1-METHYL-1-CYCLOHEXANECARBOXYLIC ACID Property

Melting point:

36-39 °C(lit.)

Boiling point:

234 °C(lit.)

Density 

1.0037 (rough estimate)

refractive index 

1.4600 (estimate)

Flash point:

213 °F

storage temp. 

Sealed in dry,Room Temperature

solubility 

Soluble in chloroform and methanol.

pka

pK1:5.13 (25°C)

form 

Solid

color 

Brown

BRN 

1859220

CAS DataBase Reference

1123-25-7(CAS DataBase Reference)

Safety

Hazard Codes 

Xi

Safety Statements 

24/25

WGK Germany 

3

RTECS 

GU8585500

Hazard Note 

Irritant

HS Code 

29162000

Toxicity

mouse,LD50,intraperitoneal,860mg/kg (860mg/kg),BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)BEHAVIORAL: ATAXIA,Neuropharmacology. Vol. 24, Pg. 427, 1985.

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

1-METHYL-1-CYCLOHEXANECARBOXYLIC ACID Chemical Properties,Usage,Production

Chemical Properties

WHITE TO YELLOW CRYSTALS OR CRYSTALLINE POWDER

Uses

1-Methyl-1-cyclohexanecarboxylic acid was used as internal standard during the determination of valproic acid metabolites. Also been used as an anticonvulsant drug and causes maturation of murine neuroblastoma cells in vitro. Used in the synthesis of p38 map kinase.

Synthesis Reference(s)

The Journal of Organic Chemistry, 38, p. 3633, 1973 DOI: 10.1021/jo00960a047

General Description

1-Methyl-1-cyclohexanecarboxylic acid is the structural analog of valproic acid and its pharmacokinetic action has been studied in female Sprague-Dawley rats.

Biochem/physiol Actions

1-Methyl-1-cyclohexanecarboxylic acid is an anticonvulsant drug and causes maturation of murine neuroblastoma cells in vitro.