18alpha-Glycyrrhetinic acid
Chemical Properties Uses- Product Name
- 18alpha-Glycyrrhetinic acid
- CAS No.
- 1449-05-4
- Chemical Name
- 18alpha-Glycyrrhetinic acid
- Synonyms
- Nsc 35350;Triterpene;Ccris 3963;Brn 2956366;Einecs 215-907-9;18α-Glycyrrhetinic;Enoxolone impurity A;18a-Glycyrrhetic acid;18α-Glycyrrhetic acid;18A-GLYCYRRHETINIC ACID
- CBNumber
- CB7172205
- Molecular Formula
- C30H46O4
- Formula Weight
- 470.68
- MOL File
- 1449-05-4.mol
18alpha-Glycyrrhetinic acid Property
- Melting point:
- 331-333°C
- Boiling point:
- 492.11°C (rough estimate)
- Density
- 0.9967 (rough estimate)
- refractive index
- 1.4800 (estimate)
- storage temp.
- 2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 4.71±0.70(Predicted)
- color
- White to Off-White
- LogP
- 6.570 (est)
- CAS DataBase Reference
- 1449-05-4(CAS DataBase Reference)
N-Bromosuccinimide Price
- Product number
- G8503
- Product name
- 18α-Glycyrrhetinic acid
- Purity
- ≥95%
- Packaging
- 250mg
- Price
- $118
- Updated
- 2025/07/31
- Product number
- G8503
- Product name
- 18α-Glycyrrhetinic acid
- Purity
- ≥95%
- Packaging
- 1g
- Price
- $437
- Updated
- 2025/07/31
- Product number
- 412321
- Product name
- 18α-Glycyrrhetinic Acid
- Packaging
- 100mg
- Price
- $460
- Updated
- 2021/12/16
- Product number
- G735005
- Product name
- 18α-Glycyrrhetinic acid
- Packaging
- 500mg
- Price
- $660
- Updated
- 2021/12/16
- Product number
- CHM0017607
- Product name
- 18ALPHA-GLYCYRRHETINIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $973.84
- Updated
- 2021/12/16
18alpha-Glycyrrhetinic acid Chemical Properties,Usage,Production
Chemical Properties
Glycyrrhetinic acid is a kind of glycoside composed of glycyrrhizic acid-ff two molecules glucuronic acid. It appears as white crystalline powder with sweet taste. The sweetness is about 200 times of the sucrose. Its sweetness is different from other sweeteners such as sucrose. After eating, you can sense the sweetness only after a few moments but the retention time is long. Combination of a small amount of glycyrrhizin and sucrose can save 20% sucrose without affecting the sweetness. Although having no aroma, it has incense effect. It has a melting point (decomposition) of 220 ° C. The aqueous solution is weakly acidic and can be treated by acid.
Uses
Sweeteners; sweetness improving agents; flavor enhancers (dairy products, cocoa products, egg products, mutton), flavoring agents (function well especially when used in combination with salt), Chinese folk mostly use it in sauce and sauce products, pickled goods and so on.
Uses
18α-Glycyrrhetinic acid may be used to synthesize:
- 3-keto-18α-glycyrrhetinic acid
- methyl esters of 18α-glycyrrhetinic acid
- methyl esters of 3-keto-18α-glycyrrhetinic acid
General Description
18α-Glycyrrhetinic acid (18α-GA) is a bioactive triterpenoid found in licorice. It shows selective inhibition of 11-HSD1 (11-hydroxysteroid dehydrogenase 1). It also shows anti-proliferative and apoptotic effect on hepatic stellate cells (HSCs).
in vivo
18α-Glycyrrhetinic acid (18α-GA) treatment significantly enhances life span of C. elegans strains with the most effective concentration being 20?μg/mL. Results reveal a significant delay of paralysis upon 18α-Glycyrrhetinic acid treatment. 18α-Glycyrrhetinic acid treatment also confers a significant reduction of Aβ deposits[2].
IC 50
Proteasome; NF-κB
18alpha-Glycyrrhetinic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 18alpha-Glycyrrhetinic acid manufacturers
- Product
- Glycyrrhetinic acid 1449-05-4 1449-05-4
- Price
- US $7.50/mg
- Min. Order
- 20mg
- Purity
- ≥98%
- Supply Ability
- 1000.00 kgs
- Release date
- 2019-07-11
- Product
- 18alpha-Glycyrrhetinic acid 1449-05-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 18alpha-Glycyrrhetinic acid 1449-05-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-08