Cyclopentyl methyl ether Property

Melting point:

-140°C

Boiling point:

106°C

Density 

0.86

vapor pressure 

59.9 hPa (25 °C)

Flash point:

-1°C(lit.)

refractive index 

1.4210

storage temp. 

Store below +30°C.

solubility 

Chloroform (Sparingly), Methanol (Slightly)

form 

Liquid

color 

APHA: ≤10

explosive limit

1.10-9.90%

Water Solubility 

Miscible with water, alcohols, ketones and hydrocarbons.

Stability:

Volatile

LogP

1.6 at 20℃

EPA Substance Registry System

Cyclopentane, methoxy- (5614-37-9)

Safety

Hazard Codes 

F,Xn

Risk Statements 

11-22-36/38

Safety Statements 

26

RIDADR 

UN3271

WGK Germany 

3

Autoignition Temperature

180 °C

TSCA 

Yes

HS Code 

2909 20 00

HazardClass 

3

PackingGroup 

II

Toxicity

LD50 orally in Rabbit: 200 - 2000 mg/kg LD50 dermal Rat > 2000 mg/kg

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Cyclopentyl methyl ether Chemical Properties,Usage,Production

Overview

Cyclopentyl methyl ether (CPME), also known as methoxycyclopentane, is new environmentally friendly hydrophobic ether solvent with high performance, and could replace tetrahydrofuran, methyl tetrahydrofuran, methyl tert-butyl ether and dioxane and other ether solvents. As a reaction solvent, it can be used for reaction such as Grignard reaction, coupling reaction, coupling amination reaction, metal reduction reaction, Lewis acid reaction and Fried-Clark reaction, etc. It is also used for extraction, crystallization, surface treatment and polymerization processes.

Chemical Properties

Clear liquid

Uses

Cyclopentyl methyl ether is a hydrophobic ether solvent widely used in Grignard reaction, Friedel-Crafts reaction, Claisen condensation and Beckmann reaction. It plays an important role in extraction and polymerization reactions as well as in surface coatings. It is considered as a replacement for tetrahydrofuran, methyl tert-butyl ether, dioxane and other existing ether solvents due to its excellent properties like high boiling point and relative stability under acidic and basic conditions.

Uses

Greener alternative solvent in reactions containing the following reagents:

• Alkali agents
• Lewis acid-mediated reactions
• Organometallic
• Reduction and Oxidation
• Transition metal catalysts
• Azeotropic water removal

Uses

Cyclopentyl methyl ether (CPME) is an alternative to ether solvents such as THF, diethyl ether, and MTBE with a higher resistance to peroxide formation. The more environmentally conservative CPME solvent replaces hazardous solvents in order to achieve sustainability and reduce environmental and operational costs. CPME offers considerable potential and advantage as a direct replacement for CH2Cl2 in binary eluents using MeOH as the modifier with MeOH-DMC and i-PrOH-EtOAc.

General Description

Cyclopentyl methyl ether (CPME) is a greener alternative to other ethereal solvents such as tetrahydrofuran (THF), 2-methyl tetrahydrofuran (2-MeTHF), dioxane (carcinogenic), tert-Butyl methyl ether (MTBE), and 1,2-dimethoxyethane (DME) and thus has been enhanced for "Safer Solvents and Auxiliaries".

Flammability and Explosibility

Highly flammable