ChemicalBook > CAS DataBase List > 4-BROMO-2-METHYL-1-NITROBENZENE

4-BROMO-2-METHYL-1-NITROBENZENE

Product Name
4-BROMO-2-METHYL-1-NITROBENZENE
CAS No.
52414-98-9
Chemical Name
4-BROMO-2-METHYL-1-NITROBENZENE
Synonyms
3-Bromo-6-nitrotoluene;5-Bromo-2-nitrotoluene 98%;2-Methyl-4-bromonitrobenzene;4-BroMo-2-Methylnitrobenzene;4-Bromo-6-methylnitrobenzene;5-Bromo-1-methyl-2-nitrobenzene;4-BROMO-2-METHYL-1-NITROBENZENE;Benzene,4-broMo-2-Methyl-1-nitro-;2-(3-bromo-2-nitrophenyl)acetonitrile;4-Bromo-2-methyl-1-nitrobenzene, 4-Bromo-2-methylnitrobenzene
CBNumber
CB9370708
Molecular Formula
C7H6BrNO2
Formula Weight
216.03
MOL File
52414-98-9.mol
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4-BROMO-2-METHYL-1-NITROBENZENE Property

Melting point:
53-55℃
Boiling point:
265℃
Density 
1.615
refractive index 
1.6120 (estimate)
Flash point:
114℃
storage temp. 
Sealed in dry,Room Temperature
Appearance
White to light yellow Solid
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Safety

HS Code 
2929900090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
B698095
Product name
5-Bromo-2-nitrotoluene
Packaging
100mg
Price
$45
Updated
2021/12/16
TRC
Product number
B698095
Product name
5-Bromo-2-nitrotoluene
Packaging
500mg
Price
$65
Updated
2021/12/16
TRC
Product number
B698095
Product name
5-Bromo-2-nitrotoluene
Packaging
1g
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB55222
Product name
4-Bromo-2-methyl-1-nitrobenzene
Packaging
2g
Price
$120
Updated
2021/12/16
AK Scientific
Product number
W6725
Product name
4-Bromo-2-methyl-1-nitrobenzene
Packaging
5g
Price
$122
Updated
2021/12/16
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4-BROMO-2-METHYL-1-NITROBENZENE Chemical Properties,Usage,Production

Uses

5-Bromo-2-nitrotoluene is used the synthesis of biphenylamide derivatives as Hsp90 C-terminal inhibitor for the treatment of cancer and neurodegenerative diseases.

Synthesis

583-75-5

52414-98-9

General procedure for the synthesis of 4-bromo-2-methyl-1-nitrobenzene from 2-methyl-4-bromoaniline: Step 1: Synthesis of 4-bromo-2-methyl-1-nitrobenzene (193) H2O2 (3.95 mL, 64±5 mmol) was dissolved in DCM (320 mL) at 0°C, cooled and TFAA (10.93 mL, 77 mmol) was added and the mixture was stirred for 5 min at this temperature. The ice bath was then removed, a reflux condenser was installed, and a solution of 4-bromo-2-methylaniline (3 g, 16.12 mmol) in DCM (6.4 mL) was added slowly and dropwise over about 30 minutes. The reaction mixture was heated to reflux for 1 h. After cooling, the reaction mixture was washed sequentially with 30 mL of water and 30 mL of saturated NaHCO3 solution, and the organic layer was dried with MgSO4 and concentrated in vacuum. The crude product was purified by flash column chromatography to give 193 (2.57 g, 11.9 mmol, 74% yield). 1H NMR (CDCl3) δ (ppm): 7.88 (d, J = 8.6 Hz, 1H), 7.53 (d, J = 2.2 Hz, 1H), 7.49 (dd, J = 8.6, 2.2 Hz, 1H), 2.60 (s, 3H).

References

[1] Patent: WO2008/104077, 2008, A1. Location in patent: Page/Page column 122
[2] Journal of Organic Chemistry, 1955, vol. 20, p. 1458
[3] Patent: US4287201, 1981, A

4-BROMO-2-METHYL-1-NITROBENZENE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-BROMO-2-METHYL-1-NITROBENZENE Suppliers

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View Lastest Price from 4-BROMO-2-METHYL-1-NITROBENZENE manufacturers

Henan Fengda Chemical Co., Ltd
Product
4-BROMO-2-METHYL-1-NITROBENZENE 52414-98-9
Price
US $80.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-27
Career Henan Chemical Co
Product
4-BROMO-2-METHYL-1-NITROBENZENE 52414-98-9
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-08

52414-98-9, 4-BROMO-2-METHYL-1-NITROBENZENERelated Search:

2-NITRO 5-BROMO-BENZALDEHYDE 4-BROMO-2-METHYL-1-NITROBENZENE 5-BROMO-2-NITRO-BENZOIC ACID 5-Bromo-2-nitrobenzotrifluoride 1-Bromo-2-methyl-5-nitrobenzene,2-BROMO-1-METHYL-4-NITROBENZENE,3-Bromo-4-methyl-1-nitrobenzene 2,6-DIBROMO-4-NITROTOLUENE 1-Bromo-4-methyl-2-nitrobenzene 2-BROMO-5-NITROTOLUENE 3-BROMO-2-NITROTOLUENE 5-BROMO-3-METHYL-1-NITROBENZENE,1-Bromo-3-methyl-5-nitrobenzene 98%,3-BROMO-5-NITROTOLUENE (5-BROMO-3-METHYL-1-NITROBENZENE),1-BROMO-3-METHYL-5-NITROBENZENE 4-Bromo-2-nitrotoluene 1-BROMO-2-METHYL-3-NITROBENZENE 1-Bromo-2-methyl-6-nitrobenzene 3,5-DIBROMO-2-NITRO-BENZOIC ACID 5-BROMO-2,4-DINITROTOLUENE 3,5-DIBROMO-2,6-DINITROBENZOIC ACID 1-bromo-2,5-dimethyl-4-nitrobenzene 5-Bromo-2-nitrophenylacetic acid

  • 4-BROMO-2-METHYL-1-NITROBENZENE
  • 3-Bromo-6-nitrotoluene
  • 4-Bromo-6-methylnitrobenzene
  • 5-Bromo-1-methyl-2-nitrobenzene
  • 4-Bromo-2-methyl-1-nitrobenzene, 4-Bromo-2-methylnitrobenzene
  • 4-BroMo-2-Methylnitrobenzene
  • Benzene,4-broMo-2-Methyl-1-nitro-
  • 5-Bromo-2-nitrotoluene 98%
  • 2-Methyl-4-bromonitrobenzene
  • 2-(3-bromo-2-nitrophenyl)acetonitrile
  • 52414-98-9