Eprazinone dihydrochloride Property

Melting point:

201° (Toffel-Nadolny, Gielsdorf); mp 160° (Mauvernay)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Methanol (Slightly), Water (Slightly)

form 

Solid

color 

White to Off-White

Safety

Toxicity

LD50 in mice (mg/kg): 729 orally, 38 i.v. (Vacher)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Eprazinone dihydrochloride Chemical Properties,Usage,Production

Originator

Mucitux,Riom,France,1969

Uses

Eprazinone Dihydrochloride is a drug used to improve pulmonary function in patients with chronic bronchitis.

Definition

ChEBI: A hydrochloride obtained by combining eprazinone with two molar equivalents of hydrochloric acid.

Manufacturing Process

61.4 g of 0.2M of 1-(2-phenyl-2-ethoxy)piperazine dihydrochloride, 33.5 g (0.25M) propiophenone, 75 g (0.25M) trioxymethylene, 120 ml of ethanol and 0.4 ml of concentrated HCl are heated under reflux for 4 to 5 hours. The product is allowed to crystallize, then filtered and washed with alcohol. It is dried and recrystallized from methanol containing 10% H2O.
There is thus obtained 60 g of a white crystalline powder soluble in water. Yield: 66%. Melting point: 160°C.

Therapeutic Function

Antitussive