alpha-Bromo-p-toluenesulphonyl chloride

Product Name: alpha-Bromo-p-toluenesulphonyl chloride
CAS No.: 66176-39-4
Chemical Name: alpha-Bromo-p-toluenesulphonyl chloride
Synonyms: BUTTPARK 94\04-08;4-Bromomethylbenzenesulfonyl c;4-(Chlorosulphonyl)benzyl bromide;α-bromo-p-toluenesulfonyl chloride;à-bromo-p-toluenesulfonyl chloride;alpha-Bromo-p-toluenesulfonylchloride;ALPHA-BROMO-P-TOLUENESULPHONYL CHLORIDE;4-(BROMOMETHYL)BENZENESULFONYL CHLORIDE;4-bromo methy benzene sulfonyl chloride;4-(BROMOMETHYL)BENZENESULPHONYL CHLORIDE
CBNumber: CB9364844
Molecular Formula: C7H6BrClO2S
Formula Weight: 269.54
MOL File: 66176-39-4.mol

More

Less

alpha-Bromo-p-toluenesulphonyl chloride Property

Melting point:: 71-75 °C(lit.)
Boiling point:: 160-170 °C
Density: 1.6944 (estimate)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: Crystalline Powder
color: Off-white to light yellow
Sensitive: Moisture Sensitive
BRN: 2364328
CAS DataBase Reference: 66176-39-4(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: C
Risk Statements: 34
Safety Statements: 26-36/37/39-45
RIDADR: UN 3261 8/PG 2
WGK Germany: 3
Hazard Note: Corrosive
HazardClass: 8
PackingGroup: II
HS Code: 29049090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 557153
Product name: 4-(Bromomethyl)benzenesulfonyl chloride
Purity: 95%
Packaging: 5g
Price: $110
Updated: 2025/07/31

Sigma-Aldrich

Product number: 557153
Product name: 4-(Bromomethyl)benzenesulfonyl chloride
Purity: 95%
Packaging: 1g
Price: $34.8
Updated: 2023/06/20

TCI Chemical

Product number: B3936
Product name: 4-(Bromomethyl)benzenesulfonyl Chloride
Purity: >95.0%(GC)(T)
Packaging: 1g
Price: $51
Updated: 2025/07/31

TCI Chemical

Product number: B3936
Product name: 4-(Bromomethyl)benzenesulfonyl Chloride
Purity: >95.0%(GC)(T)
Packaging: 5g
Price: $153
Updated: 2025/07/31

TRC

Product number: B688250
Product name: α-Bromo-p-toluenesulfonylChloride
Packaging: 100g
Price: $1265
Updated: 2021/12/16

More

Less

alpha-Bromo-p-toluenesulphonyl chloride Chemical Properties,Usage,Production

Chemical Properties

off-white to light yellow crystalline powder

Uses

4-(Bromomethyl)benzenesulfonyl chloride may be used to synthesize:

4-bromomethyl-N-(6-methoxy-quinolin-8-yl)-benzenesulfonamide
benzene-sulfonamide derivatives, which are potent Chemokine Receptor Type 4 (CXCR4) inhibitors
imidazole derivatives having antifungal activity

Synthesis

98-59-9

66176-39-4

General procedure for the synthesis of 4-bromomethylbenzenesulfonyl chloride from p-toluenesulfonyl chloride: to a stirred solution of p-toluenesulfonyl chloride (20 g, 104.9 mmol) in carbon tetrachloride (500 mL) was added sequentially N-bromosuccinimide (20.6 g, 115.7 mmol) and benzoyl peroxide (2.54 g, 10.84 mmol) at room temperature. The reaction mixture was refluxed for 10 hours and then filtered through a diatomaceous earth pad. The filtrate was concentrated under reduced pressure to give a yellow oil. The oily substance was recrystallized using hexane as eluent to give 4-bromomethylbenzenesulfonyl chloride (20.6 g, 65% yield) as a final white solid.

References

[1] Bulletin of the Korean Chemical Society, 2013, vol. 34, # 5, p. 1487 - 1493
[2] Advanced Synthesis and Catalysis, 2018, vol. 360, # 21, p. 4197 - 4204
[3] Journal of the American Chemical Society, 1957, vol. 79, p. 4232
[4] Journal of Medicinal Chemistry, 1990, vol. 33, # 9, p. 2437 - 2451
[5] Patent: US5318980, 1994, A

alpha-Bromo-p-toluenesulphonyl chloride Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

alpha-Bromo-p-toluenesulphonyl chloride Suppliers

Americas 1 Belgium 1 China 132 Europe 2 France 1 Germany 2 India 6 Japan 2 Switzerland 2 United Kingdom 14 United States 24 Global 187

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

Aceschem Inc.

Tel: +1-817863-6948 +1-（817）863-6948
Email: sales@aceschem.com
Country: United States
ProdList: 19632
Advantage: 58

Alfa Chemistry

Tel: --
Fax: --
Email: info@Alfa-Chemistry.com
Country: United States
ProdList: 6814
Advantage: 0

Frontier Scientific Services, Inc.

Tel: --
Fax: --
Email: customerservice@frontierssi.com
Country: United States
ProdList: 1575
Advantage: 0

Chiral Management

Tel: --
Fax: --
Email: sales@chiralmanagement.com
Country: United States
ProdList: 1332
Advantage: 30

BroadPharm. Inc.

Tel: --
Fax: --
Email: sales@broadpharm.com
Country: United States
ProdList: 891
Advantage: 50

Combi-Blocks Inc.

Tel: --
Fax: --
Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

SynQuest Laboratories, Inc.

Tel: --
Fax: --
Email: info@synquestlabs.com
Country: United States
ProdList: 6871
Advantage: 62

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

TCI America

Tel: --
Fax: --
Email: sales@tciamerica.com
Country: United States
ProdList: 6909
Advantage: 75

Frontier Scientific, Inc.

Tel: --
Fax: --
Email: sales@frontiersci.com
Country: United States
ProdList: 6222
Advantage: 86

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

Anvia Chemicals, LLC

Tel: --
Fax: --
Email: sales@anviachem.com
Country: United States
ProdList: 3933
Advantage: 0

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6962
Advantage: 56

Waterstone Technology, LLC

Tel: --
Fax: --
Email: sales@waterstonetech.com
Country: United States
ProdList: 6786
Advantage: 30

Ryan Scientific, Inc.

Tel: --
Fax: --
Email: ryan.reichlyn@ryansci.com
Country: United States
ProdList: 6439
Advantage: 60

Oakwood Products, Inc.

Tel: --
Fax: --
Email: sales@oakwoodchemical.com
Country: United States
ProdList: 6193
Advantage: 74

Alfa Aesar

Tel: --
Fax: --
Email: tech@alfa.com
Country: United States
ProdList: 6814
Advantage: 81

2A PharmaChem USA

Tel: --
Fax: --
Email: sales@2apharmachem.com
Country: United States
ProdList: 6137
Advantage: 39

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

APAC Pharmaceutical, LLC

Tel: --
Fax: --
Email: sales@apacpharma.com
Country: United States
ProdList: 6322
Advantage: 38

ASDI Incorporated

Tel: --
Fax: --
Email: customerservice@asdi.net
Country: United States
ProdList: 6922
Advantage: 67

Biogene Organics Inc.

Tel: --
Fax: --
Email: sales@biogeneorganics.com
Country: United States
ProdList: 1119
Advantage: 39

More

Less

View Lastest Price from alpha-Bromo-p-toluenesulphonyl chloride manufacturers

Henan Fengda Chemical Co., Ltd

Product: alpha-Bromo-p-toluenesulphonyl chloride 66176-39-4
Price: US $100.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-25

Career Henan Chemical Co

Product: alpha-Bromo-p-toluenesulphonyl chloride 66176-39-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95-99%
Supply Ability: 100kg/week
Release date: 2019-08-05

66176-39-4, alpha-Bromo-p-toluenesulphonyl chlorideRelated Search:

Benzenesulfonyl chloride Mesitylene-2-sulfonyl chloride alpha-Bromo-p-toluenesulphonyl chloride alpha-Toluenesulfonyl chloride

BUTTPARK 94\04-08

ALPHA-BROMO-P-TOLUENESULPHONYL CHLORIDE

4-(BROMOMETHYL)BENZENE-1-SULFONYL CHLORIDE

4-(BROMOMETHYL)BENZENESULFONYL CHLORIDE

4-(BROMOMETHYL)BENZENESULPHONYL CHLORIDE

4-(BROMOMETHYLENE)BENZENESULFONYL CHLORIDE

à-bromo-p-toluenesulfonyl chloride

α-bromo-p-toluenesulfonyl chloride

4-(Bromomethyl)benzenesulphonyl chloride 98%

alpha-Bromo-p-toluenesulfonylchloride

4-(BROMOMETHYL)BENZENESULFONYL CHLORIDE 95%

4-Bromomethylbenzenesulfonyl chloride,95%

4-(Chlorosulphonyl)benzyl bromide

4-(Bromomethyl)benzenesulfonyl Chloride &gt

Benzenesulfonyl chloride, 4-(bromomethyl)-

alpha-Bromo-p-toluenesulphonyl chloride ISO 9001：2015 REACH

4-bromo methy benzene sulfonyl chloride

4-Bromomethylbenzenesulfonyl c

66176-39-4

BrCH2C6H4SO2Cl

C7H6O2BrClS

C7H6BrCIO2S

SULFONYL CHLORIDE

Building Blocks

Organic Building Blocks

Sulfonyl Halides

Sulfur Compounds

Benzenesulfonyl chloride