ChemicalBook > CAS DataBase List > 2'-Deoxyadenosine monohydrate

2'-Deoxyadenosine monohydrate

Product Name
2'-Deoxyadenosine monohydrate
CAS No.
16373-93-6
Chemical Name
2'-Deoxyadenosine monohydrate
Synonyms
2-DEOXYADENOSINE MONOHYDRATE;2′-Da;Adenyldeoxy;2'-Deoxyadenosine mo;ADENINE DEOXYRIBOSIDE;2'-DEOXYADENOSINE:H2O;DEOXYADENOSINE HYDRATE;2'-Deoxy-adenosine ,98%;2-DEOXYADENOSINE H2O D2;2-deoxyadenosine 99-100%
CBNumber
CB9375521
Molecular Formula
C10H15N5O4
Formula Weight
269.26
MOL File
16373-93-6.mol
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2'-Deoxyadenosine monohydrate Property

Melting point:
187-189 °C
refractive index 
-25.5 ° (C=0.5, H2O)
storage temp. 
2-8°C
solubility 
H2O: soluble50mg/mL, clear, colorless
form 
powder
color 
White to light beige
Water Solubility 
0.3 g/100 mL (20 ºC)
BRN 
5191174
Stability:
Stable, but air sensitive. Incompatible with strong oxidizing agents.
InChIKey
WZJWHIMNXWKNTO-VWZUFWLJSA-N
CAS DataBase Reference
16373-93-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38-20/21/22
Safety Statements 
24/25-37/39-36-26
RIDADR 
UN2811 6.1/PG 3
WGK Germany 
3
RTECS 
AU7358600
F 
10-23
TSCA 
Yes
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P403Store in a well-ventilated place.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D7400
Product name
2′-Deoxyadenosine monohydrate
Purity
≥99%
Packaging
1g
Price
$73.4
Updated
2024/03/01
Sigma-Aldrich
Product number
D7400
Product name
2′-Deoxyadenosine monohydrate
Purity
≥99%
Packaging
5g
Price
$225
Updated
2024/03/01
TCI Chemical
Product number
D0046
Product name
2'-Deoxyadenosine Monohydrate
Purity
>99.0%(T)
Packaging
5g
Price
$58
Updated
2024/03/01
TCI Chemical
Product number
D0046
Product name
2'-Deoxyadenosine Monohydrate
Purity
>99.0%(T)
Packaging
25g
Price
$229
Updated
2024/03/01
Alfa Aesar
Product number
A11166
Product name
2'-Deoxyadenosine monohydrate, 99%
Packaging
1g
Price
$39
Updated
2024/03/01
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2'-Deoxyadenosine monohydrate Chemical Properties,Usage,Production

Description

2'-Deoxyadenosine monohydrate is an adenosine nucleotide, which can be synthesized by the enzyme adenosine kinase. 2'-Deoxyadenosine monohydrate is a competitive inhibitor of phosphodiesterase, which breaks down cyclic nucleotides to their corresponding monophosphate form. This leads to elevated levels of cAMP, which can cause neuronal death by apoptosis.

Chemical Properties

White crystalline powder

Uses

2'-Deoxyadenosineise is used by some cells as an energy source under energy stress conditions and to affect cAMP levels. 2'-dAdo is used in comparison studies of the functions of adenosine analogues on various biological processes.

Uses

2′-Deoxyadenosine monohydrate has been used:

  • as a component for nucleoside supplementation
  • as a standard for to estimate DNA global methylation rate in proliferating oil palm embryogenic suspensions
  • to reverse sterile alpha motif (SAM) and histidine-aspartate (HD) domain-containing protein (SAMHD1)
  • inhibition of human immunodeficiency virus (HIV-1) and hepatitis B virus (HBV)

Uses

2'-Deoxyadenosine monohydrate is used in the synthesis of 5'-modified 2'-deoxyadenosine analogues as anti-hepatitis C virus agents.

Biochem/physiol Actions

Excess 2′-deoxyadenosine gets converted to adenosine triphosphate (dATP), which inhibits ribonucleotide reductase.

Purification Methods

Purify it by recrystallisation from H2O (hydrated crystals; solubility of the monohydrate is 1.1% in H2O at 20o). It has max 258nm (pH 1), 260nm (pH 7) and 261nm (pH 13). [Ness & Fletcher J Am Chem Soc 81 4752 1959, Walker & Butler Can J Chem 34 1168 1956.] The 3',5'-O-diacetyl derivative has m 151-152o (from EtOAc/pet ether). [Beilstein 26 III/IV 3589.]

2'-Deoxyadenosine monohydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2'-Deoxyadenosine monohydrate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
2'-Deoxyadenosine monohydrate 16373-93-6
Price
US $0.00/kg
Min. Order
1kg
Purity
99%min
Supply Ability
1000kg
Release date
2023-01-13
Hebei Weibang Biotechnology Co., Ltd
Product
2'-Deoxyadenosine monohydrate 16373-93-6
Price
US $10.00/KG
Min. Order
100KG
Purity
99%
Supply Ability
100 mt
Release date
2021-09-27
Henan Bao Enluo International TradeCo.，LTD
Product
2'-Deoxyadenosine monohydrate 16373-93-6
Price
US $80.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000tons
Release date
2023-08-11

16373-93-6, 2'-Deoxyadenosine monohydrateRelated Search:

ADENOSINE 5'-TRIPHOSPHATASE ERBIUM (III) 2,4-PENTANEDIONATE MELIBIOSE 2'-Deoxyadenosine 2'-Deoxyadenosine 5'-phosphate Cyclic AMP 8-BROMOADENOSINE 3'-ADENYLIC ACID 2-Chloroadenosine Vidarabine Adenosine 5'-monophosphate monohydrate N6-Benzoyl-2'-deoxyadenosine Bucladesine sodium N6-ISOPENTENYLADENOSINE-D6 N6-BENZYLADENOSINE ADENOSINE-2':3'-CYCLIC MONOPHOSPHATE, SODIUM SALT 5'-Tosyladenosine N6,N6-DIMETHYLADENOSINE

  • DEOXYADENOSINE HYDRATE
  • ADENINE DEOXYRIBOSIDE
  • ADENINE DEOXYRIBOSIDE HYDRATE
  • ADENINE DEOXYRIBOSIDE MONOHYDRATE
  • 9-(2-DEOXY-BETA-D-RIBOFURANOSYL)ADENINE
  • 9-(2-DEOXY-BETA-D-RIBOFURANOSYL)ADENINE MONOHYDRATE
  • 2'-DEOXYADENOSINE HYDRATE
  • 2'-DEOXYADENOSINE MONOHYDRATE
  • 2-DEOXYADENOSINE MONOHYDRATE
  • 9-(2-Deoxy-β-D-ribofuranosyl)adenine
  • 2-deoxyadenosine 99-100%
  • 2-deoxyadenosine cell culture tested
  • Adenine deoxyriboside~9-(2-Deoxy-beta-D-ribofuranosyl)adenine
  • 9-(2-deoxy-á-d-ribofuranosyl)adenine
  • Deoxyadenosine monohydrate.
  • 2''-DEOXYADENOSINE CELL CULTURE REAGENT WHITE CRYSTALLINE POWDER 98-100%
  • 2''-DEOXYADENOSINE WHITE CRYSTALLINE POWDER 98-100%
  • 2''-DEOXYYADENOSINE MONOHYDRATE
  • 2-DEOXYADENOSINE extrapure
  • 9-(2-Deoxy-β-D-ribofuranosyl)adenine, Adenine deoxyriboside
  • Adenine-2'-deoxyriboside
  • 2'-Deoxyadenosine Monohydrate(2'-dA ? H?O)
  • 2′-Deoxyadenosine,Adeninedeoxyriboside,9-β-D-2′-Deoxyribofuranosidoadenine
  • 2'-Deoxyadenosine monohydrate, ≥99.0%(HPLC)
  • 2'-Deoxyadenosine hydrate,99%
  • 2'-Deoxy-β-D-adenosine Monohydrate
  • 2'-Deoxyadenosine mo
  • 2'-Deoxy-adenosine ,98%
  • 2'-DEOXYADENOSINE:H2O
  • 2′-Da
  • 9-(2-Deoxy-β-D-erythro-pentofuranosyl)-9H-purin-6-aMine Hydrate
  • 9-(2-Deoxy-β-D-erythro-pentofuranosyl)adenine
  • Adenine Deoxyribonucleoside Hydrate
  • Adenine Deoxyribose Hydrate
  • Adenyldeoxy
  • (2R,3S,5R)-5-(6-aMino-9H-purin-9-yl)-2-(hydroxyMethyl)tetrahydrofuran-3-ol hydrate
  • [8-2H]2'-deoxyadenosine Monohydrate
  • Adenosine, 2'-deoxy-,hydrate (1:1)
  • Deoxyadenosine Monohydrat
  • 2'-Deoxyadenosine 1-hydrate
  • 2'-Deoxyadenosine Monohydrate&gt
  • 2'-Deoxyadenosine monohydrate USP/EP/BP
  • 2-DEOXYADENOSINE H2O D2
  • 2''-Deoxy-β-D-adenosine Monohydrate
  • <font color="#ff0000">16373-93-6</font>
  • 2'-Deoxyadenosine Monohydrate, ≥ 99.0%
  • 2'-Deoxyadenosine monohydrate(2'-dA.H2O)
  • 2'-Deoxyadenosine monohydrate
  • 2'-Deoxyadenosine hydrate
  • 16373-93-6
  • 47810-77-9
  • C10H13N5O3xH2O
  • C10H13N5O3H2O
  • AMINE
  • Nucleoside Analogs
  • Nucleosides, Nucleotides, Oligonucleotides
  • Nucleosides
  • Biochemicals and Reagents