDROCHLORIDE

Product Name: 5,7-DIETHYL-3,4-DIHYDRO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,6-NAPHTHYRIDIN-2(1H)-ONE HYDROCHLORIDE
CAS No.: 146709-78-6
Chemical Name: 5,7-DIETHYL-3,4-DIHYDRO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,6-NAPHTHYRIDIN-2(1H)-ONE HYDROCHLORIDE
Synonyms: ZD7155HCl;ZD 7155 HYDROCHLORIDE;ZD7155 hydrochloride >=97% (HPLC);ZD 7155 hydrochloride, 10 mM in DMSO;5,7-Diethyl-3,4-dihydro-1-[[2(1H-tetrazol-5-yl)[1,1biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-onehydrochloride;5,7-DIETHYL-3,4-DIHYDRO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,6-NAPHTHYRIDIN-2(1H)-ONE HYDROCHLORIDE;1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-5,7-diethyl-3,4-dihydro-1,6-naphthyridin-2(1H)-one hydrochloride;1-((2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-5,7-diethyl-3,4-dihydro-1,6-naphthyridin-2(1H)-one hydrochloride
CBNumber: CB9360710
Molecular Formula: C26H27ClN6O
Formula Weight: 474.99
MOL File: 146709-78-6.mol

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5,7-DIETHYL-3,4-DIHYDRO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,6-NAPHTHYRIDIN-2(1H)-ONE HYDROCHLORIDE Property

storage temp.: Inert atmosphere,2-8°C
solubility: DMSO: 10 mM
form: Powder
color: White to yellow
Water Solubility: Soluble to 10 mM in water with gentle warming

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2114
Product name: ZD7155 hydrochloride
Purity: ≥97% (HPLC)
Packaging: 5 mg
Price: $87.21
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2114
Product name: ZD7155 hydrochloride
Purity: ≥97% (HPLC)
Packaging: 25 mg
Price: $295
Updated: 2025/07/31

Tocris

Product number: 1211
Product name: ZD7155hydrochloride
Purity: ≥98%(HPLC)
Packaging: 10
Price: $187
Updated: 2021/12/16

Tocris

Product number: 1211
Product name: ZD7155hydrochloride
Purity: ≥98%(HPLC)
Packaging: 50
Price: $787
Updated: 2021/12/16

TRC

Product number: Z157508
Product name: ZD7155Hydrochloride
Packaging: 10mg
Price: $180
Updated: 2021/12/16

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5,7-DIETHYL-3,4-DIHYDRO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,6-NAPHTHYRIDIN-2(1H)-ONE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

ZD 7155 Hydrochloride, is a potent and selective competitive antagonist for the angiotensin II type 1 (AT1) receptor. it is shown to be more active than the prototype AT1 antagonist, losartan, and it’s orally active.

Biological Activity

A potent and selective competitive antagonist for the angiotensin II type 1 (AT 1 ) receptor. Displaces [ 125 I]-angiotensin II binding with an IC 50 value of 3.8 nM in guinea pig adrenal gland membranes. Orally active, and is more potent and longer-acting than the prototype AT 1 antagonist, losartan.

in vivo

In conscious SD rats, ZD 7155 and losartan behave as competitive antagonists and the pressor response curve to angiotensin II is shifted to the right. Experiments in conscious SD rats also show that ZD 7155 is approximately ten times as potent as losartan in suppressing the angiotensin II-induced pressor response (240 ng/kg; 10 min infusion). In addition, experiments with conscious rats demonstrate that ZD 7155 could suppress the angiotensin II-induced pressor response for approximately 24 h when ZD 7155 is administered intravenously in a 1.082 μmol/kg bolus dose and angiotensin II is given at 240 ng/kg (in a 10-min infusion). Experiments in conscious SHRs using ZD 7155 (1.082 mumol/kg) and losartan (6.495 mumol/kg) as intravenous boluses indicate that both ZD 7155 and the reference compound losartan exhibit a significant antihypertensive effect^[1].

IC 50

AT1 Receptor

storage

Desiccate at +4°C

5,7-DIETHYL-3,4-DIHYDRO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,6-NAPHTHYRIDIN-2(1H)-ONE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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146709-78-6, 5,7-DIETHYL-3,4-DIHYDRO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,6-NAPHTHYRIDIN-2(1H)-ONE HYDROCHLORIDERelated Search:

ZD 7155 ICI D7114 1-METHYL-1,2,3,4-TETRAHYDRO-[1,6]NAPHTHYRIDINE 4-PYRIDINAMINE, 5-ETHYL-2-METHYL- 2,6-DIMETHYL-PYRIDIN-4-YLAMINE 3,4-DIHYDRO-1,6-NAPHTHYRIDIN-2(1H)-ONE C-BIPHENYL-4-YL-METHYLAMINE HYDROCHLORIDE 1,2,3,4-TETRAHYDRO-1,6-NAPHTHYRIDINE Acetamide,N-(2-methyl-4-pyridinyl)- 5,7-DIETHYL-3,4-DIHYDRO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,6-NAPHTHYRIDIN-2(1H)-ONE HYDROCHLORIDE

ZD 7155 HYDROCHLORIDE

5,7-DIETHYL-3,4-DIHYDRO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,6-NAPHTHYRIDIN-2(1H)-ONE HYDROCHLORIDE

5,7-Diethyl-3,4-dihydro-1-[[2(1H-tetrazol-5-yl)[1,1biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-onehydrochloride

ZD7155HCl

ZD7155 hydrochloride >=97% (HPLC)

1-((2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-5,7-diethyl-3,4-dihydro-1,6-naphthyridin-2(1H)-one hydrochloride

ZD 7155 hydrochloride, 10 mM in DMSO

1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-5,7-diethyl-3,4-dihydro-1,6-naphthyridin-2(1H)-one hydrochloride

146709-78-6

C26H27ClN6O

C26H26N6OHCl