Scopolamine hydrobromide

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Scopolamine hydrobromide

Product Name: Scopolamine hydrobromide
CAS No.: 114-49-8
Chemical Name: Scopolamine hydrobromide
Synonyms: HYOSCINE;HYOSCINE HYDROBROMIDE;triptone;ScopolaMine HBr Trihydrate;hysco;Hyosol;kwells;scopos;sereen;scopamin
CBNumber: CB9363236
Molecular Formula: C17H21NO4.BrH
Formula Weight: 384.26
MOL File: 114-49-8.mol

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Scopolamine hydrobromide Property

Melting point:: 195-199 °C (dry matter)(lit.)
alpha: D25 -24 to -26° (c = 5, calculated on anhydrous basis)
storage temp.: Store at RT
solubility: H₂O: 50 mg/mL
form: powder
color: white to off-white
InChI: InChI=1/C17H21NO4.BrH/c1-18-13-7-11(8-14(18)16-15(13)22-16)21-17(20)12(9-19)10-5-3-2-4-6-10;/h2-6,11-16,19H,7-9H2,1H3;1H/t11-,12-,13-,14+,15-,16+;/s3
InChIKey: WTGQALLALWYDJH-MLRWSLNSNA-N
SMILES: [C@]12([H])O[C@@]1([H])[C@@]1([H])N(C)[C@]2([H])C[C@@H](OC(=O)[C@H](CO)C2C=CC=CC=2)C1.Br |&1:0,3,5,9,12,16,r|
CAS DataBase Reference: 114-49-8(CAS DataBase Reference)
EPA Substance Registry System: Scopolamine hydrobromide (114-49-8)

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Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 36
RIDADR: UN 1544 6.1/PG 1
WGK Germany: 3
RTECS: YM4550000
F: 3-8
HS Code: 2939800000
Toxicity: LD50 in rats (mg/kg): 3800 s.c. (Stockhaus, Wick)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 5.05818
Product name: Scopolamine Hydrobromide - CAS 114-49-8 - Calbiochem
Packaging: 1G
Price: $126
Updated: 2024/03/01

Cayman Chemical

Product number: 14108
Product name: Scopolamine (hydrobromide)
Purity: ≥95%
Packaging: 1mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 14108
Product name: Scopolamine (hydrobromide)
Purity: ≥95%
Packaging: 5mg
Price: $355
Updated: 2024/03/01

Tocris

Product number: 1414
Product name: Scopolamine Hydrobromide
Purity: ≥99%(HPLC)
Packaging: 1G
Price: $87
Updated: 2021/12/16

ApexBio Technology

Product number: N2570
Product name: Scopolamine Hydrobromide
Packaging: 100mg
Price: $42
Updated: 2021/12/16

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Scopolamine hydrobromide Chemical Properties,Usage,Production

Description

Scopolamine is a tropane alkaloid that can be found in many plants of the Solanaceae (nightshade) family. It is a muscarinic receptor antagonist that can be used to induce memory impairment in animals. Scopolamine prevents motion sickness, nausea, and vomiting in animals.

Chemical Properties

Off-White Solid

Uses

An acetylcholine antagonist. Used in treatment of motion sickness; antiemetic; antispasmodic; mydriatic; preanesthetic medicant

Definition

ChEBI: A hydrobromide that is obtained by reaction of scopolamine with hydrogen bromide.

brand name

Isopto Hyoscine (Alcon); Transderm-Scop (Ciba-Geigy).

General Description

Scopolamine hydrobromide(hyoscine hydrobromide) occurs as white orcolorless crystals or as a white, granular powder. It is odorlessand tends to effloresce in dry air. It is freely soluble inwater (1:1.5), soluble in alcohol (1:20), only slightly solublein chloroform, and insoluble in ether.
Scopolamine is a competitive blocking agent of theparasympathetic nervous system as is atropine, but it differsmarkedly from atropine in its action on the higher nervecenters. Both drugs readily cross the blood-brain barrierand, even at therapeutic doses, cause confusion, particularlyin the elderly.

General Description

Colorless crystals or white powder or solid. Has no odor. pH (of 5% solution): 4-5.5. Slightly efflorescent in dry air. Bitter, acrid taste.

Air & Water Reactions

Sensitive to air, light and moisture. Water soluble.

Reactivity Profile

Scopolamine hydrobromide is incompatible with acids, bases and oxidizing agents. .

Fire Hazard

Flash point data for Scopolamine hydrobromide are not available; however, Scopolamine hydrobromide is probably combustible.

Biological Activity

Non-selective muscarinic antagonist. Widely used clinically to treat motion sickness.

Clinical Use

A sufficiently large dose of scopolamine will cause an individualto sink into a restful, dreamless sleep for about8 hours, followed by a period of approximately the samelength in which the patient is in a semiconscious state.During this time, the patient does not remember events thattake place. When scopolamine is administered with morphine,this temporary amnesia is termed twilight sleep.

Metabolism

Hyoscine hydrobromide is almost entirely metabolised, probably in the liver; only a small proportion of an oral dose is excreted unchanged in the urine. In one study in man, 3.4% of a single dose, administered by subcutaneous injection was excreted unchanged in urine within 72 hours.

storage

Store at RT

Purification Methods

The hydrobromide is recrystallised from Me2CO, H2O or EtOH/Et2O and dried. It is soluble in H2O (60%) and EtOH (5%) but insoluble in Et2O and slightly in CHCl3. The hydrochloride has m 300o (from Me2CO). The free base is a viscous liquid which forms a crystalline hydrate with m 59o and [] D 20 -28o (c 2.7, H2O). It hydrolyses in dilute acid or base. [Meinwald J Chem Soc 712 1953, Fodor Tetrahedron 1 86 1957, Beilstein 6 III 4185.]

Scopolamine hydrobromide Preparation Products And Raw materials

Raw materials

Nisin COREOPSISYELLOWEXTRACT

Preparation Products

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View Lastest Price from Scopolamine hydrobromide manufacturers

Changsha Staherb Natural Ingredients Co., Ltd.

Product: Scopolamine hydrobromide; Flos?daturae extract 114-49-8
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99% HPLC
Supply Ability: 1000KG
Release date: 2022-09-21

Guangzhou Tengyue Chemical Co., Ltd.

Product: Scopolamine hydrobromide 114-49-8
Price: US $250.00/grams
Min. Order: 10grams
Purity: 99% Purity (What/sapp: +86 18145728414)
Supply Ability: 1000 Tons/Month
Release date: 2023-06-17

Guangzhou Tengyue Chemical Co., Ltd.

Product: Scopolamine hydrobromide 114-49-8
Price: US $230.00/g
Min. Order: 10g
Purity: 99% purity,WhatsApp+86 18102676775
Supply Ability: 20 tons
Release date: 2023-06-27

114-49-8, Scopolamine hydrobromideRelated Search:

SCOPOLAMINE N-OXIDE HYDROBROMIDE Scopolamine Hydrobromide Trihydrate Scopolamine Pyridine hydrobromide Scopolamine butylbromide (-)-SCOPOLAMINE HYOSCINE HYDROCHLORIDE Scopine DL-(SCOPOLAMINE HYDROBROMIDE) Cimetropium bromide DEXTROMETHORPHAN HYDROBROMIDE HYOSCINE N BUTYL BROMIDE BP Methscopolamine bromide Tropic acid Scopoletin Hydrogen bromide DL-TROPIC ACID SCOPOLAMINE-D3 HBR 3H2O (N-METHYL-D3) Hyoscine Hydrobromide

Benzeneacetic acid, a-(hydroxyMethyl)-, (1a,2b,4b,5a,7b)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-ylester, hydrobroMide (1:1), (aS)-

ScopolaMine HBr Trihydrate

ScopolaMine-d3 HBr 3H2O

Hyosol

Tranaxine

Benzeneacetic acid, α-(hydroxymethyl)-, (1α,2β,4β,5α,7β)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl ester, hydrobromide (1:1), (αS)-

Hyoscine HydrobroMide Trihydrate, (1α,2β,4β,5α,7β)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl Ester HydrobroMide Trihydrate

SCOPOLAMINE HBR

(-)-SCOPOLAMINE HYDROBROMIDE

SCOPOLAMINE HYDROBROMIDE

SCOPOLOAMINE HYDROBROMIDE

SCOPINE TROPATE HYDROBROMIDE

(α,S)-α-(Hydroxymethyl)benzeneaceticacid(1α,2β,4β,5α,7β)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-ylesterhydrobromide

()-Scopolamine hydrobromide trihydrate,Hyoscine hydrobromide, Scopine tropate

(-)-scopolaminebromide

),hydrobromide

scopolamine hydrobromide (anhydrous)

Benzeneacetic acid, a-(hydroxymethyl)-, (1a,2b,4b,5a,7b)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl ester, hydrobromide, (aS)-

(alpha,S)-alpha-(Hydroxymethyl)benzeneacetic acid (1alpha,2beta,4beta,5alpha,7beta)-9-methyl-3-oxa-9-azatricyclo[3.3.1.0(2.4)]non-7-yl ester hydrobromide

(2S,3S,4S,5S)-2,5-bis(hydroxymethyl)pyrrolidine-3,4-diol

Scopolamine hydrobromide, 98%, from Datura metel L.

Scopolamine Hydrobromide Powder

(aS)-a-(Hydroxymethyl)benzeneacetic Acid (1a,2,4,5a,7)-9-(Methyl-d3)-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl Ester

Scopolammonium-d3 Bromide

Scopolamine hydrobromide，Hyoscine hydrobromide

Scopolaminehydrobromidetrihydra

(αS)-α-(hydroxymethyl)-benzeneacetic acid-(1α,2β,4β,5α,7β)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl ester

(?)-Scopolamine hydrobromide hydrate

(1S,2R)-9-Methyl-3-oxa-9- azatricyclo[3.3.1.02,4]nonan-7-yl (2S)-3-hydroxy-2-phenylpropanoate trihydrate hydrobromide

(1S,2R)-9-Methyl-3-oxa-9- azatricyclo[3.3.1.0^{2,4}]nonan-7-yl- (2S)-3-hydroxy-2-phenylpropano

.alpha.-(hydroxymethyl)-,9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-ylester,hydrobromide,[7(Benzeneaceticacid

02,4]non-7-ylester,hydrobromide,[7(s)-(1alpha,2beta,4beta,5alpha,7beta)

hyoscyinehydrobromide

hysco

isoscopil

kwells

l-hyoscinehydrobromide

scopamin

scopolaminebromide

scopolaminiumbromide

scopolammoniumbromide

scopos

sereen

triptone

ATROSCINE HYDROBROMIDE

(A,S)-ALPHA-(HYDROXYMETHYL)BENZENEACETIC ACID (1A,2B,4B,5A,7B)-9-METHYL-3-OXA-9-AZATRICYCLO[3.3.1.02,4]NON-7-YL ESTER HYDROBROMIDE

HYOSCINE HBR

HYOSCINE HYDROBROMIDE

HYOSCINE

SCOPOLAMINE HCL

Benzeneacetic acid, .alpha.-(hydroxymethyl)-, (1.alpha.,2.beta.,4.beta.,5.alpha.,7.beta.)-9-methyl-3-oxa-9-azatricyclo3.3.1.02,4non-7-yl ester, hydrobromide, (.alpha.S)-

HYOSCINEHYDROBROMIDE(ANHYDROUS)

SCOPOLAMINE HBR(RG)

SCOPOLETIN(AHP)

SCOPOLETIN(SH)

1aH,5aH-Tropan-3a-ol, 6b,7b-epoxy-, (-)-tropate (ester), hydrobromide (8CI)

Benzeneacetic acid, a-(hydroxymethyl)-, (1a,2b,4b,5a,7b)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl ester, hydrobromide, (aS)- (9CI)

Benzeneacetic acid, a-(hydroxymethyl)-, 9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl ester, hydrobromide, [7(S)-(1a,2b,4b,5a,7b)]-