ChemicalBook > CAS DataBase List > 3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE

3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE

Product Name
3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE
CAS No.
306936-57-2
Chemical Name
3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE
Synonyms
AKOS B000254;AKOS PAO-0297;ART-CHEM-BB B000254;CHEMBRDG-BB 4301174;3-(4-FLUOROPHENYL)PYRAZOLE-4-CARBOXALDEHYDE;3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE;3-(4-fluorophenyl)-2H-pyrazole-4-carbaldehyde;3-(p-Fluorophenyl)-1H-pyrazole-4-carbaldehyde;3-(4-fluoropropyl) -1H-pyrazol-4-formaldehyde;Pyrazole-4-carboxaldehyde, 3-(4-fluorophenyl)-
CBNumber
CB9396160
Molecular Formula
C10H7FN2O
Formula Weight
190.17
MOL File
306936-57-2.mol
More
Less

3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE Property

Melting point:
160 °C
Boiling point:
416.0±35.0 °C(Predicted)
Density 
1.337±0.06 g/cm3(Predicted)
storage temp. 
2-8°C, stored under nitrogen
form 
powder to crystal
pka
10.69±0.50(Predicted)
color 
White to Orange to Green
Sensitive 
Air Sensitive
CAS DataBase Reference
306936-57-2(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29331990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
683272
Product name
3-(4-Fluorophenyl)-1H-pyrazole-4-carboxaldehyde
Purity
97%
Packaging
1g
Price
$85
Updated
2023/06/20
TCI Chemical
Product number
F1118
Product name
3-(4-Fluorophenyl)pyrazole-4-carboxaldehyde
Purity
>98.0%(GC)
Packaging
1g
Price
$108
Updated
2025/07/31
TCI Chemical
Product number
F1118
Product name
3-(4-Fluorophenyl)pyrazole-4-carboxaldehyde
Purity
>98.0%(GC)
Packaging
5g
Price
$328
Updated
2025/07/31
American Custom Chemicals Corporation
Product number
HCH0020397
Product name
3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE
Purity
95.00%
Packaging
5G
Price
$1233.77
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0020397
Product name
3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE
Purity
95.00%
Packaging
1G
Price
$771.89
Updated
2021/12/16
More
Less

3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE Chemical Properties,Usage,Production

Chemical Properties

White to yellow-orange solid

Synthesis

326-33-0

68-12-2

306936-57-2

General procedure for the synthesis of 3-(4-fluoropropyl)-1H-pyrazole-4-carbaldehyde from 2-(1-(4-fluorophenyl)ethylidene)hydrazine-1-carboxamide and N,N-dimethylformamide: Phosphorochloride (2.1 mL, 23 mmol) was slowly added dropwise to N,N-dimethylformamide (4.4 mL, 57 mmol) at 0 °C. The reaction mixture was stirred at 0 °C for 30 min, then brought to room temperature and continued stirring for 30 min. Subsequently, the reaction mixture was cooled in an ice/water bath and 2-(1-(4-fluorophenyl)ethylidene)hydrazine-1-carboxamide (1.96 g, 10 mmol) was slowly added, controlling the temperature not to exceed 50 °C. After the addition was completed, the reaction system was heated to 80 °C and stirred at this temperature for 2 hours. After completion of the reaction, the mixture was poured into ice (15 g) and the pH was adjusted to 10 with 5N NaOH solution and stirred for 2 hours. Subsequently, the reaction solution was acidified with concentrated hydrochloric acid and stirring was continued for 4 hours. The precipitated solid was collected by filtration, washed with a small amount of water and dried under high vacuum to give the target product 3-(4-fluoropropyl)-1H-pyrazole-4-carbaldehyde (1.5 g, 79% yield).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 18, p. 4932 - 4935
[2] Russian Journal of General Chemistry, 2005, vol. 75, # 5, p. 782 - 789
[3] Patent: WO2013/22766, 2013, A1. Location in patent: Page/Page column 87
[4] European Journal of Medicinal Chemistry, 2017, vol. 133, p. 36 - 49
[5] Journal of Fluorine Chemistry, 2016, vol. 183, p. 59 - 68

3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE Preparation Products And Raw materials

Raw materials

Sodium acetate Ethanol N,N-Dimethylformamide Phosphorus oxitrichloride 4-Fluoroacetophenone Semicarbazide hydrochloride

Preparation Products

More
Less

3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE Suppliers

Americas 1 Belgium 1 China 66 Europe 1 Germany 4 India 6 Japan 1 Russia 2 Switzerland 1 The Netherlands 1 Ukraine 2 United Kingdom 6 United States 17 Global 109
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Nanjing Habo Medical Technology Co., Ltd.
Tel
025-85760892 13376080562
Fax
025-85766769
Email
sales@habotech.com
Country
China
ProdList
884
Advantage
60
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22514
Advantage
55
GIHI CHEMICALS CO.,LTD
Tel
0086-571-86217390
Fax
0086-571-86217391
Email
Sales@gihichem.com
Country
China
ProdList
860
Advantage
58
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
13350
Advantage
58
Shanghai Xingui Biotechnology Co., Ltd.
Tel
15121041756
Email
xingui2022@126.com
Country
China
ProdList
9986
Advantage
58
Shanghai Song Yuan Chemical Technology Co., Ltd.
Tel
010-1234567 18521000990
Fax
86-021-33275113
Email
sonyuanchemical@163.com
Country
China
ProdList
6479
Advantage
50
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
Jiaxing Rich Biological Technology Co., Ltd.
Tel
0573-11111111-1111 18969316891
Fax
-
Email
richmol@163.com
Country
China
ProdList
449
Advantage
50
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Changzhou Hopschain Chemical Co.,Ltd.
Tel
0519-85528066 13775048983
Fax
0519-85528066
Email
sales@hopschem.com
Country
China
ProdList
31553
Advantage
55
Shandong Xiya Chemical Co., Ltd.
Tel
4009903999 13395398332
Fax
0539-6365991
Email
sales@xiyashiji.com
Country
China
ProdList
20794
Advantage
60
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Yantai ShengKailun Chemical Technology Co., Ltd.
Tel
13356901049
Fax
QQ：1025383091
Email
3119594100@qq.com
Country
China
ProdList
7964
Advantage
55
Amatek Scientific Co. Ltd.
Tel
0512-56316828
Fax
0512-56316826
Email
info@amateksci.com
Country
China
ProdList
28785
Advantage
58
Shandong Ono Chemical Co., Ltd.
Tel
0539-6362799 20）
Fax
0539-6362799（To 20）
Country
China
ProdList
10007
Advantage
58
Aikon International Limited
Tel
025-66113011 13155353615
Fax
(7)02557626880
Email
qzhang@aikonchem.com
Country
China
ProdList
15394
Advantage
58
Rhawn Reagent
Tel
400-400-1332688 18019345275
Fax
400-133-2688
Email
amy@rhawn.cn
Country
China
ProdList
14948
Advantage
58
Yujinpharma(Tianjin) Technology Co.,Ltd.
Tel
13370351217 kungfu1217@1
Fax
QQ1400885609
Email
kungfu1217@163.com
Country
China
ProdList
2720
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57422
Advantage
58
TCI Chemicals
Tel
021-67121386, 800-988-0390
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
5391
Advantage
58
Xinyi Kaiwu Chemical Technology Co., Ltd.
Tel
0516-0516-88997009 18651776937
Email
4164357@qq.com
Country
China
ProdList
3204
Advantage
58
Allfluoro pharmaceutical co. ltd.
Tel
+86-400-0216110 +86-15958047586
Fax
0086-21-33275002
Email
sales@allfluoro.com
Country
China
ProdList
11385
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
+86-0551-65418684 +8618949823763
Fax
0086-551-65418684
Email
sales@tnjchem.com
Country
China
ProdList
25356
Advantage
58
Shanxi Xuanran Import and Export Trade Co., Ltd.
Tel
+8617735180244
Email
mike_yan@xuanranglobal.com
Country
CHINA
ProdList
4017
Advantage
58
Zhejiang Lianshuo Biotechnology Co., Ltd.
Tel
18616526224
Email
lianshuo@vip.126.com
Country
China
ProdList
9607
Advantage
58
Guangdong Wengjiang Chemical Reagent Co., Ltd.
Tel
0751-2886766 13927870850
Fax
0751-2886756
Email
3001267247@qq.com
Country
China
ProdList
9941
Advantage
58
Chongqing Chemdad Co., Ltd
Tel
+86-023-6139-8061 +86-86-13650506873
Email
sales@chemdad.com
Country
China
ProdList
39927
Advantage
58
CONIER CHEM AND PHARMA LIMITED
Tel
+8618523575427
Email
sales@conier.com
Country
China
ProdList
49975
Advantage
58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd
Tel
+8613580539051
Email
joe@yuhengpharm.com
Country
CHINA
ProdList
21142
Advantage
58
Changzhou Kechem Bio-Scientific Co., LTD.
Tel
0519-68985668 13685222090
Fax
qq735434464
Email
sales@kechem.cn
Country
China
ProdList
26028
Advantage
58
CHG Opto-Electronic Corporation Limited
Tel
2537653158 16621191650
Fax
QQ 2537653158
Email
2537653158@qq.com
Country
China
ProdList
7299
Advantage
58
Zhengzhou Convergence Chemical Co. LTD
Tel
0371-0371-53736046 13393710386
Fax
QQ:2853979814
Email
2853979814@qq.com
Country
China
ProdList
9948
Advantage
58
Yantai Boyun Biological Technology Co. Ltd
Tel
13793517650; 13793517650
Email
2767277144@qq.com
Country
China
ProdList
2856
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 4008210725
Email
malulu@leyan.com
Country
China
ProdList
40000
Advantage
58
Bide Pharmatech Ltd.
Tel
400-6005915
Email
sales@picasso-e.com
Country
China
ProdList
39665
Advantage
58
Jiaxing Zhejia Biotechnology Co., LTD
Tel
0573-85609002 18367600069;
Email
zhejia01@163.com
Country
China
ProdList
8887
Advantage
58
Shaanxi Dideu Newmaterial Co., Ltd.
Tel
029-029-63373950 17392216152
Email
1050@dideu.com
Country
China
ProdList
9998
Advantage
58
Shanghai Yanbang Pharmaceutical Technology Co., Ltd
Tel
15618536883
Email
1228181347@qq.com
Country
China
ProdList
7951
Advantage
58
Yantai Sheng Kai Lun Biological Products Co. , Ltd.
Tel
13356901049
Email
mark@sklnchem.cn
Country
China
ProdList
7996
Advantage
58
Hangzhou Bingochem Co., Ltd.
Tel
0571-8512-5372
Email
sales@bingochem.com
Country
China
ProdList
21669
Advantage
58
Shanghai Aladdin Biochemical Technology Co.,Ltd.
Tel
400-6206333 13167063860
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
48457
Advantage
58
Shanghai Chemilab Biotechnology CO.,Ltd
Tel
18116465878
Email
kmlb@kaimilaibo.com
Country
China
ProdList
2627
Advantage
58
Merck KGaA
Tel
21-20338288
Email
ordercn@merckgroup.com
Country
China
ProdList
6394
Advantage
58
More
Less

View Lastest Price from 3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE manufacturers

Career Henan Chemical Co
Product
3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE 306936-57-2
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
200KG
Release date
2018-12-23

306936-57-2, 3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDERelated Search:

3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE 1H-Pyrazole-4-carboxaldehyde 3-(4-FLUOROPHENYL)-1-P-TOLYL-1H-PYRAZOLE-4-CARBALDEHYDE RARECHEM AL BF 1274 1-(4-BROMOPHENYL)-3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE 3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID 3-(4-FLUORO-PHENYL)-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID 3-(4-FLUORO-PHENYL)-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE 3-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE 3-[3-(4-FLUOROPHENYL)-4-FORMYL-1H-PYRAZOL-1-YL]PROPANENITRILE 1,3-BIS(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE 1-(3-CHLORO-4-FLUOROPHENYL)-3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE RARECHEM AL BO 2161 5-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE 3-[3-(3,4-DIFLUOROPHENYL)-4-FORMYL-1H-PYRAZOL-1-YL]PROPANENITRILE 1-(4-CHLOROPHENYL)-3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE 1-(3-CHLOROPHENYL)-3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE 1-(2,4-DIFLUOROPHENYL)-3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE

  • AKOS B000254
  • AKOS PAO-0297
  • 3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE
  • 3-(4-FLUOROPHENYL)PYRAZOLE-4-CARBOXALDEHYDE
  • CHEMBRDG-BB 4301174
  • ART-CHEM-BB B000254
  • 3-(4-Fluorophenyl)-1H-pyrazole-4-carboxaldehyde
  • 3-(4-Fluorophenyl)-1H-pyrazole-4-carboxaldehyde 97%
  • 3-(4-Fluorophenyl)-1H-pyrazole-4-carboxaldehyde97%
  • 3-(4-fluorophenyl)-1H-pyrazole-4-carbaldehyde(SALTDATA: FREE)
  • Pyrazole-4-carboxaldehyde, 3-(4-fluorophenyl)-
  • 3-(4-Fluorophenyl)-1H-pyrazole-4-carbaldehyde ,97%
  • 5-(4-Fluorophenyl)-1H-pyrazole-4-carboxaldehyde
  • 3-(4-fluorophenyl)-2H-pyrazole-4-carbaldehyde
  • 3-(4-fluorophenyl)-2H-pyrazole-4-carboxaldehyde
  • JR-8855, 3-(4-Fluorophenyl)pyrazole-4-carboxaldehyde, 97%
  • 3-(p-Fluorophenyl)-1H-pyrazole-4-carbaldehyde
  • 1H-Pyrazole-4-carboxaldehyde, 3-(4-fluorophenyl)-
  • 3-(4-fluoropropyl) -1H-pyrazol-4-formaldehyde
  • 3-(4-FLOURO PHENYLE) -1H-PYRAZOLE -4-CARBOXALDEHYDE
  • 3-(4-Fluorophenyl)-1<i>H</i>-pyrazole-4-carboxaldehyde
  • 306936-57-2
  • New Products for Chemical Synthesis May/June 2007
  • Building Blocks
  • C10
  • C10-C12
  • Carbonyl Compounds
  • Chemical Synthesis
  • Fluorinated Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Heterocyclic Fluorinated Building Blocks
  • Organic Building Blocks
  • Other Fluorinated Heterocycles
  • Aldehydes
  • Pyrazoles & Triazoles
  • Pyrazoles & Triazoles
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Pyrazoles