ChemicalBook > CAS DataBase List > Scopolamine hydrobromide

Scopolamine hydrobromide

Product Name
Scopolamine hydrobromide
CAS No.
114-49-8
Chemical Name
Scopolamine hydrobromide
Synonyms
HYOSCINE;HYOSCINE HYDROBROMIDE;triptone;ScopolaMine HBr Trihydrate;hysco;Hyosol;kwells;scopos;sereen;scopamin
CBNumber
CB9363236
Molecular Formula
C17H21NO4.BrH
Formula Weight
384.26
MOL File
114-49-8.mol
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Scopolamine hydrobromide Property

Melting point:
195-199 °C (dry matter)(lit.)
alpha 
D25 -24 to -26° (c = 5, calculated on anhydrous basis)
storage temp. 
Store at RT
solubility 
H2O: 50 mg/mL
form 
powder
color 
white to off-white
InChI
InChI=1/C17H21NO4.BrH/c1-18-13-7-11(8-14(18)16-15(13)22-16)21-17(20)12(9-19)10-5-3-2-4-6-10;/h2-6,11-16,19H,7-9H2,1H3;1H/t11-,12-,13-,14+,15-,16+;/s3
InChIKey
WTGQALLALWYDJH-MLRWSLNSNA-N
SMILES
[C@]12([H])O[C@@]1([H])[C@@]1([H])N(C)[C@]2([H])C[C@@H](OC(=O)[C@H](CO)C2C=CC=CC=2)C1.Br |&1:0,3,5,9,12,16,r|
CAS DataBase Reference
114-49-8(CAS DataBase Reference)
EPA Substance Registry System
Scopolamine hydrobromide (114-49-8)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36
RIDADR 
UN 1544 6.1/PG 1
WGK Germany 
3
RTECS 
YM4550000
F 
3-8
HS Code 
2939800000
Toxicity
LD50 in rats (mg/kg): 3800 s.c. (Stockhaus, Wick)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
5.05818
Product name
Scopolamine Hydrobromide - CAS 114-49-8 - Calbiochem
Packaging
1G
Price
$126
Updated
2024/03/01
Cayman Chemical
Product number
14108
Product name
Scopolamine (hydrobromide)
Purity
≥95%
Packaging
1mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
14108
Product name
Scopolamine (hydrobromide)
Purity
≥95%
Packaging
5mg
Price
$355
Updated
2024/03/01
Tocris
Product number
1414
Product name
Scopolamine Hydrobromide
Purity
≥99%(HPLC)
Packaging
1G
Price
$87
Updated
2021/12/16
Matrix Scientific
Product number
102724
Product name
(1S,2R)-9-Methyl-3-oxa-9- azatricyclo[3.3.1.0{2,4}]nonan-7-yl- (2S)-3-hydroxy-2-phenylpropanoate trihydrate hydrobromide
Purity
>95%
Packaging
1g
Price
$102
Updated
2021/12/16
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Scopolamine hydrobromide Chemical Properties,Usage,Production

Description

Scopolamine is a tropane alkaloid that can be found in many plants of the Solanaceae (nightshade) family. It is a muscarinic receptor antagonist that can be used to induce memory impairment in animals. Scopolamine prevents motion sickness, nausea, and vomiting in animals.

Chemical Properties

Off-White Solid

Uses

An acetylcholine antagonist. Used in treatment of motion sickness; antiemetic; antispasmodic; mydriatic; preanesthetic medicant

Definition

ChEBI: A hydrobromide that is obtained by reaction of scopolamine with hydrogen bromide.

brand name

Isopto Hyoscine (Alcon); Transderm-Scop (Ciba-Geigy).

General Description

Scopolamine hydrobromide(hyoscine hydrobromide) occurs as white orcolorless crystals or as a white, granular powder. It is odorlessand tends to effloresce in dry air. It is freely soluble inwater (1:1.5), soluble in alcohol (1:20), only slightly solublein chloroform, and insoluble in ether.
Scopolamine is a competitive blocking agent of theparasympathetic nervous system as is atropine, but it differsmarkedly from atropine in its action on the higher nervecenters. Both drugs readily cross the blood-brain barrierand, even at therapeutic doses, cause confusion, particularlyin the elderly.

General Description

Colorless crystals or white powder or solid. Has no odor. pH (of 5% solution): 4-5.5. Slightly efflorescent in dry air. Bitter, acrid taste.

Air & Water Reactions

Sensitive to air, light and moisture. Water soluble.

Reactivity Profile

Scopolamine hydrobromide is incompatible with acids, bases and oxidizing agents. .

Fire Hazard

Flash point data for Scopolamine hydrobromide are not available; however, Scopolamine hydrobromide is probably combustible.

Biological Activity

Non-selective muscarinic antagonist. Widely used clinically to treat motion sickness.

Clinical Use

A sufficiently large dose of scopolamine will cause an individualto sink into a restful, dreamless sleep for about8 hours, followed by a period of approximately the samelength in which the patient is in a semiconscious state.During this time, the patient does not remember events thattake place. When scopolamine is administered with morphine,this temporary amnesia is termed twilight sleep.

Metabolism

Hyoscine hydrobromide is almost entirely metabolised, probably in the liver; only a small proportion of an oral dose is excreted unchanged in the urine. In one study in man, 3.4% of a single dose, administered by subcutaneous injection was excreted unchanged in urine within 72 hours.

storage

Store at RT

Purification Methods

The hydrobromide is recrystallised from Me2CO, H2O or EtOH/Et2O and dried. It is soluble in H2O (60%) and EtOH (5%) but insoluble in Et2O and slightly in CHCl3. The hydrochloride has m 300o (from Me2CO). The free base is a viscous liquid which forms a crystalline hydrate with m 59o and [] D 20 -28o (c 2.7, H2O). It hydrolyses in dilute acid or base. [Meinwald J Chem Soc 712 1953, Fodor Tetrahedron 1 86 1957, Beilstein 6 III 4185.]

Scopolamine hydrobromide Preparation Products And Raw materials

Raw materials

Nisin COREOPSISYELLOWEXTRACT

Preparation Products

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View Lastest Price from Scopolamine hydrobromide manufacturers

Changsha Staherb Natural Ingredients Co., Ltd.
Product
Scopolamine hydrobromide; Flos?daturae extract 114-49-8
Price
US $0.00/KG
Min. Order
1KG
Purity
99% HPLC
Supply Ability
1000KG
Release date
2022-09-21
ARCTIC EXPORTS INC
Product
Scopolamine 114-49-8
Price
US $0.00/kg
Min. Order
10kg
Purity
99% purity
Supply Ability
1000 kg
Release date
2023-12-18
Wuhan Han Sheng New Material Technology Co.，Ltd
Product
Scopolamine hydrobromide 114-49-8
Price
US $69.00-3669.00/g
Min. Order
10g
Purity
99%
Supply Ability
50tons
Release date
2023-05-06

114-49-8, Scopolamine hydrobromideRelated Search:

SCOPOLAMINE N-OXIDE HYDROBROMIDE Scopolamine Hydrobromide Trihydrate Scopolamine Pyridine hydrobromide Scopolamine butylbromide (-)-SCOPOLAMINE HYOSCINE HYDROCHLORIDE Scopine DL-(SCOPOLAMINE HYDROBROMIDE) Cimetropium bromide DEXTROMETHORPHAN HYDROBROMIDE HYOSCINE N BUTYL BROMIDE BP Methscopolamine bromide Tropic acid Scopoletin Hydrogen bromide DL-TROPIC ACID SCOPOLAMINE-D3 HBR 3H2O (N-METHYL-D3) Hyoscine Hydrobromide

  • Benzeneacetic acid, a-(hydroxyMethyl)-, (1a,2b,4b,5a,7b)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-ylester, hydrobroMide (1:1), (aS)-
  • ScopolaMine HBr Trihydrate
  • ScopolaMine-d3 HBr 3H2O
  • Hyosol
  • Tranaxine
  • Benzeneacetic acid, α-(hydroxymethyl)-, (1α,2β,4β,5α,7β)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl ester, hydrobromide (1:1), (αS)-
  • Hyoscine HydrobroMide Trihydrate, (1α,2β,4β,5α,7β)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl Ester HydrobroMide Trihydrate
  • SCOPOLAMINE HBR
  • (-)-SCOPOLAMINE HYDROBROMIDE
  • SCOPOLAMINE HYDROBROMIDE
  • SCOPOLOAMINE HYDROBROMIDE
  • SCOPINE TROPATE HYDROBROMIDE
  • (α,S)-α-(Hydroxymethyl)benzeneaceticacid(1α,2β,4β,5α,7β)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-ylesterhydrobromide
  • ()-Scopolamine hydrobromide trihydrate,Hyoscine hydrobromide, Scopine tropate
  • (-)-scopolaminebromide
  • ),hydrobromide
  • scopolamine hydrobromide (anhydrous)
  • Benzeneacetic acid, a-(hydroxymethyl)-, (1a,2b,4b,5a,7b)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl ester, hydrobromide, (aS)-
  • (alpha,S)-alpha-(Hydroxymethyl)benzeneacetic acid (1alpha,2beta,4beta,5alpha,7beta)-9-methyl-3-oxa-9-azatricyclo[3.3.1.0(2.4)]non-7-yl ester hydrobromide
  • (2S,3S,4S,5S)-2,5-bis(hydroxymethyl)pyrrolidine-3,4-diol
  • Scopolamine hydrobromide, 98%, from Datura metel L.
  • Scopolamine Hydrobromide Powder
  • (aS)-a-(Hydroxymethyl)benzeneacetic Acid (1a,2,4,5a,7)-9-(Methyl-d3)-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl Ester
  • Scopolammonium-d3 Bromide
  • Scopolamine hydrobromide，Hyoscine hydrobromide
  • Scopolaminehydrobromidetrihydra
  • (αS)-α-(hydroxymethyl)-benzeneacetic acid-(1α,2β,4β,5α,7β)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl ester
  • (?)-Scopolamine hydrobromide hydrate
  • (1S,2R)-9-Methyl-3-oxa-9- azatricyclo[3.3.1.02,4]nonan-7-yl (2S)-3-hydroxy-2-phenylpropanoate trihydrate hydrobromide
  • (1S,2R)-9-Methyl-3-oxa-9- azatricyclo[3.3.1.0^{2,4}]nonan-7-yl- (2S)-3-hydroxy-2-phenylpropano
  • .alpha.-(hydroxymethyl)-,9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-ylester,hydrobromide,[7(Benzeneaceticacid
  • 02,4]non-7-ylester,hydrobromide,[7(s)-(1alpha,2beta,4beta,5alpha,7beta)
  • hyoscyinehydrobromide
  • hysco
  • isoscopil
  • kwells
  • l-hyoscinehydrobromide
  • scopamin
  • scopolaminebromide
  • scopolaminiumbromide
  • scopolammoniumbromide
  • scopos
  • sereen
  • triptone
  • ATROSCINE HYDROBROMIDE
  • (A,S)-ALPHA-(HYDROXYMETHYL)BENZENEACETIC ACID (1A,2B,4B,5A,7B)-9-METHYL-3-OXA-9-AZATRICYCLO[3.3.1.02,4]NON-7-YL ESTER HYDROBROMIDE
  • HYOSCINE HBR
  • HYOSCINE HYDROBROMIDE
  • HYOSCINE
  • SCOPOLAMINE HCL
  • Benzeneacetic acid, .alpha.-(hydroxymethyl)-, (1.alpha.,2.beta.,4.beta.,5.alpha.,7.beta.)-9-methyl-3-oxa-9-azatricyclo3.3.1.02,4non-7-yl ester, hydrobromide, (.alpha.S)-
  • HYOSCINEHYDROBROMIDE(ANHYDROUS)
  • SCOPOLAMINE HBR(RG)
  • SCOPOLETIN(AHP)
  • SCOPOLETIN(SH)
  • 1aH,5aH-Tropan-3a-ol, 6b,7b-epoxy-, (-)-tropate (ester), hydrobromide (8CI)
  • Benzeneacetic acid, a-(hydroxymethyl)-, (1a,2b,4b,5a,7b)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl ester, hydrobromide, (aS)- (9CI)
  • Benzeneacetic acid, a-(hydroxymethyl)-, 9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl ester, hydrobromide, [7(S)-(1a,2b,4b,5a,7b)]-